Lifeboat Foundation

It turns out the gut is full of surprises. And one of those surprises may have offered up a key for unlocking a new way of treating multiple sclerosis (MS). Investigators from Brigham and Women’s Hospital have discovered a microRNA—a small RNA molecule—that increases during peak disease in a mouse model of MS and in untreated MS patients. When a synthetic version of the microRNA was orally given to the mice, it prevented disease. While several steps remain before these insights can be translated into therapy for patients, the researchers describe their results as both exciting and unexpected. Their findings are published in Cell Host & Microbe.

“We’ve discovered a new mechanism to regulate the microbiome and treat human disease that hadn’t been known before,” said senior author Howard Weiner, MD, co-director of the Ann Romney Center for Neurologic Diseases at the Brigham. “The gut microbiome is known to play an important role in MS and other diseases. Our findings, which show that a microRNA can be used to target and influence the microbiome with precision, may have applicability for MS and many other diseases, including diabetes, ALS, obesity and cancer.”

Weiner, lead author Shirong Liu, MD, Ph.D., an instructor in the Weiner laboratory, and their colleagues investigated how the altered gut microbiome affects the course of MS. To do so, they studied the microbiome and microRNAs found in the experimental autoimmune encephalomyelitis (EAE) model of MS. Unexpectedly, they found that when they transferred fecal matter from EAE mice at peak disease, it protected the mice who received the transfer. The team found that a specific microRNA, known as miR-30d, rather than live bacteria, was responsible for preventing disease. The investigators found that miR-30d is enriched in untreated, relapsing-remitting MS patients as well.

Essentially good layers of sediment can decrease earthquake frequency.

Central information platform on natural hazards and their management in Switzerland. Background information about different types of natural hazards, information for experts/authorities and images, publications, information about events, links and much more.

This would solve California’s earthquake problem.

H2020,coquake, ERC-2017-STG, ECOLE NATIONALE DES PONTS ET CHAUSSEES(FR)

Yay face_with_colon_three

The pressure of deep-ocean sound waves could be used to stop tsunamis in their tracks, researchers have found, by dissipating their energy across wider areas and reducing the height and speed of these monster waves before they reach land.

Tsunamis — which can be caused by earthquakes, landslides, or any sudden release of energy underwater — are capable of devastating coastal regions when they hit land, and right now, there’s not much we can do to stop them.

Continue reading “A Mathematician Says He’s Found a System That Could Stop Tsunamis in Their Tracks” »

Recently, Libella Gene Therapeutics has announced that it will be running a patient-paid trial in Colombia with an eye-watering $1 million USD price tag on enrollment.

Patient-paid trial likely to cause backlash

The topic of patient-paid trials often stirs up considerable debate among the research community, regulatory authorities, and the general public, with many people suggesting that it is unethical to expect patients to pay to participate in clinical trials. While this is a controversial issue, these trials are a legitimate way to test therapies that would otherwise struggle to reach the clinic due to cost constraints, and the data gathered by such trials can still be valuable.

The study saw the deployment of a multiple target gene therapy focused on 3 known longevity genes delivered via an adeno-associated virus. The focus was on mitigating T2 diabetes, heart failure, and kidney failure in mouse models with very positive results observed. Join us on Tuesday, 26th November, 1pm EDT on our Facebook page for the livestream show.

O.o…

The communications system of Mexico’s oil giant Pemex is still suffering the lingering effects of a cyberattack that occurred earlier this month, sources from the company told Bloomberg.

A ransomware attack caused administrative operations at Pemex to grind to a halt on November 10, with the company announcing the resumption of work soon after, saying the actual attack had been prevented.

Continue reading “Pemex Still Suffers Cyberattack Fallout” »

In Technion, Bar-Ilan trials, nanochip ferries ‘neural growth factor’ — which combats neurodegenerative diseases — and releases it where needed, overcoming blood-brain barrier.

“We want a new space race—space races are exciting,” declared SpaceX founder Elon Musk after the successful inaugural flight last year of the Falcon Heavy, the most powerful rocket since the Space Shuttle.

Hawks and headline writers think space races are exciting too, especially the “new space race” between China and the United States. That’s why they keep referring to it—even though it doesn’t exist.

Historic changes are indeed afoot in the space sector. Private crewed spaceflight is about to come of age. Mobile robotic spacecraft are being built to rendezvous with satellites to service them. Vast swarms of broadband satellites are set to make the Internet truly global for the first time, and increase the number of spacecraft in orbit tenfold. Back on Earth, satellite imagery fed through artificial intelligence algorithms promises powerful insights into all manner of human activity. Dozens of countries are active in space and the number is growing all the time. The tired trope of the superpower space race does little to make sense of all this.