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Colorectal cancer (CRC) is a serious public health concern worldwide. Immune checkpoint inhibition medication is likely to remain a crucial part of CRC clinical management. This study aims to create new super paramagnetic iron oxide nano-carrier (SPION) that can effectively transport miRNA to specific CRC cell lines. In addition, evaluate the efficiency of this nano-formulation as a therapeutic candidate for CRC. Bioinformatics tools were used to select a promising tumor suppressor miRNA (mir-497-5p). Green route, using Fusarium oxyporium fungal species, manipulated for the synthesis of SPION@Ag@Cs nanocomposite as a carrier of miR-497-5p. That specifically targets the suppression of PD1/PDL1 and CTLA4pathways for colorectal therapy. UV/visible and FTIR spectroscopy, Zeta potential and MTT were used to confirm the allocation of the miR-497 on SPION@Ag@Cs and its cytotoxicity against CRC cell lines. Immunofluorescence was employed to confirm transfection of cells with miR-497@NPs, and the down-regulation of CTLA4 in HT29, and Caco2 cell lines. On the other hand, PDL1 showed a significant increase in colorectal cell lines (HT-29 and Caco-2) in response to mir497-5p@Nano treatment. The data suggest that the mir-497-loaded SPION@Ag@Cs nano-formulation could be a good candidate for the suppression of CTLA4in CRC human cell lines. Consequently, the targeting miR-497/CTLA4 axis is a potential immunotherapy treatment strategy for CRC.


Elfiky, A.M., Eid, M.M., El-Manawaty, M. et al. Sci Rep 15, 4,247 (2025). https://doi.org/10.1038/s41598-025-88165-3

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A series of experiments on board China’s space station have for the first time produced oxygen and the ingredients for rocket fuel – key steps that are considered essential for human survival and the future exploration of space.

The Shenzhou-19 crew aboard the Tiangong space station successfully conducted the world’s first in-orbit demonstration of artificial photosynthesis technology, producing oxygen, as well as the ingredients necessary for rocket fuel, paving the way for long-term space exploration, including a crewed moon landing before 2030.


Shenzhou-19 astronauts simulate natural photosynthesis, bringing long-haul crewed missions a step closer to reality.

Cardiomyocytes can be implanted to remuscularize the failing heart1,2,3,4,5,6,7. Challenges include sufficient cardiomyocyte retention for a sustainable therapeutic impact without intolerable side effects, such as arrhythmia and tumour growth. We investigated the hypothesis that epicardial engineered heart muscle (EHM) allografts from induced pluripotent stem cell-derived cardiomyocytes and stromal cells structurally and functionally remuscularize the chronically failing heart without limiting side effects in rhesus macaques. After confirmation of in vitro and in vivo (nude rat model) equivalence of the newly developed rhesus macaque EHM model with a previously established Good Manufacturing Practice-compatible human EHM formulation8, long-term retention (up to 6 months) and dose-dependent enhancement of the target heart wall by EHM grafts constructed from 40 to 200 million cardiomyocytes/stromal cells were demonstrated in macaques with and without myocardial infarction-induced heart failure. In the heart failure model, evidence for EHM allograft-enhanced target heart wall contractility and ejection fraction, which are measures for local and global heart support, was obtained. Histopathological and gadolinium-based perfusion magnetic resonance imaging analyses confirmed cell retention and functional vascularization. Arrhythmia and tumour growth were not observed. The obtained feasibility, safety and efficacy data provided the pivotal underpinnings for the approval of a first-in-human clinical trial on tissue-engineered heart repair. Our clinical data confirmed remuscularization by EHM implantation in a patient with advanced heart failure.


Epicardial engineered heart muscle allografts from induced pluripotent stem cell-derived cardiomyocytes can safely and effectively remuscularize chronically failing hearts in rhesus macaques, leading to improved cardiac function and paving the way for human clinical trials.

The ideal material for interfacing electronics with living tissue is soft, stretchable, and just as water-loving as the tissue itself—in short, a hydrogel. Semiconductors, the key materials for bioelectronics such as pacemakers, biosensors, and drug delivery devices, on the other hand, are rigid, brittle, and water-hating, impossible to dissolve in the way hydrogels have traditionally been built.

A paper published today in Science from the UChicago Pritzker School of Molecular Engineering (PME) has solved this challenge that has long stymied researchers, reimagining the process of creating hydrogels to build a powerful semiconductor in hydrogel form. Led by Asst. Prof. Sihong Wang’s research group, the result is a bluish gel that flutters like a sea jelly in water but retains the immense semiconductive ability needed to transmit information between living tissue and machine.


New material from the UChicago Pritzker School of Molecular Engineering can create better brain-machine interfaces, biosensors, and pacemakers.

If left unchecked, powerful AI systems may pose an existential threat to the future of humanity, say UC Berkeley Professor Stuart Russell and postdoctoral scholar Michael Cohen.

Society is already grappling with myriad problems created by the rapid proliferation of AI, including disinformation, polarization and algorithmic bias. Meanwhile, tech companies are racing to build ever more powerful AI systems, while research into AI safety lags far behind.

Without giving powerful AI systems clearly defined objectives, or creating robust mechanisms to keep them in check, AI may one day evade human control. And if the objectives of these AIs are at odds with those of humans, say Russell and Cohen, it could spell the end of humanity.

The advent of quantum simulators in various platforms8,9,10,11,12,13,14 has opened a powerful experimental avenue towards answering the theoretical question of thermalization5,6, which seeks to reconcile the unitarity of quantum evolution with the emergence of statistical mechanics in constituent subsystems. A particularly interesting setting is that in which a quantum system is swept through a critical point15,16,17,18, as varying the sweep rate can allow for accessing markedly different paths through phase space and correspondingly distinct coarsening behaviour. Such effects have been theoretically predicted to cause deviations19,20,21,22 from the celebrated Kibble–Zurek (KZ) mechanism, which states that the correlation length ξ of the final state follows a universal power-law scaling with the ramp time tr (refs. 3, 23,24,25).

Whereas tremendous technical advancements in quantum simulators have enabled the observation of a wealth of thermalization-related phenomena26,27,28,29,30,31,32,33,34,35, the analogue nature of these systems has also imposed constraints on the experimental versatility. Studying thermalization dynamics necessitates state characterization beyond density–density correlations and preparation of initial states across the entire eigenspectrum, both of which are difficult without universal quantum control36. Although digital quantum processors are in principle suitable for such tasks, implementing Hamiltonian evolution requires a high number of digital gates, making large-scale Hamiltonian simulation infeasible under current gate errors.

In this work, we present a hybrid analogue–digital37,38 quantum simulator comprising 69 superconducting transmon qubits connected by tunable couplers in a two-dimensional (2D) lattice (Fig. 1a). The quantum simulator supports universal entangling gates with pairwise interaction between qubits, and high-fidelity analogue simulation of a U symmetric spin Hamiltonian when all couplers are activated at once. The low analogue evolution error, which was previously difficult to achieve with transmon qubits due to correlated cross-talk effects, is enabled by a new scalable calibration scheme (Fig. 1b). Using cross-entropy benchmarking (XEB)39, we demonstrate analogue performance that exceeds the simulation capacity of known classical algorithms at the full system size.

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