Lifeboat Foundation

It’s common for people to focus on their health at the start of the year.

But few consider the well being of the microbes that live inside the human gut – the microbiome – which are vital to an individual’s good health.

How important are these bacteria? There are as many bacterial cells in us as there are human cells, and they help control everything from inflammation and the development and treatment of cancer to how much energy we get from our foods and perhaps even what foods we crave and our moods.

Unusual protein aggregates could have preserved the Iron Age brain.

For the first time, the agency’s Transiting Exoplanet Survey Satellite (TESS) has discovered a roughly Earth- planet in the habitable zone of its host star, the zone of orbital distances where liquid water could be stable on a world’s surface.

NASA’s TESS Planet Hunter Finds Its 1st Earth-Size World in ‘Habitable Zone’ : Read more

Interesting, perhaps pushing the paradigm limits here. 86% of solar energy is similar to Precambrian earth during the Faint Young Sun, a snow ball earth. Part of the report that is a bit confusing to me is the comment “One of the other planets is a red dwarf about 40% as massive, 40% as wide and 50% as hot as Earth’s sun.” I think this is about the host star being a red dwarf star. Red dwarfs can be flaring stars and cause problems for *habitable* exoplanets. The Sun spins about 2 km/s at the its equator, red dwarf stars can spin faster like 4 km/s or faster, rotation periods 1 day to 10 days so red dwarfs can emit more flares. The report does comment “In 11 months of data, we saw no flares from the star, which improves the chances TOI 700 d is habitable and makes it easier to model its atmospheric and surface conditions,” discovery team leader Emily Gilbert, a graduate student at the University of Chicago, said in the same statement.

The magnitude of the Great Lisbon Earthquake event, a historic and devastating earthquake and tsunami that struck Portugal on All Saints’ Day in 1755, may not be as high as previously estimated.

In his study published in the Bulletin of the Seismological Society of America, Joao F. B. D. Fonseca at the Universidade de Lisboa used macroseismic data—contemporaneous reports of shaking and damage—from Portugal, Spain and Morocco to calculate the earthquake’s magnitude at 7.7. Previous estimates placed the earthquake at magnitude 8.5 to 9.0.

Fonseca’s analysis also locates the epicenter of the 1755 earthquake offshore of the southwestern Iberian Peninsula, and suggests the rupture was a complicated one that may have involved faulting onshore as well. This re-evaluation could have implications for the seismic hazard map of the region, he said.

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X just launched its latest batch of Starlink internet satellites, and you might be able to spot the craft overhead if you know where to look.

The size of the human brain increased profoundly during evolution. A certain gene that is only found in humans triggers brain stem cells to form a larger pool of stem cells. As a consequence, more neurons can arise, which paves the way to a bigger brain. This brain size gene is called ARHGAP11B and so far, how it works was completely unknown. Researchers at the Max Planck Institute of Molecular Cell Biology and Genetics in Dresden now uncovered its mode of action. They show that the ARHGAP11B protein is located in the powerhouse of the cell—the mitochondria—and induces a metabolic pathway in the brain stem cells that is characteristic of cancer cells.

The research group of Wieland Huttner, a founding director of the Max Planck Institute of Molecular Cell Biology and Genetics, has been investigating the molecular mechanisms underlying the expansion of the brain during mammalian evolution for many years. In 2015, the group reported a key role for a gene that is only present in humans and in our closest extinct relatives, the Neanderthals and Denisovans. This gene, named ARHGAP11B, causes the so-called basal brain stem cells to expand in number and to eventually increase the production of neurons, leading to a bigger and more folded brain in the end. How the gene functions within the basal brain stem cells has been unknown so far.

Takashi Namba, a postdoctoral scientist in the research group of Wieland Huttner, wanted to find the answer to this question, together with colleagues from the Max Planck Institute, the University Hospital Carl Gustav Carus Dresden, and the Department of Medical Biochemistry at the Semmelweis University, Budapest. He found that the ARHGAP11B protein is located in mitochondria, the organelles that generate most of the cell’s source of chemical energy and hence are often referred to as the powerhouse of the cell. Takashi Namba explains the results: We found that ARHGAP11B interacts with a protein in the membrane of mitochondria that regulates a membrane pore. As a consequence of this interaction, the pores in the membrane are closing up, preventing calcium leakage from the mitochondria. The resulting higher calcium concentration causes the mitochondria to generate chemical energy by a metabolic pathway called glutaminolysis.

The company sees robots as life companions in what it calls the Age of Experience.

“Now we have a situation that is unique in modern history when they are trying to catch up to us,” he said. “Not a single country has hypersonic weapons, let alone hypersonic weapons of intercontinental range.”

The Pentagon and the U.S. military services have been working on the development of hypersonic weapons in recent years, and Defense Secretary Mark Esper said in August that he believes “it’s probably a matter of a couple of years” before the U.S. has one. He has called it a priority as the military works to develop new long-range fire capabilities.

The U.S. also has repeatedly warned Congress about hypersonic missiles being developed by Russia and China that will be harder to track and defeat. U.S. officials have talked about putting a layer of sensors in space to more quickly detect enemy missiles, particularly the more advanced hypersonic threats. The administration also plans to study the idea of basing interceptors in space, so the U.S. can strike incoming enemy missiles during the first minutes of flight when the booster engines are still burning.