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Insulin, a hormone essential for regulating blood sugar and lipids, is normally produced by pancreatic β cells. In many people with diabetes, however, pancreatic cells are not (or no longer) functional, causing a chronic and potentially fatal insulin deficiency that can only be controlled through daily insulin injections. However, this approach has serious adverse effects, including an increased risk of life-threatening hypoglycaemia, and it does not restore metabolic balance. In order to improve therapy, researchers at the University of Geneva (UNIGE), Switzerland, have identified a protein called S100A9 which, under certain conditions, seems to act as a blood sugar and lipid regulator while avoiding the most harmful side effects of insulin. This discovery, that can be read in Nature Communications, paves the way for better treatment of diabetes and could significantly improve the quality of life for tens of millions of people affected by insulin deficiency.

Today, insulin injections are essential for the survival of patients with type 1 diabetes or a severe form of type 2 diabetes. However, this treatment is not without risk: overdose can trigger hypoglycaemia, i.e. a drop in blood glucose levels that can lead to coma or even death. But underdosed, it can lead to equally dangerous hyperglycaemia. In addition, insulin is involved in the control of ketones, elements that are produced when the liver breaks down lipids in the absence of sufficient glucose reserves, which become toxic in too large quantities. In addition, long-term insulin treatments cause excess fat and cholesterol in the blood and therefore increases the risk of cardiovascular disease.

As early as 2010, Roberto Coppari’s team, a professor at the Diabetes Centre of the UNIGE Faculty of Medicine, highlighted the gluco- and lipid-regulatory properties of leptin, a hormone involved in hunger control. “However, leptin has proved difficult to use pharmacologically in human beings due to the development of leptin resistance,” says Roberto Coppari. “In order to overcome this problem, we shifted our focus on the metabolic mechanisms triggered by leptin rather than on the hormone itself.”

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“Does Aubrey de Grey make SENS?” This is episode 12 of my Pessimistic Guide to Anti-Aging Research. I describe (and judge) some elements of A. de Grey’s numerous activities.

Denis Rebrikov also told Nature that he does not plan to implant gene-edited embryos until he gets regulatory approval.

Maybe interesting.

Few subjects in business and technology are causing as much interest and excitement – or fear and distrust – right now as artificial intelligence. Aalto Leaders’ Insight talked with Teemu Roos, Associate Professor at the Department of Computer Science, University of Helsinki, about a few common myths about AI.

Continue reading “5 + 1 Myths about Artificial Intelligence” »

Scientists believe they may have caught a glimpse of a parallel universe bumping up against ours.

They’ve seen hints in signals from the most distant points of the universe that suggest the fabric of our universe has been disrupted by another incredibly different universe. Their analysis may be the proof for the multiverse theory.

According to researchers: “Dr Ranga-Ram Chary examined the noise and residual signals in the cosmic microwave background left over from the Big Bang (pictured) and found a number of scattered bright spots which he believes may be signals of another universe bumping into our own billions of years ago.”

At least that’s the tentative conclusion researchers have come to. According to some cosmological theories, collisions of alternative universes should be possible. Theories conclude that our universe is like a bubble among many.

Continue reading “Scientists may have discovered parallel universe” »

Help SENS Research Foundation cure age related disease while winning the opportunity of an unforgettable experience. Donate any amount now smile http://www.lifespan.io/MitoMouse

World renowned Harvard professor and anti-aging expert David Sinclair was recently on the Joe Rogan Podcast. For over 2 hours, he discussed some of the keys to maximizing the human lifespan. We’ve condensed his advice into five things you can do right now to battle the aging process with information that is current, researched, and powerful. So if you’ve interested in learning how to maximize your chances to live longer, take a look at the information below.

1. Premium Anti-Aging Nutrition

Although aging is the greatest risk factor for cancer, a recent study demonstrates how aging cells might, paradoxically, hinder cancer progression.

Are we alone in the universe? It comes down to whether intelligence is a probable outcome of natural selection, or an improbable fluke. By definition, probable events occur frequently, improbable events occur rarely—or once. Our evolutionary history shows that many key adaptations—not just intelligence, but complex animals, complex cells, photosynthesis, and life itself—were unique, one-off events, and therefore highly improbable. Our evolution may have been like winning the lottery … only far less likely.

The universe is astonishingly vast. The Milky Way has more than 100 billion stars, and there are over a trillion galaxies in the visible universe, the tiny fraction of the universe we can see. Even if habitable worlds are rare, their sheer number—there are as many planets as stars, maybe more—suggests lots of life is out there. So where is everyone? This is the Fermi paradox. The universe is large, and old, with time and room for intelligence to evolve, but there’s no evidence of it.

Could intelligence simply be unlikely to evolve? Unfortunately, we can’t study extraterrestrial life to answer this question. But we can study some 4.5 billion years of Earth’s history, looking at where evolution repeats itself, or doesn’t.