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Mar 21, 2019

With Launch Of New CRISPR Company, Competition Extends To Diagnostics

Posted by in categories: bioengineering, biotech/medical, space

The gene editing technology CRISPR, which has spawned several startups aiming to use the tool to develop new therapies, is now the inspiration for a new company in a less-crowded space: diagnostic testing.

Sherlock Biosciences is launching in Cambridge, Massachusetts, with $35 million in funding. That includes $17.5 million in the form of a non-dilutive grant from the Open Philanthropy Project, an organization primarily funded by Dustin Moskovitz, the billionaire cofounder of Facebook and Asana, and his spouse, Cari Tuna. The Open Philanthropy Project is also making a separate investment in Sherlock, along with other undisclosed investors. CEO Rahul Dhanda says he’s still raising more funding for the company’s Series A.

One of Sherlock Biosciences’ key technologies comes from the Broad Institute lab of Feng Zhang, who did some of the early work elucidating the DNA-modifying potential of CRISPR and its associated enzymes after their discovery in bacteria.

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Mar 21, 2019

New technique could help regrow tissue lost to periodontal disease

Posted by in categories: biotech/medical, neuroscience

According to the U.S. Centers for Disease Control and Prevention, about half of all Americans will have periodontal disease at some point in their lives. Characterized by inflamed gums and bone loss around teeth, the condition can cause bad breath, toothache, tender gums and, in severe cases, tooth loss. Now, in ACS Nano, researchers report development of a membrane that helps periodontal tissue regenerate when implanted into the gums of rats.

To regrow lost gum tissue and bone, scientists have tried implanting pieces of polymers that form a protected niche near the root of a tooth, recruiting nearby stem cells and helping them differentiate into new gum and bone cells. However, a second surgery is usually required to remove the polymeric , which can get in the way of the healing process. Although researchers have developed biodegradable membranes, these materials don’t tend to work as well for re-growing periodontal tissue. Alireza Moshaverinia, Paul Weiss and colleagues wanted to develop a membrane that would enhance periodontal tissue regeneration and then be absorbed by the body when healing was complete.

The researchers made nanofibrous membranes of poly(ε-caprolactone), a biocompatible polymer already approved for medical applications. They then coated the membrane with polydopamine (PDA), a synthetic polymer that mimics the sticky protein that mussels use to attach to wet surfaces. In the lab, dental-derived stem cells adhered to the membrane and differentiated. The PDA coating also attracted calcium and phosphate ions, leading to early bone mineralization. When the researchers implanted the membranes into the gums of rats with periodontal defects, at the defect sites regenerated to normal levels within eight weeks. By this time, the membranes had degraded and were absorbed by the rats.

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Mar 21, 2019

Sounds and vibrations are quite similar for the brain, finds new study

Posted by in categories: biotech/medical, mobile phones, neuroscience

We all know the feeling of a mobile phone vibrating in our hands when announcing an incoming call. If we perceive these vibrations so clearly, it is due to specialized receptors that transduce them into neural signals sent to our brain. But how does the latter encode their physical characteristics? To understand this, neuroscientists from the University of Geneva (UNIGE) have observed what happens in the brains of mice whose forepaws perceive vibrations. They discovered that neurons in the somatosensory cortex are activated in a manner similar to those in the sound-reactive auditory cortex. These results, published in the journal Nature, suggest that feeling a phone vibrate or hearing it ring is ultimately based on the same brain codes.

If you place a glass of water on your desk, you can probably see on its surface the concentric oscillatory motions created by the small movements that occur nearby. These oscillations are caused by vibrations that propagate through the floor, desk, glass and all other solid surfaces. These vibrations are also important sensory stimuli that we use to detect, for example, an approaching train or to identify the familiar step of our office neighbor. «We live surrounded by vibrations that are extremely important in how we perceive the world,» explains Daniel Huber at the Department of Basic Neurosciences at the UNIGE Faculty of Medicine, who led this work. «So we wanted to know how the brain perceives and represents them.».

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Mar 21, 2019

With single gene insertion, blind mice regain sight

Posted by in category: biotech/medical

People left blind by retinal degeneration have one option: electronic eye implants. Neuroscientists have now developed an alternative: gene therapy that, in tests, restored vision in blind mice. A gene for green opsin delivered via virus gave blind mice enough sight to discern patterns on an iPad at a resolution sufficient for humans to read. Given existing AAV eye therapies already approved, this new therapy could be ready for clinical trials in three years.

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Mar 21, 2019

Beyond Metformin For Aging — Jahahreeh Finley — IdeaXme — Ira Pastor

Posted by in categories: aging, bioengineering, biotech/medical, cryonics, futurism, genetics, health, life extension, neuroscience, science

Mar 21, 2019

Without Humans, A.I. Can Wreak Havoc

Posted by in categories: government, robotics/AI

As the World Wide Web marks its 30th birthday on Tuesday, public discourse is dominated by alarm about Big Tech, data privacy and viral disinformation. Tech executives have been called to testify before Congress, a popular campaign dissuaded Amazon from opening a second headquarters in New York and the United Kingdom is going after social media companies that it calls “digital gangsters.” Implicit in this tech-lash is nostalgia for a more innocent online era.


Let’s not let artificial intelligence put society on autopilot.

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Mar 20, 2019

Protein-slaying drugs could be the next blockbuster therapies

Posted by in categories: biotech/medical, neuroscience

Researchers are hijacking the cell’s protein-disposal system in the fight against Alzheimer’s and intractable cancers.

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Mar 20, 2019

The best topological conductor yet: Spiraling crystal is the key to exotic discovery

Posted by in categories: computing, quantum physics

The realization of so-called topological materials—which exhibit exotic, defect-resistant properties and are expected to have applications in electronics, optics, quantum computing, and other fields—has opened up a new realm in materials discovery.

Several of the hotly studied topological materials to date are known as . Their surfaces are expected to conduct electricity with very little resistance, somewhat akin to superconductors but without the need for incredibly chilly temperatures, while their interiors—the so-called “bulk” of the material—do not conduct current.

Now, a team of researchers working at the Department of Energy’s Lawrence Berkeley National Laboratory (Berkeley Lab) has discovered the strongest topological conductor yet, in the form of thin crystal samples that have a spiral-staircase structure. The team’s study of crystals, dubbed topological chiral crystals, is reported in the March 20 edition of the journal Nature.

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Mar 20, 2019

Japan Poised to Declare CRISPR-Edited Foods Safe to Eat

Posted by in categories: biotech/medical, food

Just so long as people making the food don’t leave any foreign DNA in it.

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Mar 20, 2019

Alexandra Albani added a new photo

Posted by in categories: futurism, space travel

Astronomers found a pulsar hurtling through space at nearly 2.5 million miles an hour — so fast it could travel the distance between Earth and the Moon in just 6 minutes. The discovery was made using NASA’s Fermi Gamma-ray Space Telescope and the National Science Foundation’s Karl G. Jansky Very Large Array (VLA).


“Thanks to its narrow dart-like tail and a fortuitous viewing angle, we can trace this pulsar straight back to its birthplace,” said Frank Schinzel, a scientist at the National Radio Astronomy Observatory (NRAO) in Socorro, New Mexico. “Further study of this object will help us better understand how these explosions are able to ‘kick’ neutron stars to such high speed.” Schinzel, together with his colleagues Matthew Kerr at the U.S. Naval Research Laboratory in Washington, and NRAO scientists Dale Frail, Urvashi Rau and Sanjay Bhatnagar presented the discovery at the High Energy Astrophysics Division meeting of the American Astronomical Society in Monterey, California. A paper describing the team’s results has been submitted for publication in a future edition of The Astrophysical Journal Letters.

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