A team of US scientists has just solved a long-standing biological mystery – how exactly do millipedes mate? Using a variety of novel imaging methods, including microscopic ultraviolet photography and micro-CT scanning, the research finally figured out how these tiny creatures get it on.
“This is the first time we’ve been able to understand these millipedes’ mechanism of insertion, how the male and female organs interact with each other,” says Petra Sierwald, from Chicago’s Field Museum and one of the study’s authors. “Before this, we had no idea how he would actually get the sperm into her.”
Millipedes can generally be somewhat shy organisms, so getting them to mate in laboratory conditions hasn’t been easy. The new study focused on a type of small, brown North American millipede called Pseudopolydesmus, known for being more than willing to mate, even in the most exhibitionist situations.
Silicon Valley legends. Billionaire financiers. Patent attorneys. They’re all awakening to the massive potential of an industry preparing to emerge from darkness.
As the novel coronavirus outbreak continues to batter China, the country’s central bank has implemented a new strategy to contain the virus — deep cleaning and destroying potentially infected cash.
The new measures, announced by the People’s Bank of China on Saturday, aim to contain the spread of the virus, officially known as Covid-19. There is still a lot unknown about the virus, which has infected more than 71,000 people globally and killed 1,775, the majority in China — but it appears to survive for at least several hours on surfaces, according to the World Health Organization.
This is why buildings in affected areas are regularly disinfecting elevator buttons, door handles, and other commonly-touched surfaces — and why people are worried about cash, which changes hands multiple times a day.
“It’s a 320-square-foot shipping container like you would see on a boat, a train, a truck, outfitted with an automated growing system,” he says, “to grow about 3.5 acres worth of produce with no pesticides, no herbicides, and about 98.5% less water.” Inside the Greenery, plants grow vertically, with their roots in a nutrient solution instead of soil. Sensors, pumps, and LED lights automatically maintain ideal growing conditions, so you don’t have to be an expert to start farming. “You plug it in and you’re growing same day,” McNamara says.
If there is a discernible duty here it is surely to create the best possible child. That is what it is to act for the best, all things considered. This we have moral reasons to do; but they are not necessarily overriding reasons.
Steven Hawking initially predicted that we might have about 7.6 billion years to go before the Earth gives up on us; he recently revised his position in relation to the Earth’s continuing habitability as opposed to its physical survival: “We must also continue to go into space for the future of humanity,” he said recently. “I don’t think we will survive another thousand years without escaping beyond our fragile planet.”
Steven Hawking: “I don’t think we will survive another thousand years without escaping beyond our fragile planet.”
Probably the most notable direct result of space exploration is satellites. Once we could position a ship in orbit and take telemetry, we knew we could place unmanned pieces of equipment there and just let it orbit, running on its own, while receiving orders from the ground. From those satellites, we have created a global communication system and the global positioning system (GPS) that powers most of our communications capabilities today. What can bring peace and harmony on the planet more than our ability to communicate with each other beyond geographic and political boundaries? These technologies have been enhancing and saving for years.
Thanks to orbital technologies, we could explore the surrounding universe through orbital telescopes and the International Space Station (ISS). We have been studying the universe through lenses unhindered by the atmosphere. We’ve sent drones to explore the moon, Mars and other astral bodies in our solar system. Just like in the early space race, our engineers found yet more solutions that will improve our Earthly lives.
In October 2019, Liu and his colleagues published a paper in Nature, describing an even newer technology, called prime editing. Prime editing can not only make all twelve of the possible base substitutions, it can also make multiple-base insertions or deletions, without requiring a double-strand break. It achieves this with a multi-step operation that first cuts one strand, then performs the appropriate substitution, insertion, or deletion, and then nicks the second strand to allow the bases on the second strand to be replaced by bases that complement the ones substituted, inserted into or deleted from the first strand. The result is a modified stretch of DNA that had never been completely separated. This has the effect of massively reducing the number of off-target modifications.
This new prime editing variant of CRISPR technology, can make the same corrections to the defects that cause sickle cell disease and beta-thalassemia that standard CRISPR/Cas9 has now made in human subjects, but with less opportunity for unwanted off-target changes. Furthermore, its possible applicability is much wider. The ClinVar database lists over 75,000 pathogenic mutations in the human genome. Of these, over 89% are potentially correctable by prime editing.
From zinc fingers to TALE, to CRISPR/Cas9 to base editing and now to prime editing, progress in gene editing has been accelerating. The next advances are currently being aggressively pursued in laboratories all over the world. It will probably be several years before the therapies that are currently being researched are applied routinely in a clinical setting. However, for people who up until recently have had no hope for a cure to a disease suffered by their child, or even themselves, these are exciting times. The prospect of effective treatments, or even cures, is now a valid cause for hope.
The Human Genome Project is probably the most ambitious scientific proposal ever made.
ii. writing DNA
Synthesising short, single stranded fragments of DNA, called oligonucleotides (oligos for short) has been automated and affordable for a number of years now, and almost every biology laboratory in the world uses these short fragments (usually 18–25 base-pairs — compare this to the human genome which is 3 billion base-pairs long) for applications ranging from disease diagnostics to making genetically modified plants. What really has been a game-changer in DNA synthesis is the ability to synthesise longer pieces of DNA and the ability to join these together efficiently to form synthetic gene length fragments.
