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Like buoys bobbing on the ocean, many receptors float on the surface of a cell’s membrane with a part sticking above the water and another underwater, inside the cell’s cytoplasm. But for cells to function, these receptors must be docked at specific regions of the cell. Most research has focused on the ‘underwater’ portions. That’s where the cell’s molecular machines swarm and interact with a receptor’s underwater tails, with those interactions then fueling signals that dive deep into the nucleus, changing the cell’s course.

New work by a team of Thomas Jefferson University researchers reveals new activity above the surface, in brain-cell receptors that govern learning and chronic pain. In the study, the authors show that the ‘above water’ portion of proteins can help dock the proteins at synapses, where neurons mediate flow of information throughout the brain. This discovery opens the possibility of using this docking site as a target to develop treatments for chronic pain and other diseases more effectively. The study was published January 29th in Nature Communications.

“The extracellular spaces — the parts ‘above the water’ — have been largely overlooked,” says senior author Matthew Dalva, PhD, professor and vice chair of the Department of Neuroscience and director of the Jefferson Synaptic Biology Center in the Vickie & Jack Institute for Neuroscience — Jefferson Health. Dr. Dalva and his team looked at the NMDAR receptor on brain cells and pinpointed the spot where this receptor interacts with a neighbor to initiate signaling. “When trying to develop new therapy, finding the bullseye is half the problem,” says Dr. Dalva.

Astronomers using the new Daniel K. Inouye Solar Telescope in Hawaii have released their first public images of the Sun, and they are the most detailed images of our parent star ever taken. Images from the next-generation National Science Foundation (NSF) solar observatory reveal details on the surface measuring just 30 kilometers (18 miles) in diameter.

The new four-meter (157 inch) instrument (the largest solar telescope in the world) recorded images and video of turbulent plasma on the surface of the Sun, providing an unprecedented level of detail for solar researchers.

Neuroprosthesis is the process of using direct electric stimulation to enable proper functioning of the nervous system. Neuroprosthetic devices supplements the input or the output signals to the neural system, enabling the individual to carry out proper functioning and physical activities. Some of the purposes which involve the use of neuroprosthetics include, techniques for bladder and bowel control, deep brain stimulation, and restoration of mobility and respiration to paralyzed individuals.

Get PDF sample copy of study @ http://bit.ly/39hTnku

Brain disorders exhibits a considerable social and economic burden in Europe. According to WHO survey, brain disorders are responsible for 35% of Europe’s total disease burden. This burden is increasing due to increasing number of aging population in Europe, and requires a considerable attention to address the treatment issues as all the cases does not respond to medication therapy.

Scientists are scrambling to develop a vaccine against coronavirus 2019-nCoV and plan to use advanced bioprocessing methods and techniques to accelerate production.

#coronavirus #vaccine #bioprocessing


At present there is no vaccine against the coronavirus However, various groups have started working on them, including Johnson & Johnson (J&J).

Sarah Smith, senior manager, communications & public affairs, EMEA at J&J’s Janssen unit, tells GEN that, “We began working on a vaccine two weeks ago, when the viral sequence became publicly available, and are hopeful that we can create a candidate vaccine for this virus and can start a Phase I clinical study within approximately 8–12 months. If necessary, we will work to scale up production of a suitable vaccine candidate in parallel. While it is possible that the virus could disappear relatively fast, we started the work quickly because we want to be prepared.”