Lifeboat Foundation

This is a good one pass it on

This study aimed to explore whether the therapeutic effects of EPO rely on the suppression of the NLRP3 inflammasome and the specific mechanisms in an LPS-induced ALI mouse model. ALI was induced in C57BL/6 mice by intraperitoneal (i.p.) injection of LPS (15 mg/kg). EPO was administered intraperitoneally at 5 U/g after LPS challenge. The mice were sacrificed 8 h later. Our findings indicated that application of EPO markedly diminished LPS-induced lung injury by restoring histopathological changes, lessened lung wet/dry (W/D) ratio, protein concentrations in bronchoalveolar lavage fluid (BALF) and myeloperoxidase (MPO) levels. Meanwhile, EPO evidently decreased interleukin-1β (IL-1β) and interleukin-18 (IL-18) secretion, the expression of NLRP3 inflammasome components including pro-IL-1β, NLRP3, and cleaved caspase-1 as well as phosphorylation of nuclear factor-κB (NF-κB) p65, which may be associated with activation of EPO receptor (EPOR), phosphorylation of Janus-tyrosine kinase 2 (JAK2) and signal transducer and activator of transcription 3 (STAT3)

Taken together, this study indicates that EPO can effectively attenuate LPS-induced lung injury in mice by suppressing the NLRP3 inflammasome, which is dependent upon activation of EPOR/JAK2/STAT3 signaling and inhibition of the NF-κB pathway.

Continue reading “Suppression of NLRP3 Inflammasome” »

Even before the coronavirus, air pollution killed seven million people a year. Will today’s cleaner air inspire us to do better?

Mmm, 👍

Reykjanes peninsula’s last active period started in 10th century and lasted 300 years.

Kate Ravilious

Continue reading “Awakening volcanic region in Iceland ‘could cause disruption for centuries’” »

Germany has broken another renewable energy record but officials say there’s still room for improvement. The German Renewable Energy Federation (BEE) reported Sunday that the combined share of renewable energy in the electricity, transport and heating sectors was 15.2 percent in the first half of 2017, up from 14.8 percent during the same period last year.

For the electricity sector alone, renewables supplied a record 35 percent of the country’s power in the first six months of 2017, about a 2 percent increase from 2016’s numbers. To compare, renewables accounted for only 15 percent of the United States’ total electricity generation in 2016.

Despite the new benchmark, BEE acting managing director Harald Uphoff told DW that Germany’s transition to clean energy across all sectors is not happening fast enough. The BEE report showed that renewables provided only 5.1 percent of energy consumed in the transport sector and 13.6 percent in heating.

TSUNAMI WARNING NEAR JAPAN, PLEASE TAG YOUR JAPANESE FRIEND O 👍👀

The Philippine Sea plate is bordered by the larger Pacific and Eurasia plates and the smaller Sunda plate. The Philippine Sea plate is unusual in that its borders are nearly all zones of plate convergence. The Pacific plate is subducted into the mantle, south of Japan, beneath the Izu-Bonin and Mariana island arcs, which extend more than 3,000 km along the eastern margin of the Philippine Sea plate. This subduction zone is characterized by rapid plate convergence and high-level seismicity extending to depths of over 600 km. In spite of this extensive zone of plate convergence, the plate interface has been associated with few great (M8.0) ‘megathrust’ earthquakes. This low seismic energy release is thought to result from weak coupling along the plate interface (Scholz and Campos, 1995). These convergent plate margins are also associated with unusual zones of back-arc extension (along with resulting seismic activity) that decouple the volcanic island arcs from the remainder of the Philippine Sea Plate (Karig et al., 1978; Klaus et al., 1992).

South of the Mariana arc, the Pacific plate is subducted beneath the Yap Islands along the Yap trench. The long zone of Pacific plate subduction at the eastern margin of the Philippine Sea Plate is responsible for the generation of the deep Izu-Bonin, Mariana, and Yap trenches as well as parallel chains of islands and volcanoes, typical of circum-pacific island arcs. Similarly, the northwestern margin of the Philippine Sea plate is subducting beneath the Eurasia plate along a convergent zone, extending from southern Honshu to the northeastern coast of Taiwan, manifested by the Ryukyu Islands and the Nansei-Shoto (Ryukyu) trench. The Ryukyu Subduction Zone is associated with a similar zone of back-arc extension, the Okinawa Trough. At Taiwan, the plate boundary is characterized by a zone of arc-continent collision, whereby the northern end of the Luzon island arc is colliding with the buoyant crust of the Eurasia continental margin offshore China.

Continue reading “Chichi-shima, Japan” »

Researchers find a simple way to make analogue dust samples could shed light on early solar system history.

I rarely use the words transformative or breakthrough for neuroscience findings. The brain is complex, noisy, chaotic, and often unpredictable. One intriguing result under one condition may soon fail for a majority of others. What’s more, paradigm-shifting research trends often require revolutionary tools. When we’re lucky, those come once a decade.

But I can unabashedly say that the 2010s saw a boom in neuroscience breakthroughs that transformed the field and will resonate long into the upcoming decade.

In 2010, the idea that we’d be able to read minds, help paralyzed people walk again, incept memories, or have multi-layered brain atlases was near incomprehensible. Few predicted that deep learning, an AI model loosely inspired by neural processing in the brain, would gain prominence and feed back into decoding the brain. Around 2011, I asked a now-prominent AI researcher if we could automatically detect dying neurons in a microscope image using deep neural nets; we couldn’t get it to work. Today, AI is readily helping read, write, and map the brain.

Graphene hematene batteries eternal sea power.

What’s better than an underwater drone? An underwater drone that can remain at sea forever, or at least for long periods.

By Michael Peck

The ESA probe BepiColombo flew past Earth on the way to Mercury. The probe launched in 2018 and made the last visit of our home before continuing onward to the final destination. The spacecraft needs to shed velocity to arrive at Mercury in 2025 at a velocity to enter orbit. The spacecraft will make multiple additional planetary flybys of Venus and Mercury to slow down to enter orbit.

In space travel, mission planners need to balance mission resources. The amount of fuel required to either speed up or slow down a spacecraft greatly impacts the cost of the mission. Using a longer flight path can reduce the propellent requirements for a mission but the mission will take longer. Gravity assists can, therefore, allow a spacecraft to be launched on a cheaper, less powerful rocket.

Gravity assist flyby?

A Gravity assist flyby has other names including a gravitational slingshot, gravity assist maneuver, or swing-by. Gravity assistance maneuvers increase or decrease its speed or redirect the orbital path. The spacecraft slingshots around another object with a gravitational field and transfers some of the energy during that slingshot. In the case of BepiColombo, the spacecraft needs to slow down to be captured by Mercury…