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Scientists at Sanford Burnham Prebys Medical Discovery Institute have shown that two prebiotics, mucin and inulin, slowed the growth of melanoma in mice by boosting the immune system’s ability to fight cancer. In contrast to probiotics, which are live bacterial strains, prebiotics are “food” for bacteria and stimulate the growth of diverse beneficial populations. The study, published today in Cell Reports, provides further evidence that gut microbes have a role in shaping the immune response to cancer, and supports efforts to target the gut microbiome to enhance the efficacy of cancer therapy.

The research specifically opens new avenues to address important unmet clinical needs in , as it highlights the possible impact of prebiotics on growth control and therapy resistance.

“Earlier studies have demonstrated that prebiotics limit tumor growth, but until now the mechanism by which they do so has been unclear,” says Ze’ev Ronai, Ph.D., professor in Sanford Burnham Prebys’ Tumor Initiation and Maintenance Program and senior author of the study. “Our study shows for the first time that prebiotics limit cancer growth by enhancing anti-tumor immunity. The study supports further exploration of the potential benefits of prebiotics in treating cancer or augmenting current therapies.”

Congratulations to Osinakachi Gabriel for his launch of the first publication the TAFFD’s “Magazine of the Future” — Also thanks for the Bioquark (page 37) and Regenerage (page 72) profiles — https://issuu.com/taffds/docs/taffd_s_magazine_2019 #Futurism #Longevity #Transhumanism #Biotechnology #Health #Wellness #Regeneration #LifeExtension #Aging #Immortality #IraPastor #Bioquark #Regenerage #Ideaxme #Singularity #Consciousness #AI #JasonSilva #ArtificiaIIntelligence #SENS


In this first issue by Trandisciplinary Agora For Future Discussions, we approach reality from a transdisciplinary perspective in order to find unity and greater understanding of the world as we enter a new paradigm in technological advancements that will lead us to transcending our own biology while enhancing our mental and physical limitations. We explore all topics that relate to transhumanism, cybernetic singularity, energy, consciousness, international policy, electromagnetic forces, language, AI, digitalization, ethics, philosophy, biotechnology, futurism and more.

A Yale University experiment, led by neuroscientist Nenad Sestanwhich reawakened the brains of slaughtered pigs has raised speculation that human trials could be next, renewing ethical concerns over the pursuit of immortality. In the experiments, the pigs did not regain consciousness but Sestan acknowledged that restoring awareness is a possibility and that the technique could work on humans, keeping the brain alive indefinitely.

Nottingham Trent University ethics researcher Benjamin Curtis says ending up as a disembodied brain might just be a “living hell.” Writing in The Conversation he suggested that living without any actual contact with reality could be a fate worse than death. “Some have argued that even with a fully functional body, immortality would be tedious. With absolutely no contact with external reality, it might just be a living hell,” Curtis wrote.

Curtis explained that the brain is highly integrated with the rest of the body in both humans and animals. It is constantly receiving and sending signals from and to it. “We have no idea what experiences would occur within a disembodied brain. But those experiences may well be deeply disturbing,” he said.

In a surprising study, Oregon State University researchers found that no matter how much stress they placed on mice from either a high-fat diet or strenuous exercise, the animals’ mitochondria were able to adapt and continue their normal processes.

The findings could have major implications for the study of diseases like diabetes, Parkinson’s and Alzheimer’s, all of which are associated with an impairment in the breaking-down and clearance of damaged mitochondria.

Mitochondria are the structures that house cellular respiration, the process used to turn nutrients into energy. Dysfunction in mitochondria may lead to lower energy production, greater inflammation and tissue damage. Yet as central as mitochondria are to living organisms, scientists still don’t know exactly what keeps them healthy—or makes them unhealthy.

Circa 2004


On the largest scales, matter in the Universe is arranged in a vast network of filamentary structures known as the ‘cosmic web’, its tangled strands spanning hundreds of millions of light years. Dark matter, which emits no light, forms the backbone of this web, which is also suffused with primordial hydrogen gas left over from the Big Bang. Galaxies like our own Milky Way are embedded inside this web, but fill only a tiny fraction of its volume.

Now a team of astronomers led by Khee-Gan Lee, a post-doc at the Max Planck Institute for Astronomy, has managed to create a three-dimensional map of a large region of the far-flung cosmic web nearly 11 billion light years away, when the Universe was just a quarter of its current age. Similar to a medical CT scan, which reconstructs a three-dimensional image of the human body from the X-rays passing through a patient, Lee and his colleagues reconstructed their map from the light of distant background galaxies passing through the cosmic web’s hydrogen gas.

The use of the combined starlight of background galaxies for this purpose had been thought to be impossible with current telescopes – until Lee carried out calculations that suggested otherwise. Lee says: “I was surprised to find that existing large telescopes should already be able to collect sufficient light from these faint galaxies to map the foreground absorption, albeit at a lower resolution than would be feasible with future telescopes. Still, this would provide an unprecedented view of the cosmic web which has never been mapped at such vast distances.”