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SpaceX appears to have successfully fired up its fourth full-scale Starship prototype for the third time, although the Raptor engine test ended with the aft end of the ship catching fire and burning for quite some time.

Around May 7th, hours after Starship SN4 completed its second wet dress rehearsal and Raptor static fire in ~24 hours, SpaceX removed the SN18 Raptor engine it had used to support those tests, transporting it back to storage facilities a mile down the road. Three days later, SpaceX sent Raptor SN20 down the same same road and installed it on Starship SN4 – a swap made for unknown reasons.

Regardless, that swap meant that SpaceX would need to perform at least one more static fire test to prove that Starship and its new Raptor engine were getting along before the company could proceed to hop test preparations. After several days of at least 4 aborted Starship static fire attempts, SpaceX has finally managed to fuel Starship SN4 and ignite Raptor engine SN20 – but not before a new challenge cropped up.

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AURORA, Colo. (KDVR) — A man has been charged with attempted murder for allegedly shooting a Waffle House employee in Aurora one night after being asked to wear a face covering inside the restaurant.

Kelvin Watson, 27, was arrested Monday morning by the Aurora Police Department on a charge of attempted first-degree murder.

Employees at the Waffle House at 12880 E. Mississippi Ave. told police that Watson came to the restaurant shortly after midnight on May 14 and was not wearing a mask, according to an arrest affidavit. A waitress told Watson he needed to have a mask on or he could not be served, the court document says. The restaurant was offering carry-out orders.

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The pandemic COVID-19 has spread to all over the world and greatly threatens safety and health of people. COVID-19 is highly infectious and with high mortality rate. As no effective antiviral treatment is currently available, new drugs are urgently needed. We employed transcriptional analysis to uncover potential antiviral drugs from natural products or FDA approved drugs. We found liquiritin significantly inhibit replication of SARS-CoV-2 in Vero E6 cells with EC50 = 2.39 μM. Mechanistically, we found liquiritin exerts anti-viral function by mimicking type I interferon. Upregulated genes induced by liquiritin are enriched in GO categories including type I interferon signaling pathway, negative regulation of viral genome replication and etc. In toxicity experiment, no death was observed when treated at dose of 300 mg/kg for a week in ICR mice. All the organ indexes but liver and serum biochemical indexes were normal after treatment. Liquiritin is abundant in licorice tablet (~0.2% by mass), a traditional Chinese medicine. Together, we recommend liquiritin as a competitive candidate for treating COVID-19. We also expect liquiritin to have a broad and potent antiviral function to other viral pathogens, like HBV, HIV and etc.

The authors have declared no competing interest.

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A gene therapy trial performed on mice may foreshadow yet another way to hack fitness. In a study done by a team at Washington University in St. Louis’ medical school, mice quickly built muscle mass and reduced obesity after receiving the therapy, even while eating a diet high in fat and not exercising. The results were published last week in a paper in Science Advances.

The gene targeted was FST, which is responsible for making a protein called follistatin. In humans and most other mammals, follistatin helps grow muscle and control metabolism by blocking a protein called myostatin, which acts to restrain muscle growth and ensure muscles don’t get too big.

The researchers injected eight-week-old mice with a virus carrying a healthy FST gene (gene therapy involves adding healthy copies of a gene to cells, usually using a virus as a deliveryman).

Over a period of 18 weeks, or about 4 months, the team observed that the muscle mass of the treated mice more than doubled, as did their strength level. They also experienced reduced damage related to osteoarthritis, less inflammation in their joints, and had healthier hearts and blood vessels than mice that didn’t receive the gene therapy —even though all the mice ate the same high-fat diet and did the same amount of exercise.

Continue reading “Forget Exercise—These Mice Got Ripped With Gene Therapy” | >

It’s 2020. Why can’t we binge Netflix as our cars drive us down the highway? Well, we’ve made progress, but not at the pace once promised. While some cars offer automated driving modes, you’re not to take your eyes off the road or hands from the wheel. Volvo wants to remedy that.

The company isn’t promising 100% self-driving cars in the near future. Instead, they’ll make mainstream cars that reliably drive themselves on highways—totally autonomously, no human attention needed. For a brand built on safety, and in light of autopilot accidents in recent years, it’s notable the company thinks that’s possible in the not-too-distant future.

To make it happen, Volvo said this week that it would begin adding lidar to production cars in 2022. They’ll also develop self-driving software to integrate lidar, cameras, radar, and back-up vehicle control systems. Once the software, dubbed Highway Pilot, is deemed safe, it’ll be sent out as an update to customers who opt in.

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This raises the question of whether AI — defined as algorithms that mimic human intelligence — can deliver on its potential, and when. The answer is crucial because AI could become the ultimate industry disrupter, threatening tens of millions of jobs in Asia as business processes are automated. In addition, AI is the subject of intense rivalry between the US and China.

Unicorns abound but enthusiasm has dimmed. Will AI fulfil its potential?

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INDIANAPOLIS (WISH) — First is was monkeys, then dogs.

Now, researchers are turning to cows in hopes of developing a treatment for the coronavirus.

Scientists at SAb Biotherapeutics in South Dakota created an embryo via genetic engineering that contains human chromosomes. The embryo was then implanted into cattle. The cows gave birth to calves that internally function similarly to a person, specifically with regards to the human immune system.

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Circa 2019

Airless tires for everyday cars might soon be far more practical. GM and Michelin have unveiled a prototype of Uptis (Unique Puncture-proof Tire System), a Michelin-made tire intended for passenger cars. It looks like Tweel and other air-free concepts of years past, but its mix of composite rubber and resin embedded fiberglass lets it operate at highway speeds — earlier options tend to work only when you’re slowly putting around. It’s not as visually appealing as conventional tires, but Michelin claims it’s just as comfortable.

More importantly, there’s a tangible roadmap. GM will start testing the Uptis in Michigan later in 2019 on a fleet of Chevy Bolts, and expects the finished version to reach production cars as soon as 2024. The automaker hasn’t named specific car models that will use the new tires.

Continue reading “GM and Michelin will bring airless tires to passenger cars by 2024” | >