Lifeboat Foundation

As part of the “Sonic Succulents” exhibit at the Brooklyn Botanic Garden, visitors are encouraged to touch plants and listen to what that contact sounds like. Dana Cronin/NPR hide caption.

In normal vision, light falls on the retinas inside the eyes, and is immediately transduced into electrochemical signals before being uploaded to the brain through the optic nerves. So you do not see light itself, but the brain’s interpretation of electrochemical signals in the visual parts of the brain. It follows that, if your eyes do not work, but your brain is stimulated just so, your visual neurons will activate (and you will be able to see) just the same as if your eyes were in perfect condition.

Sounds easy, but can we do that? Building on decades of research in visual neuroscience, my lab, in collaboration with Susana Martinez-Conde’s, has now conducted some of the studies that validate this idea, completing some of the most important preliminary steps towards a new kind of visual prosthetic.

Francis Collins, the Director of the National Institutes of Health, has just posted a blog that highlights our approach. He took notice of our work when we first presented it at this year’s meeting for the Principal Investigators of the BRAIN Initiative—the NIH led government funding initiative meant to spur research along on topics like brain implants. The BRAIN Initiative funds several agencies including the NIH, including the National Science Foundation, who kindly funded the grant driving our research thus far.

SAN ANTONIO — Sleep-disordered breathing (SDB), and the disruption in nightly sleep it causes, speeds up the aging process, according to preliminary research.

SDB is a common disorder that results in oxidative stress and inflammation and is associated with several age-related health disorders. However, it hasn’t been well studied with respect to epigenetic aging.

“To our knowledge, this study is the first empirical study that has linked sleep-disordered breathing with epigenetic age acceleration,” Xiaoyu Li, ScD, of Brigham and Women’s Hospital and Harvard Medical School in Boston, Massachusetts, told Medscape Medical News.

Is an American biochemist and cell biologist. She is a professor of biogerontology at the Buck Institute for Research on Aging. She is also a member of the SENS Research Foundation Advisory Board and an adviser at the Lifeboat Foundation. She is co-editor in chief of the Aging Journal, together with Mikhail Blagosklonny and David Sinclair, and founder of the pharmaceutical company Unity Biotechnology. She is listed in Who’s Who in Gerontology.

She is widely known for her research on how senescent cells influence aging and cancer — in particular the senescence-associated secretory phenotype (SASP).

Continue reading “Judith Campisi — Senolytics for Healthy Aging” »

Movies featuring heroes with superpowers, such as flight, X-ray vision or extraordinary strength, are all the rage. But while these popular characters are mere flights of fancy, scientists have used nanoparticles to confer a real superpower on ordinary mice: the ability to see near-infrared light. Today, scientists report progress in making versions of these nanoparticles that could someday give built-in night vision to humans.

The researchers will present their results at the American Chemical Society (ACS) Fall 2019 National Meeting & Exposition.

Continue reading “Nanoparticles could someday give humans built-in night vision” »

Exceptional longevity: the hunt for associated factors has concentrated on #genomics and biomarkers. What has been missed? Optimism. And it’s dose-dependent.

Researchers from Boston University School of Medicine (BUSM), National Center for PTSD at VA Boston Healthcare System and Harvard T.H. Chan School of Public Health, have found that individuals with greater optimism are more likely to live longer and to achieve “exceptional longevity,” that is, living to age 85 or older.

Optimism refers to a general expectation that good things will happen, or believing that the future will be favorable because we can control important outcomes. Whereas research has identified many risk factors that increase the likelihood of diseases and premature death, much less is known about positive psychosocial factors that can promote healthy aging.

Continue reading “New evidence that optimists live longer” »

An international group of scientists studied the effects of 17 different lifespan-extending interventions on gene activity in mice and discovered genetic biomarkers of longevity. The results of their study were published in the journal Cell Metabolism.

Nowadays, dozens of interventions are known that extend the lifespan of various living organisms ranging from yeast to mammals. They include chemical compounds (e.g. rapamycin), genetic interventions (e.g. mutations associated with disruption of growth hormone synthesis), and diets (e.g. caloric restriction). Some targets of these interventions have been discovered. However, there is still no clear understanding of the systemic molecular mechanisms leading to lifespan extension.

A group of scientists from Skoltech, Moscow State University and Harvard University decided to fill this gap and identify crucial molecular processes associated with longevity. To do so, they looked at the effects of various lifespan-extending interventions on the activity of genes in a mouse, a commonly used model organism closely related to humans.

I am going home :3.

Everybody wants a wormhole. I mean, who wants to bother traveling the long-and-slow routes throughout the universe, taking tens of thousands of years just to reach yet another boring star? Not when you can pop into the nearest wormhole opening, take a short stroll, and end up in some exotic far-flung corner of the universe.

There’s a small technical difficulty, though: Wormholes, which are bends in space-time so extreme that a shortcut tunnel forms, are catastrophically unstable. As in, as soon as you send a single photon down the hole, it collapses faster than the speed of light.

A gene called Lipocalin 2 is a major culprit in triple-negative breast cancer, an aggressive form of the disease for which there are few effective, targeted treatments. A team of researchers at Boston Children’s Hospital has developed an innovative way to knock out the gene using the editing system CRISPR and has shown its potential for treating triple-negative breast tumors in mice.

But to make CRISPR work in breast tumors, the researchers had to figure out a way to deliver the technology into breast cancer cells without using a virus or something else that might cause off-target side effects. So they encapsulated it in nanoparticles and targeted it at ICAM-1, a molecule expressed on breast cancer cells.

The encapsulated CRISPR system knocked out Lipocalin 2 with 81% efficiency in tumor samples, and when injected into mouse models of triple-negative breast cancer, it slowed tumor growth by 77%. The researchers reported the results in the journal Proceedings of the National Academy of Sciences.