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The new structure works by mapping the backbones of amino acids to locations of chemicals in the Protein Data Bank involved in interactions with them. The researchers note that only recently has the data bank come to hold enough information to allow for its use in such an application. And they also note that the technique and structure can also be used to produce delivery vehicles based on proteins and also small molecule applications…

A pair of researchers at the University of California, San Francisco, has developed a new protein structure that allows for simplifying the process of custom-designing proteins. In their paper published in the journal Science, Nicholas Polizzi and William DeGrado discuss their structural unit and how they used it. Anna Peacock, with the University of Birmingham, has published a Perspective piece outlining the work by the team in California in the same journal issue.

One of the things that chemists are asked to do is custom design proteins for use in certain special applications. As the researchers note, doing so is considered to be very challenging. It usually involves a considerable amount of trial and error which generally translates to high development costs. In this new effort, the researchers have devised a new unit of to help with such projects. They call it a van der Mer and describe how it can be used to directly map ligand chemical group functionality to peptide residue backbone coordinates.

To come up with the new structure, the research pair poured through and analyzed thousands of structures in the Protein Data Bank. Their approach differed from the norm in that they ignored the positioning of side chains for the amino acid residue and instead focused on the chemical groups that contacted the residues. Using this method, they were able to design two new proteins that could be used to identify a drug called apixaban. Notably, their approach involved making just six sequences. Prior to their work, such a process would have typically taken many more.

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Cooking foods at temperatures higher than boiling produces advanced glycation end (AGE) products, which induce insulin resistance and inflammation, and shorten lifespan in mice. Similar data exists in humans for the effect of AGE products on insulin resistance and inflammation, and a higher dietary AGE product intake is associated with cancer in both men and women. Accordingly, reducing dietary AGE product intake may be an important strategy for improving health and increasing lifespan in people.

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The most massive black hole collision ever detected has been directly observed by the LIGO and VIRGO Scientific Collaboration, which includes scientists from The Australian National University (ANU).

The short gravitational wave signal, GW190521, captured by the LIGO and Virgo gravitational wave observatories in the United States and Europe on May 21 last year, came from two highly spinning, mammoth black holes weighing in at a massive 85 times and 66 times the mass of the Sun, respectively.

But that is not the only reason this system is very special. The larger of the two black holes is considered “impossible.” Astronomers predict that stars between 65 – 130 times the mass of the Sun undergo a process called pair instability, resulting in the star being blown apart, leaving nothing behind.

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Scientists claim they have observed a fifth force of nature that could transform our understanding of how the universe works.

Researchers at the Hungarian Academy of Sciences have revealed results that could show it in action.

They saw an excited, decaying helium atom emit light when the particles split in a strange way that could not be explained by the current understanding of physics.

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The achievement opens a pathway for development of the first practical and efficient devices to generate and detect light at terahertz wavelengths—between and microwaves. Such devices could be used in applications as diverse as communications in outer space, cancer detection, and scanning for concealed weapons.

The research could also enable exploration of the basic physics of matter at infinitesimally small scales and help usher in an era of quantum metamaterials, whose structures are engineered at atomic dimensions.

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The cosmos was born in a churning fluid 300 million times hotter than the sun. We’ve recreated this hell, and it’s not just hot, it is also very, very strange, says Amanda Gefter (science writer based in London). TO LOOK deep into the fundamental structure of matter is to look billions of years back in time, to the moment when matter first blinked into being. Recreating the conditions of that moment has long been an aim for physicists wanting to understand how the universe evolved from the cosmic fireball that existed a fraction of a second after the big bang. Now researchers at the Relativistic Heavy Ion Collider (RHIC) at Brookhaven National Laboratory in Upton, New York, have, almost certainly, finally recreated the moments after creation. By colliding nuclei together at enormous speeds, RHIC experimenters were able to break down the structure of nuclear matter. This resulted, most experts agree, in the formation of a long-sought-after plasma that is believed to be the primal stuff of the cosmos, the state of matter at the beginning of time. It turns out, though, that the nature of matter is inextricably tied to the vacuum in which it resides. And the RHIC experiments have thrown up some surprises. They seem to show that the vacuum is a richer and more complicated place than was previously imagined. They suggest the boundary between something and nothing is more blurred than experts had predicted. The stuff made at RHIC is a plasma consisting of quarks and gluons, the most basic building blocks of everything we see around us. Quarks combine in threes to form the protons and neutrons that comprise the nucleus of every atom. But while we can observe a single proton or neutron, we cannot observe a single quark. Quarks are perpetually confined to group living. In fact, the harder you try to pull quarks apart, the stronger the force between them becomes. This is part of the theory of quantum chromodynamics (QCD), which describes how the force between the quarks is carried by the massless gluons.

In QCD, it is the vacuum that imprisons the quarks. While it may sound like a barren place, the vacuum of QCD is a complex, dynamic arena. It writhes with virtual particles that appear in pairs, then annihilate and disappear again. It is haunted by strange creatures of various kinds, too, topologically complex knots and twists that are relatives of wormholes, places where space turns in on itself and seems treacherous. These knots and twists carve out paths for the gluons to travel along, thereby keeping the quarks together. These strange ideas have credence because of the success of QCD in predicting the reactions of fundamental particles. The only way to unglue quarks is to “melt” the vacuum between them. But the vacuum doesn’t give in easily. To raze its jagged terrain requires enormous amounts of concentrated energy, found only in powerful nuclear collisions, or the fireball at the earliest moments of time.

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Many exploration destinations in our solar system are frigid and require hardware that can withstand the extreme cold. During NASA ’s Artemis missions, temperatures at the Moon’s South Pole will drop drastically during the lunar night. Farther into the solar system, on Jupiter ’s moon Europa, temperatures never rise above −260 degrees Fahrenheit (−162 degrees Celsius) at the equator.

One NASA project is developing special gears that can withstand the extreme temperatures experienced during missions to the Moon and beyond. Typically, in extremely low temperatures, gears – and the housing in which they’re encased, called a gearbox – are heated. After heating, a lubricant helps the gears function correctly and prevents the steel alloys from becoming brittle and, eventually, breaking. NASA’s Bulk Metallic Glass Gears (BMGG) project team is creating material made of “metallic glass” for gearboxes that can function in and survive extreme cold environments without heating, which requires energy. Operations in cold and dim or dark environments are currently limited due to the amount of available power on a rover or lander.

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