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By and Targeting Metabesity to examine the links between metabesity, Longevity and the USA’s current health shortfalls, including low health-adjusted life expectancy (“HALE”) and the large gap between HALE and life expectancy, despite its extremely high per-capita healthcare expenditures, and to chart policy recommendations to neutralize this vast health vs wealth deficit.

€œMetabesity and Longevity: USA Special Case Study € is an 85-page open-access analytical report produced jointly by Aging Analytics Agency and Targeting Metabesity to examine the links between metabesity, Longevity and the USA €™s current health shortfalls, including low health-adjusted life expectancy ( €œHALE €) and the large gap between HALE and life expectancy, despite its extremely high per-capita healthcare expenditures, and to chart policy recommendations to neutralize this vast health vs wealth deficit.

Link to Special Case Study: https://aginganalytics.com/longevity-usa/

As the issue of aging population intensifies, sick care will become increasingly expensive and ineffective. America needs to rapidly deploy a government-led shift from treatment to prevention, and from prevention to precision health, using deep diagnostics and prognostics in combination with biomarkers of aging, metabesity, health and intervention-effectiveness, to delay the onset of disease with as minimal intervention as possible, as early as possible. Seeking synergies between Longevity research, P4 (preventive, personalized, precision and participatory) medicine and Artificial Intelligence has the potential to enable rapid and widespread policy and infrastructural reforms for USA healthcare to quickly boost National Healthy Longevity, but only with sufficient government commitment.

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Each year, heart attacks kill almost 10 million people around the world, and more than 6 million die from stroke. A heart attack is caused by clots that block arterial blood flow. Tissues are deprived from blood-borne oxygen. Under these conditions, the affected tissues undergo a rapid necrosis. But why? Scientists at the University of Geneva (UNIGE), Switzerland, the University of Lyon and the Institut National de la Santé et de la Recherche Médicale (Inserm), France, have discovered that the synthesis of a lipid called deoxydihydroceramide provokes necrosis. This lipid accumulates in the absence of oxygen and blocks cellular functions. By inhibiting its synthesis in a mouse suffering a heart attack, the biologists were able to reduce the tissue damage by 30 percent. These results, published in Nature Metabolism, suggest a new model of treatment for victims of heart attack or stroke.

“But what causes necrosis under these conditions?” asked Howard Riezman, professor in the Department of Biochemistry of the Faculty of Science at UNIGE and Director of the NCCR Chemical Biology. Not all animals are so sensitive to the absence of —worms can live three days without oxygen, some turtles can live several months, and certain bacteria indefinitely.

“That is why we sought to find the link between the lack of oxygen and necrosis in mammals,” said the scientist.

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We’re continuing to release talks from Ending Age-Related Diseases 2019, our highly successful two-day conference that featured talks from leading researchers and investors, bringing them together to discuss the future of aging and rejuvenation biotechnology.

Dr. Peter Fedichev, co-founder of GERO, discussed biomarkers in the context of mouse research, particularly physiological frailty and blood cell counts. He introduced a new index, the Dynamic Frailty Index, and explained it in detail, including the advantages that it has over conventional frailty models and epigenetic clocks. He also explained the differences between humans and mice, most notably the fact that interventions that work in mice do not always apply to human beings.

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Brain-machine interface enthusiasts often gush about “closing the loop.” It’s for good reason. On the implant level, it means engineering smarter probes that only activate when they detect faulty electrical signals in brain circuits. Elon Musk’s Neuralink—among other players—are readily pursuing these bi-directional implants that both measure and zap the brain.

But to scientists laboring to restore functionality to paralyzed patients or amputees, “closing the loop” has broader connotations. Building smart mind-controlled robotic limbs isn’t enough; the next frontier is restoring sensation in offline body parts. To truly meld biology with machine, the robotic appendage has to “feel one” with the body.

This month, two studies from Science Robotics describe complementary ways forward. In one, scientists from the University of Utah paired a state-of-the-art robotic arm—the DEKA LUKE—with electrically stimulating remaining nerves above the attachment point. Using artificial zaps to mimic the skin’s natural response patterns to touch, the team dramatically increased the patient’s ability to identify objects. Without much training, he could easily discriminate between the small and large and the soft and hard while blindfolded and wearing headphones.

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New research from North Carolina State University shows that unique materials with distinct properties akin to those of gecko feet—the ability to stick to just about any surface—can be created by harnessing liquid-driven chaos to produce soft polymer microparticles with hierarchical branching on the micro- and nanoscale.

The findings, described in the journal Nature Materials, hold the potential for advances in gels, pastes, foods, nonwovens and coatings, among other formulations.

The soft dendritic particle materials with unique adhesive and structure-building properties can be created from a variety of polymers precipitated from solutions under special conditions, says Orlin Velev, S. Frank and Doris Culberson Distinguished Professor of Chemical and Biomolecular Engineering at NC State and corresponding author of the paper.

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The 17” x 14” X-ray film, gels, and blots are widely used in DNA research. However, DNA laser scanners are costly and unaffordable for the majority of surveyed biotech scientists who need it. The high-tech breakthrough analytical personal scanner (PS) presented in this report is an inexpensive 1 lb hand-held scanner priced at 2–4% of the bulky and costly 30–95 lb conventional laser scanners. This PS scanner is affordable from an operation budget and biotechnologists, who originate most science breakthroughs, can acquire it to enhance their speed, accuracy, and productivity. Compared to conventional laser scanners that are currently available only through hard-to-get capital-equipment budgets, the new PS scanner offers improved spatial resolution of 20 microns, higher speed (scan up to 17” x 14” molecular X-ray film in 48 s), 1–32,768 gray levels (16-bits), student routines, versatility, and, most important, affordability.

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The smallest pieces of nature—individual particles like electrons, for instance—are pretty much interchangeable. An electron is an electron is an electron, regardless of whether it’s stuck in a lab on Earth, bound to an atom in some chalky moon dust or shot out of an extragalactic black hole in a superheated jet. In practice, though, differences in energy, motion or location can make it easy to tell two electrons apart.

One way to test for the similarity of particles like electrons is to bring them together at the same time and place and look for interference—a that arises when particles (which can also behave like waves) meet. This interference is important for everything from fundamental tests of quantum physics to the speedy calculations of quantum computers, but creating it requires exquisite control over particles that are indistinguishable.

With an eye toward easing these requirements, researchers at the Joint Quantum Institute (JQI) and the Joint Center for Quantum Information and Computer Science (QuICS) have stretched out multiple photons—the quantum particles of light—and turned three distinct pulses into overlapping quantum waves. The work, which was published recently in the journal Physical Review Letters, restores the interference between photons and may eventually enable a demonstration of a particular kind of quantum supremacy—a clear speed advantage for computers that run on the rules of quantum physics.

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