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Feb 2, 2024

Team of astronomers discovers galaxy that shouldn’t exist

Posted by in category: cosmology

A team of astronomers, led by Arizona State University Assistant Research Scientist Tim Carleton, has discovered a dwarf galaxy that appeared in James Webb Space Telescope imaging that wasn’t the primary observation target.

Galaxies are bound together by gravity and made up of stars and planets, with vast clouds of dust and gas as well as dark matter. Dwarf galaxies are the most abundant galaxies in the universe, and are by definition small with low luminosity. They have fewer than 100 million stars, while the Milky Way, for example, has nearly 200 billion stars.

Recent observations of the abundance of “ultra-diffuse galaxies” beyond the reach of previous large spectroscopic surveys suggest that our understanding of the dwarf galaxy population may be incomplete.

Feb 2, 2024

A type of plastic that can be shape-shifted using tempering

Posted by in categories: biotech/medical, health, military

A team of molecular engineers have developed a type of plastic that can be shape-shifted using tempering. In their paper published in the journal Science the team, from the University of Chicago, with a colleagues from the US DEVCOM Army Research Laboratory, Aberdeen Proving Ground, the National Institutes of Standards and Technology and the NASA Glenn Research Center, describe how they made their plastic and how well it was able to shape shift when they applied various types of tempering.

Haley McAllister and Julia Kalow, with Northwestern University, have published a Perspective piece in the same issue of Science outlining the work.

Over the past several years, it has become evident that the use of plastics in products is harmful to not only the environment but also —bits of plastic have been found in the soil, the atmosphere, the oceans, and the human body.

Feb 2, 2024

Tracing the evolution of sign languages using computer modeling

Posted by in category: computing

An international team of linguistics experts has traced the origins of the most common modern sign languages using a computer model to compare them against one another. The research is published in the journal Science.

In this new effort, the research team noted that while studies have traced the linguistic history of written languages, little work has been done on the of sign languages. They state that there are more than 300 sign languages used by hearing-impaired people around the globe, and little is known about their origins or how they might have impacted one another.

Sign languages, like spoken and written languages, are unique to groups or cultures, with many corresponding to their written counterparts—there is a Spanish sign language, for example, and French, Spanish and Japanese.

Feb 2, 2024

A sleeker facial recognition technology tested on Michelangelo’s David

Posted by in categories: mobile phones, robotics/AI

Many people are familiar with facial recognition systems that unlock smartphones and game systems or allow access to our bank accounts online. But the current technology can require boxy projectors and lenses. Now, researchers report in Nano Letters a sleeker 3D surface imaging system with flatter, simplified optics. In proof-of-concept demonstrations, the new system recognized the face of Michelangelo’s David just as well as an existing smartphone system.

3D surface imaging is a common tool used in smartphone , as well as in computer vision and autonomous driving. These systems typically consist of a dot projector that contains multiple components: a laser, lenses, a light guide and a diffractive optical element (DOE).

The DOE is a special kind of lens that breaks the into an array of about 32,000 infrared dots. So, when a person looks at a locked screen, the facial recognition system projects an array of dots onto most of their face, and the device’s camera reads the pattern created to confirm the identity. However, dot projector systems are relatively large for small devices such as smartphones. So, Yu-Heng Hong, Hao-Chung Kuo, Yao-Wei Huang and colleagues set out to develop a more compact facial recognition system that would be nearly flat and require less energy to operate.

Feb 2, 2024

A camera-based anti-facial recognition technique

Posted by in category: robotics/AI

Facial recognition systems, computational tools that can recognize individuals in images or video footage, are now widely employed worldwide. Some users and developers, however, have raised privacy-related concerns, as by definition facial recognition techniques rely on images that capture people’s faces. It is possible to use facial recognition techniques to identify the person by his/her face without authorization.

Some recent computer science studies have thus been exploring the possibility of preventing unauthorized facial recognition recognizing users by obfuscating, synthesizing or changing images, to increase the privacy of users. This field of research is now broadly referred to as anti-facial recognition (AFR).

Researchers at USSLAB at Zhejiang University recently developed CamPro, a new technique designed to achieve AFR at the camera sensor level, producing images that can protect users’ facial privacy without influencing other applications, such as activity recognition. Their paper, accepted by NDSS 2024 and pre-published on the arXiv preprint server, demonstrates their proposed technique using images taken by widely available cameras.

Feb 2, 2024

Gene editing precisely repairs immune cells

Posted by in categories: bioengineering, biotech/medical, genetics

Some hereditary genetic defects cause an exaggerated immune response that can be fatal. Using the CRISPR-Cas9 gene-editing tool, such defects can be corrected, thus normalizing the immune response, as researchers led by Klaus Rajewsky from the Max Delbrück Center now report in Science Immunology.

Familial hemophagocytic lymphohistiocytosis (FHL) is a rare disease of the immune system that usually occurs in infants and under the age of 18 months. The condition is severe and has a high mortality rate. It is caused by various gene mutations that prevent cytotoxic T cells from functioning normally. These are a group of immune cells that kill virus– or otherwise altered cells.

If a child with FHL contracts a virus—such as the Epstein-Barr virus (EBV), but also other viruses—the cytotoxic T cells cannot eliminate the infected cells. Instead, the immune response gets out of control. This leads to a cytokine storm and an excessive inflammatory reaction that affects the entire organism.

Feb 2, 2024

Ridicule Erupts as Apple Reveals the Avatars in Its Super Expensive VR System

Posted by in category: virtual reality

Apple’s Vision Pro will be released on Friday, and reviews of the VR goggle’s custom digital avatars are already pouring: unsettling and bad.

Feb 2, 2024

Selection of Intriguing Nontraditional Funding Opportunities

Posted by in categories: innovation, life extension

During my pursuits, I’ve come across an increasing number of exciting nontraditional routes for funding scientific research. The efforts of Adam Marblestone and Benjamin Reinhardt have been particularly instrumental in stimulating this ecosystem, but many other great people have contributed as well. These new funding routes are a welcome relief since many of the most innovative and far-reaching projects are not especially suited for receiving governmental NIH, NSF, etc. funding. If you would like to find a more comprehensive list of such alternative funding sources, you should check out https://arbesman.net/overedge/. My own list (below) consists of funding sources that stand out to me as particularly promising. I hope you find this useful and feel free to reach out if you have any questions!

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Amaranthe Foundation https://amaranth.foundation/bottlenecks-of-aging “We outline initiatives which, if executed, could meaningfully accelerate the advancement of aging science and other life-extending technologies. The resulting document is a philanthropic menu, for which Amaranth is seeking both talent to execute on and co-funders. If you are a founder, researcher, or philanthropist interested in executing or co-sponsoring one or several of the projects or proposals below, please reach out to us”

Feb 2, 2024

The Disruptive Power of Advanced AI: A Profound Shift in Society

Posted by in category: robotics/AI

The advent of advanced artificial intelligence (AI) technologies is poised to bring about a significant upheaval in societal power dynamics. One of the notable transformations on the horizon is the potential disruption of the so-called “words” class. As AI continues to advance, it has the potential to limit the status and earning potential of individuals […].

Feb 2, 2024

Evolutionary trajectory of pattern recognition receptors in plants

Posted by in categories: biotech/medical, genetics

Plant cell-surface receptors that are known to participate in immunity, development, and reproductive processes include the LRR-, G-lectin-, Wall-associated kinase (WAK)-, Domain of Unknown Function 26 (Duf26)-, L-lectin-, Lysin motif (LysM)-, and Malectin-containing RLKs and RLPs (Fig. 1a–h). There are additional RLK families with different ectodomains, such as the proline-rich extensin-like receptor kinases (PERKs) and thaumatin-like protein kinases (TLPKs)9,13. However, their function in immunity is not well-characterized. Cell-surface receptors with LRR-, G-lectin-, WAK-, and LysM-ectodomains have been reported to recognise PAMPs, while others perceive self-molecules or unidentified ligands (Fig. 1h; Supplementary Fig. 1). Recognition of the diverse array of ligands is likely to be accomplished by variable structures and combinations of different ectodomains (Fig. 1a–g). To trace the origins of different receptor classes within the plant lineage, we first identified RLKs and RLPs in 350 genomes from Glaucophyta, red algae, green algae, Bryophytes, and Tracheophytes. We define here RLKs as any proteins with both 1–2 TMs and KDs, and RLPs as any protein with 1–2 TMs, but lack KDs. In total, we identified 177,645 RLKs, almost up to 70% of which possess either LRR-, G-lectin-, WAK-, Duf26-, L-lectin-, LysM-and Malectin-ectodomains (Fig. 1i). Next, we searched for proteins with these ectodomains and TMs that lack KDs and found 41,144 RLPs (Fig. 1j). We further examined which of the identified RLKs and RLPs families are likely to be involved in immunity. A previous report suggested a positive correlation between the gene family sizes of cell-surface immune receptors and intracellular immune receptors (the NB-ARC family) across the angiosperms4. We examined the correlation between the relative size (%; number of identified genes in the family/numbers of searched genes × 100; see methods) of the RLK families, the RLPs families, and the NB-ARC family in each genome. Notably, most RLK families (except for the LysM-RLKs) exhibit positive correlations with the NB-ARC family, while most RLP families (except for the LRR-RLPs) do not exhibit positive correlation with the NB-ARC family (Main Fig. 1k). Furthermore, we checked the expression level of these receptor families in Arabidopsis thaliana during immunity. Notably, the RLKs, except for LRR-and Malectin-RLKs, generally exhibit higher expression levels compared to the RLPs during immunity (Main Fig. 1k; Supplementary Fig. 2). These data collectively suggest that the RLKs are more likely to be involved in immunity than the RLPs.

Next, we examined the presence or absence of ectodomains (LRR-, G-lectin-, WAK-, Duf26-, L-lectin-, LysM-and Malectin-ectodomains lacking TM or KD; ectodomain-only proteins), RLPs (TM-bound ectodomains) and RLKs (ectodomains encompassing both TM and KD) in the plant lineage (Fig. 2; Supplementary Fig. 3; Supplementary Data 1a–c). Ectodomains exhibit an ancient heritage, with LRR-, WAK-, LysM-, Malectin-, and L-lectin-domains dating back to the era of Glaucophyta. Similarly, relatively ancient counterparts such as LRR-RLPs, WAK-RLPs, LysM-RLPs, Malectin-RLPs, and L-lectin-RLPs are found in both Glaucophyta and Rhodophyta. In contrast, RLKs emerged more recently. Green algae harbour WAK-RLKs, Malectin-RLKs, and G-lectin-RLKs, and LysM-RLKs, L-lectin-RLKs, and Duf-26-RLKs are exclusive to Embryophytes (Fig. 2). Except for LRR-RLPs, all six families of RLP are basal to the RLK families.

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