Lifeboat Foundation

On the 23rd of this month, Dr. David Sinclair did an Ask Me Anything over at the Futurology subreddit in support of the NAD+ Mouse Project on Lifespan.io. There were a range of interesting questions from the community about his work in aging research, particularly the role of NAD+ in aging.

Dr. David A. Sinclair is a Professor in the Department of Genetics at Harvard Medical School and a co-joint Professor in the Department of Physiology and Pharmacology at the University of New South Wales. He is the co-Director of the Paul F. Glenn Laboratories for the Biological Mechanisms of Aging and a Senior Scholar of the Ellison Medical Foundation. He obtained his Ph.D. in Molecular Genetics at the University of New South Wales, Sydney in 1995. He worked as a postdoctoral researcher at M.I.T. with Dr. Leonard Guarente; there, he co-discovered a cause of aging for yeast as well as the role of Sir2 in epigenetic changes driven by genome instability.

More recently, he has been in the spotlight for his work with NAD+ precursors and their role in aging and has been helping to develop therapies that replace NAD+, which is lost with aging, in order to delay the diseases of old age. Below are a selection of questions and answers from the AMA, and we urge you to head over to Reddit Futurology to check out the other questions that people asked.

The Boring Company is almost ready to show off its first tunnel under LA, designed to be the ultimate hack for commuters.

by

• Eric Mack

How high economic inequality negatively impacts nearly every aspect of human well-being—as well as the health of the biosphere.

In addition, a small number of posters will be selected for oral presentation.

Poster topics should lie within the scope of the conference: Research contributing to the eventual postponement of age-related decline in health, with an emphasis on measures that repair damage rather than slowing its creation. Poster submissions are due on January 31, 2019.

To submit your poster go to:

Continue reading “The 2019 Undoing Aging Conference will again include poster sessions” »

The brilliant Prof Judith Campisi from Buck Institute on Aging on senescence, senolytics, healthspan and more, a new interview.

Anti-aging pioneer Judith Campisi explains how a recent breakthrough could ward off age-related disease.

The future of humanity will be radically different than what we see today. As Ray Kurzweil put it, “We won’t experience 100 years of progress in the 21st century—it will be more like 20,000 years of progress (at today’s rate).” We’ll have the potential to live on Mars, connect our minds to machines, and access an abundance of resources.

But is our youth prepared to live in such a world? Are we equipping them with the skills and values necessary to be adaptable, innovative, and purpose-driven in such a world?

Our traditional, industrial-era educational models are simply outdated. What is required is not an incremental change in education, but rather an entire overhaul of the current system. It will take creative imagination to develop new models for 21st-century education.

After a gyroscope failure put the Hubble Space Telescope out of action on October 5, NASA engineers finally see an end to its troubles. They have its backup gyroscope operating within a normal range and expect science operations to resume imminently.

The space telescope entered a low-power safe mode in early October, suspending science operations while engineers here on Earth diagnosed, then attempted to fix the problem.

At maximum efficiency, Hubble uses three gyroscopes for orienting itself to observe a target in the sky. These gyros measure the speed at which the telescope turns, so that it can be aimed accurately.

Continue reading “NASA Engineers Basically Jiggled The Hubble Telescope to Fix Its Recent Problem” »

Scientists have previously suspected supermassive black holes can merge together, and have seen signs of these cosmic collisions on a smaller scale. Now new research backs up the hypothesis – and shows evidence that it could be happening all across the Universe.

Astronomers studying detailed radio maps of jet sources – powerful beams of ionised matter thrown out by black holes – have found a surprisingly high number of scenarios that matched patterns consistent with binary black holes (two black holes orbiting each other).

Jet stream radio map. (M. Krause/University of Hertfordshire)

Continue reading “We Now Have Evidence That Supermassive Black Holes Could Be Spectacularly Colliding Across The Universe” »