Lifeboat Foundation

Award Program Honors the Achievement.

MOUNTAIN VIEW November 11, 2019 — Sens Research Foundation has been selected for the 2019 Best of Mountain View Award in the Medical Laboratory category by the Mountain View Award Program.

Each year, the Mountain View Award Program identifies companies that we believe have achieved exceptional marketing success in their local community and business category. These are local companies that enhance the positive image of small business through service to their customers and our community. These exceptional companies help make the Mountain View area a great place to live, work and play.

Physicists use two types of measurements to calculate the expansion rate of the universe, but their results do not coincide, which may make it necessary to update the cosmological model. “It’s like trying to thread a cosmic needle,” explains researcher Licia Verde of the University of Barcelona, co-author of an article on the implications of this problem.

More than a hundred scientists met this summer at the Kavli Institute for Theoretical Physics at the University of California (U.S.) to try to clarify what is happening with the discordant data on the expansion rate of the universe, an issue that affects the very origin, evolution and fate of our cosmos. Their conclusions have been published in Nature Astronomy journal.

“The problem lies in the Hubble constant (H0), a parameter which value—it is actually not a constant because it changes with time—indicates how fast the Universe is currently expanding,” points out cosmologist Licia Verde, an ICREA researcher at the Institute of Cosmos Sciences of the University of Barcelona (ICC-UB) and the main author of the article.

ESA is getting serious about how hibernation could be used on long-duration space flights.

Artificial intelligence can be used to predict molecular wave functions and the electronic properties of molecules. This innovative AI method developed by a team of researchers at the University of Warwick, the Technical University of Berlin and the University of Luxembourg, could be used to speed-up the design of drug molecules or new materials.

Artificial intelligence and machine learning algorithms are routinely used to predict our purchasing behavior and to recognize our faces or handwriting. In scientific research, Artificial Intelligence is establishing itself as a crucial tool for scientific discovery.

In chemistry, AI has become instrumental in predicting the outcomes of experiments or simulations of quantum systems. To achieve this, AI needs to be able to systematically incorporate the fundamental laws of physics.

Although multicopter drones now are being used to transport medical samples and supplies, their 30-minute (or so) battery life limits their range. This week, however, a hydrogen-powered delivery drone managed a one-hour, 43-minute ocean crossing.

The exercise was the result of a collaboration between Texas-based drone development company Guinn Partners, Georgia-based Skyfire Consulting, the US Department of Health, and drone manufacturer Doosan Mobility Innovation – the latter supplied the aircraft, a hydrogen fuel cell-powered DS30 octocopter.

Utilizing its temperature-controlled payload system, the drone was used to transport live bacteria samples from a hospital on the Caribbean island of St. Croix to a testing facility on the neighboring island of St. Thomas. This involved crossing 43 miles (69 km) of open ocean. Upon successfully reaching its destination, the copter reportedly still had almost 30 minutes of flight time left on its fuel cell.

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In part two of this 2-part series, Oriana Beaudet and Dan Pesut discuss a healthcare future that includes automation, artificial intelligence and robots. And what about potential disruptive futures that change everything?

The evolution of human diets led to preferences toward polyunsaturated fatty acid (PUFA) content with ‘Western’ diets enriched in ω-6 PUFAs. Mounting evidence points to ω-6 PUFA excess limiting metabolic and cognitive processes that define longevity in humans. When chosen during pregnancy, ω-6 PUFA-enriched ‘Western’ diets can reprogram maternal bodily metabolism with maternal nutrient supply precipitating the body-wide imprinting of molecular and cellular adaptations at the level of long-range intercellular signaling networks in the unborn fetus. Even though unfavorable neurological outcomes are amongst the most common complications of intrauterine ω-6 PUFA excess, cellular underpinnings of life-long modifications to brain architecture remain unknown. Here, we show that nutritional ω-6 PUFA-derived endocannabinoids desensitize CB1 cannabinoid receptors, thus inducing epigenetic repression of transcriptional regulatory networks controlling neuronal differentiation. We found that cortical neurons lose their positional identity and axonal selectivity when mouse fetuses are exposed to excess ω-6 PUFAs in utero. Conversion of ω-6 PUFAs into endocannabinoids disrupted the temporal precision of signaling at neuronal CB1 cannabinoid receptors, chiefly deregulating Stat3-dependent transcriptional cascades otherwise required to execute neuronal differentiation programs. Global proteomics identified the immunoglobulin family of cell adhesion molecules (IgCAMs) as direct substrates, with DNA methylation and chromatin accessibility profiling uncovering epigenetic reprogramming at 1400 sites in neurons after prolonged cannabinoid exposure. We found anxiety and depression-like behavioral traits to manifest in adult offspring, which is consistent with genetic models of reduced IgCAM expression, to suggest causality for cortical wiring defects. Overall, our data uncover a regulatory mechanism whose disruption by maternal food choices could limit an offspring’s brain function for life.

• Immediate Communication
• Published: 18 November 2019

• Valentina Cinquina ¹,
• Daniela Calvigioni ¹,
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PHILADELPHIA—Stents and coronary artery bypass surgery are no more effective than intensive drug treatment and better health habits in preventing millions of Americans from heart attacks and death, a large study found, shedding new light on a major controversy in cardiology.

Researchers and doctors have fiercely debated for years how best to treat people who have narrowed coronary arteries but aren’t suffering acute symptoms.

The Times