Lifeboat Foundation: Safeguarding Humanity
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Blog – Page 7

New research by scientists at the University of Toronto and the Structural Genomics Consortium has deepened our understanding of how viruses like the flu, common cold, and COVID-19 get into cells in human airways.

Using the Canadian Light Source at the University of Saskatchewan, the researchers identified for the first time the crystal structures of a human protein (TMPRSS11D) that viruses use as a doorway into our body. The study is published in the journal Nature Communications.

Understanding how viruses use our proteins to gain entry into our cells will help researchers develop better ways to stop infections in their tracks.

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Current dental implants can work well, but they’re not perfect. They don’t attach to bones and gums in the same way that real teeth do. And around 20% of people who get implants end up developing an infection called peri-implantitis, which can lead to bone loss.

It is all down to the microbes that grow on them. There’s a complex community of microbes living in our mouths, and disruptions can lead to infection. But these organisms don’t just affect our mouths; they also seem to be linked to a growing number of disorders that can affect our bodies and brains. If you’re curious, read on.

The oral microbiome, as it is now called, was first discovered in 1670 by Antonie van Leeuwenhoek, a self-taught Dutch microbiologist. “I didn’t clean my teeth for three days and then took the material that had lodged in small amounts on the gums above my front teeth … I found a few living animalcules,” he wrote in a letter to the Royal Society at the time.

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Anyone who speculates on likely events ahead of time and prepares accordingly can react quicker to new developments. What practically every person does every day, consciously or unconsciously, is also used by modern computer processors to speed up the execution of programs. They have so-called speculative technologies which allow them to execute instructions on reserve that experience suggests are likely to come next. Anticipating individual computing steps accelerates the overall processing of information.

However, what boosts computer performance in normal operation can also open up a backdoor for hackers, as recent research by computer scientists from the Computer Security Group (COMSEC) at the Department of Information Technology and Electrical Engineering at ETH Zurich shows.

The computer scientists have discovered a new class of vulnerabilities that can be exploited to misuse the prediction calculations of the CPU (central processing unit) in order to gain unauthorized access to information from other processor users. They will present their paper at the 34th USENIX Security Symposium (USENIX 2025), to be held August 13–15, 2025, in Seattle.

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As more data is archived digitally, the inherent fragility of bits remains a pressing issue. The answer may lie in ceramics. Western Digital has invested in Cerabyte, a company developing a groundbreaking storage technology designed to preserve data reliably for millennia.

Cerabyte’s technology stores digital data on ceramic nanolayers, using lasers to etch QR code-like matrices representing bits. Ceramics, known for their resistance to corrosion and extreme heat, have endured for millennia. The German startup claims its storage method could preserve digital data for over 5,000 years.

Cerabyte recently demonstrated its technology’s durability by heating a prototype storage medium to 250°C in an oven. Both the medium and the archived data emerged unscathed. The company stated its ceramic-based solution could meet the rising demand for long-term data storage platforms.

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Researchers at UC Santa Barbara, UCSF and the University of Pittsburgh have developed a new workflow for designing enzymes from scratch, paving the way toward more efficient, powerful and environmentally benign chemistry. The new method allows designers to combine a variety of desirable properties into new-to-nature catalysts for an array of applications, from drug development to materials design.

This research is published in the journal Science, and is the result of a collaborative effort among the DeGrado lab at UCSF, the Yang lab at UCSB and the Liu lab at the University of Pittsburgh.

“If people could design very efficient enzymes from scratch, you could solve many important problems,” said UCSB chemistry professor Yang Yang, a senior author on the paper.

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Sustainably produced, biodegradable materials are an important focus of modern materials science. However, when working with natural materials such as cellulose, lignin or chitin, researchers face a trade-off. Although these substances are biodegradable in their pure form, they are often not ideal when it comes to performance. Chemical processing steps can be used to make them stronger, more resistant or more supple—but in doing so, their sustainability is often compromised.

Empa researchers from the Cellulose and Wood Materials laboratory have now developed a bio-based material that cleverly avoids this compromise. Not only is it completely biodegradable, it is also tear-resistant and has versatile functional properties. All this takes place with minimal processing steps and without chemicals—you can even eat it. Its secret: It’s alive.

The study is published in the journal Advanced Materials.

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In Biology 101, we learn that RNA is a single, ribbon-like strand of base pairs that is copied from our DNA and then read like a recipe to build a protein. But there’s more to the story. Some RNA strands fold into complex shapes that allow them to drive cellular processes like gene regulation and protein synthesis, or catalyze biochemical reactions.

We know that these active molecules, called non-coding RNAs, are present in all life forms, yet we’re just starting to understand their many roles—and how they can be harnessed for applications in environmental science, agriculture, and medicine.

To study—and potentially modify—the functions of non-coding RNAs, we need to determine their structure. Scientists from Lawrence Berkeley National Laboratory (Berkeley Lab) and the Hebrew University of Jerusalem have developed a streamlined process that predicts the structure of an RNA molecule down to the atomic level.

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