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Apr 26, 2019

Adult Cardiac Stem Cell Aging: A Reversible Stochastic Phenomenon?

Posted by in categories: biotech/medical, life extension, robotics/AI

Aging is by far the dominant risk factor for the development of cardiovascular diseases, whose prevalence dramatically increases with increasing age reaching epidemic proportions. In the elderly, pathologic cellular and molecular changes in cardiac tissue homeostasis and response to injury result in progressive deteriorations in the structure and function of the heart. Although the phenotypes of cardiac aging have been the subject of intense study, the recent discovery that cardiac homeostasis during mammalian lifespan is maintained and regulated by regenerative events associated with endogenous cardiac stem cell (CSC) activation has produced a crucial reconsideration of the biology of the adult and aged mammalian myocardium. The classical notion of the adult heart as a static organ, in terms of cell turnover and renewal, has now been replaced by a dynamic model in which cardiac cells continuously die and are then replaced by CSC progeny differentiation. However, CSCs are not immortal. They undergo cellular senescence characterized by increased ROS production and oxidative stress and loss of telomere/telomerase integrity in response to a variety of physiological and pathological demands with aging. Nevertheless, the old myocardium preserves an endogenous functionally competent CSC cohort which appears to be resistant to the senescent phenotype occurring with aging. The latter envisions the phenomenon of CSC ageing as a result of a stochastic and therefore reversible cell autonomous process. However, CSC aging could be a programmed cell cycle-dependent process, which affects all or most of the endogenous CSC population. The latter would infer that the loss of CSC regenerative capacity with aging is an inevitable phenomenon that cannot be rescued by stimulating their growth, which would only speed their progressive exhaustion. The resolution of these two biological views will be crucial to design and develop effective CSC-based interventions to counteract cardiac aging not only improving health span of the elderly but also extending lifespan by delaying cardiovascular disease-related deaths.

Over the last decades, average life expectancy has significantly increased worldwide although several chronic diseases continue to grow, with aging as their main risk factor [1]. Aging is a natural and inevitable degenerative process of biological functions characterized by the progressive decline in tissue and organ homeostasis and function. Despite the significant improvements in diagnosis and treatment, the majority of individuals older than 65 years of age suffer from an elevated risk to develop cardiovascular diseases (CVDs), with a decline in the quality of life and in the ability to perform the normal activities of daily living [1]. Aging produces numerous changes in the human heart at structural, molecular, and functional levels [2].

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Apr 26, 2019

The Glass Age, Part 1: Flexible, Bendable Glass

Posted by in categories: innovation, materials

Circa 2014


Be amazed as Adam Savage and Jamie Hyneman introduce us to a whole new way of thinking about glass. Learn the history of glass innovation and watch incredible demonstrations of bendable optical fiber and thin, ultra-flexible glass. This is the Glass Age, where materials science is constantly pushing boundaries and creating new possibilities for glass-enabled technology and design. See how glass is shaping the future at www.TheGlassAge.com

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Apr 26, 2019

How do you film the Speed of Light?

Posted by in category: entertainment

It’s not easy to film light itself. Gav and Dan learn how it’s done from the experts.

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Apr 26, 2019

Astronomers Just Detected The Universe Is Expanding Much Faster Than It Should Be

Posted by in category: cosmology

The latest measurement of the expansion rate of the Universe is in, and it has confirmed with more certainty than ever that we have a real dilly of a pickle on our hands. Once again, the result has shown that the Universe is expanding much faster than it should be based on the conditions just after the Big Bang.

The Universe’s rate of expansion is called the Hubble Constant, and it’s been incredibly tricky to pin down.

According to data from the Planck satellite that measured the cosmic microwave background (the conditions of the early Universe just 380,000 years after the Big Bang, the Hubble Constant should be 67.4 kilometres (41.9 miles) per second per megaparsec, with less than 1 percent uncertainty.

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Apr 26, 2019

Philip Tedeschi, Director, Institute for Human-Animal Connection — Ira Pastor — IdeaXme

Posted by in categories: aging, biological, biotech/medical, DNA, futurism, genetics, habitats, health, life extension, neuroscience

Apr 26, 2019

Futuristic inventions and emerging technologies that will change the world

Posted by in categories: futurism, innovation

What do the inventions of the future look like?

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Apr 26, 2019

An Algal Parasite Contains Functional Mitochondria Without DNA

Posted by in categories: biotech/medical, genetics

A recent study has suggested that A.Ceratii, a parasite that feeds on small life forms, including the ones that form algal blooms, contains mitochondria that have no mitochondrial DNA, and at least some of this DNA is found in the parasite’s own genetic code. However, a few genes found in humans are missing and replaced with alternatives [1].

What are mitochondria?

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Apr 26, 2019

Burzynski: The Cancer Cure Cover Up (Cancer Documentary) | Full Documentary | Reel Truth

Posted by in categories: biotech/medical, education, government, law

A documentary by Eric Merola

Burzynski: The Cancer Cure Cover-up is the story of a pioneering biochemist who discovered a unique and proprietary method of successfully treating most cancers. This documentary takes the audience on a near 50-year journey both Dr. Burzynski and his patients have been enduring in order to obtain FDA-approved clinical trials of Antineoplastons. Defying the face of skepticism, legal attacks from state and federal agencies, and a powerful propaganda campaign to stop Burzynski – this doctor and his patients are still going strong.

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Apr 26, 2019

What if a jolt of electricity could make you happy?

Posted by in category: neuroscience

Scientists found a way to tap into a brain region called the cingulum and activate unbridled joy.

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Apr 26, 2019

Researchers discover surprising quantum effect in hard disk drive material

Posted by in categories: materials, quantum physics

Scientists find surprising way to affect information storage properties in metal alloy.

Sometimes scientific discoveries can be found along well-trodden paths. That proved the case for a cobalt-iron alloy material commonly found in .

As reported in a recent issue of Physical Review Letters, researchers from the U.S. Department of Energy’s (DOE) Argonne National Laboratory, along with Oakland University in Michigan and Fudan University in China, have found a surprising quantum effect in this alloy.

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