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Blog – Page 7665

The US Food and Drug Administration (FDA) has approved viltolarsen (Viltepso; NS Pharma) for the treatment of patients with Duchenne muscular dystrophy amenable to exon 53 skipping, making it only the second FDA-approved therapy for this specific DMD gene mutation.

The agent from NS Pharma, delivered via weekly intravenous infusion, was granted accelerated approval via its priority review, fast track, orphan drug, and rare disease designations after its new drug application was accepted earlier this year. In March, NS Pharma launched an expanded access program for qualified patients.

The approval was granted based on findings from a phase 2 clinical trial (NCT02740972) and long-term extension study, details of which were recently published in JAMA Neurology. Among 16 participants age 4 to 9, significant drug-induced dystrophin production was observed in both viltolarsen dose cohorts (40 mg/kg per week: mean, 5.7% [range, 3.2–10.3] of normal; 80 mg/kg per week: mean, 5.9% [range, 1.1–14.4] of normal), with 15 (94%) patients achieving dystrophin levels greater than 2% of normal and 14 of 16 (88%) achieving levels greater than 3% of normal.

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China’s Xiaomi has launched a new TV as part of the 10th anniversary celebration that also saw the announcement of the Mi 10 Ultra smartphone. The Mi TV Lux Transparent Edition brings sci-fi into the living room with an edge-to-edge self-luminous television that you can see through.

We’ve seen a few transparent televisions and screens from industry big hitters like Samsung, LG and Panasonic over the years, but Xiaomi says its Mi TV Lux Transparent Edition is the first to go into mass production.

The 55-inch OLED panel is just 5.7-mm thin and sits on a rounded base and, when the TV isn’t powered on, the display looks like a window between you and whatever is behind it – though it can be set to show arty display images if desired. But Xiaomi is promising an “unprecedented visual experience” when it’s switched on, with “extra rich blacks and unmatched brightness.”

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Scientists from Nanyang Technological University, Singapore (NTU Singapore) have developed an Artificial Intelligence (AI) system that recognizes hand gestures by combining skin-like electronics with computer vision.

The recognition of human by AI systems has been a valuable development over the last decade and has been adopted in high-precision surgical robots, health monitoring equipment and in .

AI recognition systems that were initially visual-only have been improved upon by integrating inputs from wearable sensors, an approach known as ‘data fusion’. The wearable sensors recreate the skin’s sensing ability, one of which is known as ‘somatosensory’.

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A team of researchers working at the University of Maryland has uncovered the structure of the mysterious blue whirling flame. In their paper published in the journal Science Advances, the group describes using computer simulations to determine the structure of the unique type of flame.

Back in 2016, a team of researchers discovered what they described as a blue whirling flame while they were studying the properties of liquid fuel floating on water. They had added fuel to a tank full of water that was enclosed in a space that generated a vortex. They described a fire that looked at first like a tornado, but then shortly after, settled into what they dubbed a blue whirling flame. They noted at the time that its color suggested it likely was very efficient, burning the fuel without creating soot—a property that might be useful in cleaning up oil spills. Since then, others have looked at the unique type of flame, but no one had tried to understand its . In this new effort, the researchers took a closer look at the flame and found it was actually three types of flames that had merged into one.

To learn more about the nature of the blue whirling flame, the researchers created using conditions known to generate them. They then slowly adjusted the parameters until they were able to generate the flame virtually. They discovered that the flame was actually the result of three known types of flames merging: those with an invisible outer flame, which happens when there is less fuel than oxygen in the mix—and two that had types of visible inner flames in which higher ratios are more common.

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