Lifeboat Foundation

Circa 2001

DNA methylation is a major epigenetic modification of the genome that regulates crucial aspects of its function. Genomic methylation patterns in somatic differentiated cells are generally stable and heritable. However, in mammals there are at least two developmental periods—in germ cells and in preimplantation embryos—in which methylation patterns are reprogrammed genome wide, generating cells with a broad developmental potential. Epigenetic reprogramming in germ cells is critical for imprinting; reprogramming in early embryos also affects imprinting. Reprogramming is likely to have a crucial role in establishing nuclear totipotency in normal development and in cloned animals, and in the erasure of acquired epigenetic information. A role of reprogramming in stem cell differentiation is also envisaged.

DNA methylation is one of the best-studied epigenetic modifications of DNA in all unicellular and multicellular organisms. In mammals and other vertebrates, methylation occurs predominantly at the symmetrical dinucleotide CpG (1–4). Symmetrical methylation and the discovery of a DNA methyltransferase that prefers a hemimethylated substrate, Dnmt1 , suggested a mechanism by which specific patterns of methylation in the genome could be maintained. Patterns imposed on the genome at defined developmental time points in precursor cells could be maintained by Dnmt1, and would lead to predetermined programs of gene expression during development in descendants of the precursor cells (5, 6). This provided a means to explain how patterns of differentiation could be maintained by populations of cells. In addition, specific demethylation events in differentiated tissues could then lead to further changes in gene expression as needed.

Continue reading “Epigenetic Reprogramming in Mammalian Development” »

After twenty five years of research, scientists at the Massachusetts Institute of Technology think that they have finally cracked the code for the commercialization for nuclear fusion reactions.

Commonwealth Fusion Systems is the fruit of that research. It’s a startup building on decades of research and development that plans to harness the power of the sun to create a cleaner, stable source of energy for consumers. And the company just raised another $50 million in funding from some of the country’s deepest pocketed private investors to continue on its path to commercialization.

The company unveiled its technology and a first $64 million in financing from investors including the Italian energy company, Eni; Breakthrough Energy Ventures, the investment consortium established by the world’s richest men and women, and The Engine, MIT’s own investment vehicle for frontier technologies.

Photography measures how much light of different color hits the photographic film. However, light is also a wave, and is therefore characterized by the phase. Phase specifies the position of a point within the wave cycle and correlates to depth of information, meaning that recording the phase of light scattered by an object can retrieve its full 3D shape, which cannot be obtained with a simple photograph. This is the basis of optical holography, popularized by fancy holograms in sci-fi movies like Star Wars.

But the problem is that the spatial resolution of the photo/hologram is limited by the wavelength of light, around or just-below 1 μm (0.001 mm). That’s fine for macroscopic objects, but it starts to fail when entering the realm of nanotechnology.

Continue reading “New holographic technique opens the way for quantum computation” »

An all-star panel of experts in nutritional studies with an emphasis on longevity. At some point in your life, you have heard the following. “Eat the right food. It will help you live longer.” What if I told you the right food could help you heal as well. This panel of longevity driven nutritionist will give you a broad range of fact-based regiments and compelling individual opinions on Nutrition and longevity.
This segment will cover many diverse understandable methods that can make a change in longevity for you or your loved ones. Fill yourself with the knowledge of proper nutrition for longevity.

Speakers Will Include:
Brian Clement – Plant-Based & founder of “Hippocrates Health Institute”
A typical American growing up in the New Jersey/New York area, Brian likes to joke that he was a pioneer in the field of obesity—he was fat even before many Americans were fat! Raised in an Irish household on the standard American diet of meat, processed foods, and sugary sodas, he was unfit and gasping for air every few steps. When he was 20 years old, he was dating a girl whose best friend’s boyfriend was 30—and a vegetarian. Despite the fact he had been more or less educated by his family that the body would die without animal-based foods, the lure of an influential peer inspired him to give up meat in one fell swoop. For the first year and a half, he kept his vegetarian diet a secret from his family. Yet after losing 120 pounds and experiencing the difference in his health, he came out of the proverbial closet (much to his family’s dismay!) and became a complete vegan three years later.

Continue reading “Nutrition for Longevity” »

AI Simulates the Universe, including amount of dark matter.

The chosen mission—Dragonfly—beat out eleven competitors.

It’s already theoretically possible to bring back mammoths.

The oldest plant ever to be regenerated has been grown from 32,000-year-old seeds—beating the previous recordholder by some 30,000 years. (Related: “‘Methuselah’ Tree Grew From 2,000-Year-Old Seed.”)

A Russian team discovered a seed cache of Silene stenophylla, a flowering plant native to Siberia, that had been buried by an Ice Age squirrel near the banks of the Kolyma River (map). Radiocarbon dating confirmed that the seeds were 32,000 years old.

The mature and immature seeds, which had been entirely encased in ice, were unearthed from 124 feet (38 meters) below the permafrost, surrounded by layers that included mammoth, bison, and woolly rhinoceros bones.