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Mar 11, 2019

FDA Approves New Fast-Acting Ketamine-Derived Antidepressant Spray

Posted by in categories: biotech/medical, neuroscience

A nasal spray that could alleviate symptoms of depression in just a few hours has been approved by the US Food and Drug Administration (FDA) – though the decision has attracted its share of criticism and controversy. The new drug, called esketamine, is a molecular variation of ketamine, which is already being used as an anesthetic, an antidepressant, and a party drug.

Esketamine will be sold as a spray called Spravato and is intended for patients with treatment-resistant depression, meaning they have failed to respond to at least two other types of antidepressant. Because of ketamine’s mind-altering effects and high potential for abuse, patients will be required to take Esketamine in a doctor’s office or clinic and remain under medical supervision for two hours after administration.

Most people with a diagnosis of depression are prescribed selective serotonin reuptake inhibitors (SSRIs) such as Prozac. These ensure that neurons have access to an increased amount of the neurotransmitter serotonin, which is a key emotional regulator. However, it is thought that around one-third of people with major depressive disorder (MDD) do not respond to conventional medications for the condition, which is why researchers are hunting for alternative treatments.

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Mar 11, 2019

NASA’s #Moon2Mars Update

Posted by in category: space travel

Monday, March 11 at 1 p.m. EDT: NASA Administrator Jim Bridenstine will share the work underway to return astronauts to the Moon and onward to Mars. Watch & explore how we’ll get from the #Moon2Mars:…020-budget

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Mar 11, 2019

Transhumanism, the Lazy Way to Human ‘Improvement’

Posted by in categories: biological, cyborgs, ethics, internet, robotics/AI, transhumanism

Well, Wesley J Smith just did another hit piece against Transhumanism.…provement/

It’s full of his usual horrible attempts to justify his intelligent design roots while trying to tell people he doesn’t have any religious reasons for it. But, then again, what can you expect from something from the National Review.

Sometimes you have to laugh. In “Transhumanism and the Death of Human Exceptionalism,” published in Aero, Peter Clarke quotes criticism I leveled against transhumanism from a piece I wrote entitled, “The Transhumanist Bill of Wrongs” From my piece:

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Mar 11, 2019

Bobby Brooke – The Potential of Thymus Regeneration

Posted by in categories: biotech/medical, life extension

Intervene Immune is a company focused on the age-related decline of the immune system, which is known as immunosenescence. Here, Bobby Brooke, CEO of Intervene Immune, discusses the clinical potential of regenerating the thymus as a means of reversing age-related immune system decline.

Earlier this year, we hosted the Ending Age-Related Diseases 2018 conference at the Cooper Union, New York City. This was a conference designed to bring together the best in the aging research and biotech investment worlds and saw a range of industry experts sharing their insights.

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Mar 11, 2019

The Relationship Between Longevity and Immunity

Posted by in categories: biotech/medical, life extension

There is a strong correlation between the decline of the immune system and a decrease in future lifespan. As the immune system performs a myriad of functions with a multitude of specialized cell types, its breakdown has serious ramifications for health and longevity. As we age, our immune systems steadily decline, becoming less efficient and more inclined to contribute to chronic inflammation due to inappropriate activation.

This smoldering chronic inflammation, also known as inflammaging, speeds up the development of various age-related diseases due to the crosstalk it has with the various damages of aging. In many ways, inflammaging is the glue that binds these damages together, as each of them has an inflammatory component and their progress is often accelerated in the presence of increased inflammation.

At a basic level, inflammation disrupts tissue maintenance and regeneration by blocking various repair pathways, so when that inflammation is chronic, as is commonly seen in aged individuals, the healing of organs and tissues is poor. Therefore, it is no surprise that chronic inflammation causes most older people to struggle to heal and recover from injury.

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Mar 11, 2019

We are happy to announce Dr. Nir Barzilai, Albert Einstein College of Medicine, as a speaker for the 2019 Undoing Aging Conference

Posted by in categories: biotech/medical, genetics, life extension

Dr. Barzilai is a chaired Professor of Medicine and Genetics and Director of the biggest Center in the world to study the Biology of Aging.

“Nir is our keynote speaker this year because, quite honestly, if I’d only given him half an hour there is no way he could do justice to his role in our movement. His scientific contributions have been world-leading for decades, but in recent years he has done so much more: he has taken a prominent role in two important rejuvenation startups, and he has also employed his exceptional political skills in forging invaluable new understandings between the biomedical gerontology and regulatory communities. Plus, he’s almost as entertaining a speaker as me!”, says Aubrey de Grey.

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Mar 11, 2019

Yaron Fuchs Awarded Sartorius & Science Prize

Posted by in categories: biotech/medical, life extension, science

Yaron Fuchs is the 2018 grand prize winner of the Sartorius & Science Prize for Regenerative Medicine & Cell Therapy, for work that reveals a role for programmed stem cell death in wound healing and tissue regeneration. The findings, described in his prize-winning essay, “The therapeutic promise of apoptosis,” could potentially pave the way to novel regenerative medicine and tumor therapies that target stem cells undergoing apoptosis — a type of programmed cell death.

The 2018 grand prize winner revealed a role for programmed stem cell death in wound healing and tissue regeneration, and potentially in tumor therapies.

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Mar 11, 2019

Tied up in red tape, Chinese scientists seek bigger say over research funding

Posted by in category: government

The authorities said the change was aimed at strengthening the government’s “research-driven development strategy” and “optimising the distribution of funding on science and technology”, while scientists said it meant funding approval would be more stringent.

Researchers say they spend so much time on grant applications that they get no time to do science.

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Mar 10, 2019

Anti-Aging Research: Science, not Hype

Posted by in categories: life extension, science

You’re cordially invited to the 1st of a series of blog entries I’m writing on anti-aging research smile

A: “It’s a dynamic system that veers away from its homeostasis (normal equilibrium point): hence a form of slow-progressing illness. Labeling it as ‘natural’ is a surrender to our traditional state of ignorance and powerlessness, which fortunately are beginning to be changed!”

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Mar 10, 2019

THE AOA PROBLEM – WHAT WE CAN DO ABOUT IT (reprinted from Curt Lewis Flight Safety Information News)

Posted by in category: transportation

In the wake of the October 29 Indonesian crash of a brand new Boeing 737 MAX 8 that took the lives of 189 passengers, the FAA has issued Emergency Airworthiness Directive (AD) 2018−23−51. The 737 is the most widely flown aircraft in the world, This tragedy opens an important conversation between regulators, operators and pilots.

Lion Air, an experienced 737 operator, was the launch carrier last year for the 737 MAX 8 and the MAX 9 in March. While it will take a long time to analyze the Lion Air 610 accident, the AD points out that current system architecture has created vulnerabilities.

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