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Oct 20, 2019

Researchers obtain the first mice born with hyper-long telomeres

Posted by in categories: biotech/medical, genetics, life extension

A chance finding 10 years ago led to the creation by researchers of the Spanish National Cancer Research Centre (CNIO) of the first mice born with much longer telomeres than normal in their species. Telomeres shorten throughout life, so older organisms have shorter telomeres. Given this relationship between telomeres and aging, the scientists launched a study generating mice in which 100 percent of their cells had hyper-long telomeres. The findings are published in Nature Communications and show only positive consequences: The animals with hyper-long telomeres live longer and in better health, free from cancer and obesity. This marks the first time that longevity has been significantly increased without any genetic modification.

“This finding supports the idea that, when it comes to determining longevity, genes are not the only thing to consider,” says Maria Blasco, head of the CNIO Telomeres and Telomerase Group and intellectual author of the paper. “There is margin for extending life without altering the genes.”

Telomeres form the ends of chromosomes in the nucleus of each cell in the body. Their function is to protect the integrity of the genetic information in DNA. Whenever the cells divide the telomeres, they are slightly shortened, so one of the main characteristics of aging is the accumulation of in cells. “Telomere shortening is considered to be one of the primary causes of aging, given that short telomeres cause aging of the organism and reduce longevity,” the authors write in a paper published in Nature Communications.

Oct 20, 2019

Are You Ready for the Future of Transhumanism?

Posted by in categories: biotech/medical, cyborgs, mobile phones, robotics/AI, transhumanism

Are you ready for the future? A Transhumanist future? One where everyone around you—friends, family, and neighbors—has dipped into the transhumanist punch bowl. A future of contact lenses that see in the dark, endoskeleton attached artificial limbs that lift a half-ton, and brain chip implants that read your thoughts and instantly communicate them to others. Sound crazy? Indeed, it does. Nevertheless, it’s coming soon. Very soon. In fact, much of the technology already exists. Some of it’s being sold commercially at your local superstore or being tested in laboratories right now around the world.

We’ve all heard about driverless test cars on the roads and how doctors in France are replacing people’s hearts with permanent robotic ones, but did you know there’s already a multi-billion dollar market for brain wave reading headsets? Using electroencephalography (EEG) sensors that pick up and monitor brain activity, NeuroSky’s MindWave can attach to Google Glass and allow you to take a picture and post it to Facebook and Twitter just by thinking about it. Other headsets allow you to play video games on your iPhone just with your thoughts too. In fact, well over a year ago now, the first mind-to-mind communication took place. A researcher in India projected a thought to a colleague in France, and using their headsets, they understood each other. Telepathy went from science fiction to reality.

The history of transhumanism—the burgeoning field of science and radical tech used to describe robotic implants, prosthetics, and cyborg-like enhancements in the human being and its experience—has come a long way since scientists began throwing around the term a half century ago. What a difference a generation or two makes. Today a thriving pro-cyborg medical industry is setting the stage for trillion-dollar markets that will remake the human experience. Five million people in America suffer from Alzheimer’s, but a new surgery that involves installing brain implants is showing promise in restoring people’s memory and improving lives. The use of medical and microchip implants, whether in the brain or not, are expected to surge in the coming years. Some experts surmise as many as half of Americans will have implants by 2020. I already have one in my hand. It’s truly a new age for humans.

Oct 20, 2019

Help Them See the Future

Posted by in categories: futurism, life extension

Dessie is a hundred years old.

By most standards this is a ripe old age, one most of us would be grateful to be given. Assuming our health remained decent, most of us would be content to live for seventy or eighty years.

Help Them See the Future, a joint venture between Integrated Health Systems and Maximum Life Foundation, created a campaign to give Dessie gene therapies designed to halt or potentially reverse some of the hallmarks of aging. We are sad to announce that, after suffering a stroke shortly after the campaign was launched, Dessie is no longer a suitable candidate for treatment.

Oct 20, 2019

Tennessee researchers join call for responsible development of synthetic biology

Posted by in categories: bioengineering, biotech/medical, food, genetics, policy

Engineering biology is already transforming technology and science, and a consortium of researchers across many disciplines in the international Genome Project-write is calling for more discussion among scientists, policy makers and the general public to shepherd future development. In a policy forum article published in the October 18 issue of Science, the authors outline the technological advances needed to secure the transformative future of synthetic biology and express their concerns that the implementation of the relatively new discipline remains safe and responsible.

Two researchers with the University of Tennessee Institute of Agriculture are co-authors on the piece titled “Technological challenges and milestones for writing genomes: requires improved technologies.” Neal Stewart and Scott Lenaghan with the UTIA departments of Plant Sciences and Food Science, respectively, join Nili Ostrov, a Ph.D. research fellow in genetics at Harvard Medical School, and 18 other leading scientists from a number of institutions and disciplines, in outlining a potential timeline for the development of what they call transformative advances to and society.

Stewart and Lenaghan are the co-directors of the UT Center for Agricultural Synthetic Biology (CASB). Formed in 2018, Stewart says CASB is the first synthetic center in the world aimed specifically at improved agriculture. A professor of plant sciences in the UT Herbert College of Agriculture, Stewart also holds the endowed Racheff Chair of Excellence in Plant Molecular Genetics. Lenaghan is an assistant professor in the Department of Food Science who also holds an adjunct position in the UT Mechanical, Aerospace, and Biomedical Engineering (MABE) Department.

Oct 20, 2019

Hacking Darwin: How the coming genetics revolution will play out

Posted by in categories: biological, genetics

Humanity is poised to take a huge leap forward, as a convergence of next-gen technologies combine to give us unprecedented power over our own biology. Here’s a roadmap to the key technologies and how it’s going to play out in the coming decades.

Oct 19, 2019

Quantum Paradox Experiment May Lead to More Accurate Clocks and Sensors

Posted by in categories: particle physics, quantum physics

More accurate clocks and sensors may result from a recently proposed experiment, linking an Einstein-devised paradox to quantum mechanics. University of Queensland physicist Dr Magdalena Zych said the international collaboration aimed to test Einstein’s twin paradox using quantum particles in a ‘superposition’ state.

Oct 19, 2019

Experience augmented reality like never before with the Microsoft Hololens2

Posted by in category: augmented reality

https://www.microsoft.com/en-us/hololens/hardware ~via Microsoft #churchofperpetuallife #perpetuallife #microsoft See More.

Oct 19, 2019

Army bio-inspired theoretical research may make robots more effective on the future battlefield

Posted by in categories: military, particle physics, robotics/AI

In an effort to make robots more effective and versatile teammates for Soldiers in combat, Army researchers are on a mission to understand the value of the molecular living functionality of muscle, and the fundamental mechanics that would need to be replicated in order to artificially achieve the capabilities arising from the proteins responsible for muscle contraction.

Bionanomotors, like myosins that move along actin networks, are responsible for most methods of motion in all life forms. Thus, the development of artificial nanomotors could be game-changing in the field of robotics research.

Researchers from the U.S. Army Combat Capabilities Development Command’s Army Research Laboratory have been looking to identify a design that would allow the artificial nanomotor to take advantage of Brownian motion, the property of particles to agitatedly move simply because they are warm.

Oct 19, 2019

The universe might be full of Earth-like exoplanets, study suggests

Posted by in categories: chemistry, space

Earth-like exoplanets may be quite common in the universe, a new UCLA study suggests.

Scientists led by Alexandra Doyle, a University of California, Los Angeles (UCLA) graduate student of geochemistry and astrochemistry, came up with a new method to analyze the geochemistry of planets outside our solar system for the study, which was published in the journal Science this week.

“We have just raised the probability that many rocky planets are like the Earth and there’s a very large number of rocky planets in the universe,” co-author Edward Young, UCLA professor of geochemistry and cosmochemistry, said in a statement.

Oct 19, 2019

Downregulation of the inflammatory network in senescent fibroblasts and aging tissues of the long‐lived and cancer‐resistant subterranean wild rodent, Spalax

Posted by in categories: biotech/medical, life extension, neuroscience

The blind mole rat (Spalax) is a wild, long‐lived rodent that has evolved mechanisms to tolerate hypoxia and resist cancer. Previously, we demonstrated high DNA repair capacity and low DNA damage in Spalax fibroblasts following genotoxic stress compared with rats. Since the acquisition of senescence‐associated secretory phenotype (SASP) is a consequence of persistent DNA damage, we investigated whether cellular senescence in Spalax is accompanied by an inflammatory response. Spalax fibroblasts undergo replicative senescence (RS) and etoposide‐induced senescence (EIS), evidenced by an increased activity of senescence‐associated beta‐galactosidase (SA‐β‐Gal), growth arrest, and overexpression of p21, p16, and p53 mRNAs. Yet, unlike mouse and human fibroblasts, RS and EIS Spalax cells showed undetectable or decreased expression of the well‐known SASP factors: interleukin‐6 (IL6), IL8, IL1α, growth‐related oncogene alpha (GROα), SerpinB2, and intercellular adhesion molecule (ICAM‐1). Apparently, due to the efficient DNA repair in Spalax, senescent cells did not accumulate the DNA damage necessary for SASP activation. Conversely, Spalax can maintain DNA integrity during replicative or moderate genotoxic stress and limit pro‐inflammatory secretion. However, exposure to the conditioned medium of breast cancer cells MDA‐MB‐231 resulted in an increase in DNA damage, activation of the nuclear factor κB (NF‐κB) through nuclear translocation, and expression of inflammatory mediators in RS Spalax cells. Evaluation of SASP in aging Spalax brain and intestine confirmed downregulation of inflammatory‐related genes. These findings suggest a natural mechanism for alleviating the inflammatory response during cellular senescence and aging in Spalax, which can prevent age‐related chronic inflammation supporting healthy aging and longevity.