Lifeboat Foundation

Clockwise from top left: ‘Hammer and Silicon’ authors Daniel Satinsky, Sheila Puffer, and Daniel McCarthy (Courtesy Sheila Puffer); scientist Slava Epstein (Adam Glanzman/ Northeastern University); Vladimir Torchilin, director of pharmaceutical biotechnology and nanomedicine at Northeastern University; anti-aging researcher at Harvard, Vadim Gladyshev (YouTube screenshot).

From cancer research to designing systems powering the Eiffel Tower, the unsung scientists, inventors and entrepreneurs found in the new book ‘Hammer and Silicon’ make an impact.

I remember the #DotCom crash all too well.

The publication record of health-care start-up companies doesn’t seem to matter to investors, according to an analysis of nearly 50 biomedical ‘unicorns’ — venture-capital-backed companies valued at more than US$1 billion. The analysis, led by health-policy researcher John Ioannidis at Stanford University in California, finds no correlation between a company’s market valuation and its publication record — defined as the number of peer-reviewed papers authored directly by a firm. That’s a cause for concern, the authors say.

Firms can achieve fêted ‘unicorn’ valuations without publishing much peer-reviewed science. Health-care start-ups can reach billion-dollar valuations without publishing in peer-reviewed journals, but skipping that step can catch them out.

Taking regular breaks to refresh the mind is important during tough working days. Although surfing the web and swiping your phone to check updates on social media might be frowned upon, it could be more productive than you think.

The popularity of social media has exploded since Twitter launched just over a decade ago, and the platform has distinguished itself as the place to disseminate tightly packed information with immediacy. Academics have jumped on the bandwagon for a range of practical purposes.

The social-media platform is often a tool for procrastination, says Jet-Sing M. Lee. But what else can it be? The social-media platform is often a tool for procrastination, says Jet-Sing M. Lee. But what else can it be?

The Salt Honey bees deal with many stressors: chemicals, climate change and viruses. But this year, a tiny mite has wiped out colonies, causing worry over whether there are enough bees left to do their jobs.

The rich levels of biodiversity on land seen across the globe today are not a recent phenomenon: diversity on land has been similar for at least the last 60 million years, since soon after the extinction of the dinosaurs.

According to a new study led by researchers at the University of Birmingham and involving an international team of collaborators, the number of species within ecological communities on land has increased only sporadically through geological time, with rapid increases in diversity being followed by plateaus lasting tens of millions of years.

Previously, many scientists have argued that diversity increased steadily through geological time, which would mean that biodiversity today is much greater than it was tens of millions of years ago. But building an accurate picture of how land diversity was assembled is challenging because the fossil record generally becomes less complete further back in time. By using modern computing techniques, capable of analysing hundreds of thousands of fossils, patterns are starting to emerge that challenge this view.

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What is the best approach for resuscitation of a patient with septic shock? Despite considerable investigation over several decades, this important question still has no clear answer. There is agreement that resuscitation should proceed quickly, for the longer the delay, the greater the physiologic stress and end-organ injury. However, treatment options are principally intravenous fluids and vasoactive agents, which have the capacity to both help or harm the patient. Thus, these therapies must be titrated in response to markers of the adequacy of resuscitation. The 2016 Surviving Sepsis Guidelines advocate that the principal marker of the adequacy of resuscitation is serum lactate. Serum lactate level is elevated when the body relies on anaerobic metabolism. As such, an elevated serum lactate level is a reflection of tissue hypoperfusion and thus considered axiomatic of shock. However, serum lactate level can be elevated in conditions other than shock and yet may not always be elevated in some shock states. Furthermore, lactate clearance is often considered too slow to provide timely feedback to clinicians regarding the consequences of their treatment decisions. Moreover, not all patients with shock can be cared for in settings with access to rapid-turnaround serum lactate assays.

An alternative approach is to monitor compensatory physiological mechanisms. For example, in response to shock, the body will attempt to restrict blood flow to peripheral vascular beds. Thus, one of the simplest bedside clinical examination findings in shock is delayed capillary refill in the skin. The problem with delayed capillary refill, however, is that the examination can be difficult to standardize. Furthermore, there has been little empirical evaluation of resuscitation strategies based on this finding.

In this issue of JAMA, Hernández and colleagues report the results of a clinical trial in which 424 adults with early septic shock were randomized to 2 alternative 8-hour resuscitation strategies: one based on serial measurements of serum lactate levels and the other on peripheral perfusion, assessed by serial capillary refill time (CRT) examinations. The trial was conducted among patients in the intensive care unit with early septic shock, defined as patients with suspected or confirmed infection who were recognized within 4 hours to have elevated serum lactate level (2 mmol/L) and require vasopressors to maintain blood pressure despite a bolus of 20 mL/kg of intravenous crystalloids.

A decade from now, memory-boosting implants could be available commercially, but at what risk?

Going to a clinic for a vaccine shot may no longer be necessary with this technology that’s now in development.

South China Morning Post February 19, 2019.

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