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RNA secondary structure is critical to RNA regulation and function. We report a new N3-kethoxal reagent that allows fast and reversible labeling of single-stranded guanine bases in live cells. This N3-kethoxal-based chemistry allows efficient RNA labeling under mild conditions and transcriptome-wide RNA secondary structure mapping. The authors designed a chemical probe, azido-kethoxal, to specifically label guanosine in single-strand RNAs in live cells that could be used to determine transcriptome-wide RNA secondary structures.

Princess Cruises to host a series of events in 2020 to demonstrate elite global connectivity.

LUXEMBOURG & SANTA CLARITA, Calif. — Princess Cruises, a leading brand of the Carnival Corporation & plc (NYSE/LSE: CCL; NYSE: CUK), has announced a new dimension in its connectivity partnership with SES (PAR/LuxSE: SESG) and will become the first global cruise ship fleet with early access to SES’s ground-breaking O3b mPOWER network augmenting the Princess MedallionClass™ experience as it scales across the fleet.

SES is enabling global, high-performance connectivity to Princess Cruises using its hybrid medium earth orbit (MEO) and geostationary (GEO) network. The combination of the globally-deployed Princess MedallionClass ships, the Ocean Guest Experience “Cloud Connected” Platform and SES’s multi-constellations satellite network not only creates unmatched and ubiquitous global Wi-Fi service levels, but ensures seamless land/sea digital experience enablement including OceanView® TV (OTT, Mobile and VOD) and is disrupting the traditional commodity satellite bandwidth model.

Elon Musk is recruiting for his AI team at Tesla, and he says education is “irrelevant.” The team members will report “directly” to Musk and “meet/email/text” with Musk “almost every day.” Musk will also throw a “super fun” party at his house with the Tesla artificial intelligence and autopilot teams.

Complex cognitive dissonance disorder guaranteed. 😬.


Garrett Lisi, the so called “Surf Bum with a Theory of Everything (or T.O.E.)”, is a PhD theoretical physicist who has refused to be captured by the theoretical physics community. By making shrewd investments, he has avoided holding meaningful employment for his entire adult life. Instead, he lives in Maui and travels the world chasing the perfect wave.

In this episode Garrett and Eric sit down to discuss the current status of Garrett’s ideas for a final theory based on a mysterious object called E8, perhaps the oddest of mathematical symmetries to be found in the universe. Garrett and Eric have held each other in mutual “contempt” for over a decade. By vacationing together and staying in each others’ homes, they had hoped to hone and deepen their mutual disgust for each other’s ideas. However, as the theoretical physics community moved away from actually trying to unify our incompatible models of the physical world, it became intellectually unmoored, and drifted toward a culture of performative Cargo Cult Physics. The antagonists were thus forced by necessity to develop a begrudging admiration for each other’s iconoclasm and unwillingness to give up on the original dream of Einstein to unify and understand our world.

Researchers have created a unique device which will unlock the elusive terahertz wavelengths and make revolutionary new technologies possible.

Terahertz waves (THz) sit between microwaves and infrared in the light frequency spectrum, but due to their low-energy scientists have been unable to harness their potential.

The conundrum is known in scientific circles as the terahertz gap.

Amid mounting concern about a novel coronavirus spreading from China, Lawrence Livermore National Laboratory (LLNL) researchers have developed a preliminary set of predictive 3D protein structures of the virus to aid research efforts to combat the disease.

The models are based on the genomic sequence of the novel coronavirus and a protein found in the virus that causes Severe Acute Respiratory Syndrome (SARS), which closely resembles the new virus.

The researchers plan to use the models to accelerate countermeasure design, using a combination of machine learning, biological experiments and simulation on supercomputers.


As global concern continues to rise about a novel coronavirus spreading from China, a team of Lawrence Livermore National Laboratory (LLNL) researchers has developed a preliminary set of predictive 3D protein structures of the virus to aid research efforts to combat the disease.

Researchers at the University of Toronto Scarborough transformed used cooking oil from deep fryers at McDonald’s into a biodegradable resin.

Turns out that leftover cooking oil in McDonald’s deep fryers is actually good for 3D printing.

Researchers at the University of Toronto Scarborough were able to turn it into a biodegradable resin, they announced in a press release.

Most modern electronic devices rely on tiny, finely-tuned electrical currents to process and store information. These currents dictate how fast our computers run, how regularly our pacemakers tick and how securely our money is stored in the bank.

In a study published in Nature Physics, researchers at the University of British Columbia have demonstrated an entirely new way to precisely control such electrical currents by leveraging the interaction between an electron’s spin (which is the quantum it inherently carries) and its orbital rotation around the nucleus.

“We have found a new way to switch the electrical conduction in materials from on to off,” said lead author Berend Zwartsenberg, a Ph.D. student at UBC’s Stewart Blusson Quantum Matter Institute (SBQMI). “Not only does this exciting result extend our understanding of how electrical conduction works, it will help us further explore known properties such as conductivity, magnetism and superconductivity, and discover new ones that could be important for quantum computing, data storage and energy applications.”

Roboticists at the California Institute of Technology launched an initiative called RoAMS, which uses the latest research in robotic walking to create a new kind of medical exoskeleton. With the ability to move dynamically, using neurocontrol interfaces, these exoskeletons allow users to balance and walk without the crutches. Learn more in the latest IEEE Spectrum article! https://ieeexplore.ieee.org/document/8946313 #RoAMS #exoskeletons


Bipedal robots have long struggled to walk as humans do-balancing on two legs and moving with that almost-but-not-quite falling forward motion that most of us have mastered by the time we’re a year or two old. It’s taken decades of work, but robots are starting to get comfortable with walking, putting them in a position to help people in need.