Lifeboat Foundation

Drug development is an extremely arduous and costly process, and failure rates in clinical trials that test new drugs for their safety and efficacy in humans remain very high. According to current estimates, only 13.8% of all tested drugs demonstrate ultimate clinical success and obtain approval by the Food and Drug Administration (FDA). There are also increasing ethical concerns relating to the use of animal studies. As a result, there has been a world-wide search to find replacements for animal models.

To help address this bottleneck in drug development, Donald Ingber, M.D., Ph.D., and his team at Harvard’s Wyss Institute for Biologically Inspired Engineering, developed the first human “Organ-on-a-Chip” (Organ Chip) model of the lung that recapitulates human organ level physiology and pathophysiology with high fidelity, which was reported in Science in 2010. Organ Chips are microfluidic culture devices composed of a clear flexible polymer the size of a computer memory stick, which contains two parallel hollow channels that are separated by a porous membrane. Organ-specific cells are cultured on one side of the membrane in one of the channels, and vascular endothelial cells recapitulating a blood vessel line the other, while each channel is independently perfused with cell type-specific medium.

For those of you who are unaware of why David Sinclair is viewed with ambivalence. The headline seems complimentary, but the details paint a more complex picture that implies one shouldn’t take what Sinclair says and writes without a grain of salt.

Not yet­—but Harvard Medical School professor David Sinclair sure is getting rich, famous, and having a blast while trying.

Bias and the prospect of societal harm increasingly plague artificial-intelligence research — but it’s not clear who should be on the lookout for these problems.

Lasers and microwaves used to study crystal spinning at 200,000 rpm.

Zero to 658 in 50 seconds without emissions.

The Bloodhound LSR team has announced plans to challenge for the land speed record using a zero-emissions rocket as part of the next phase of its programme, following successful high-speed tests in South Africa last November.

Continue reading “Bloodhound to blast its way into record books with zero-emissions rocket” »

“We’re doing a lot better than people think.”–Jerome Glenn “Change is the process by which the future invades our life, and it is important to look at it closely.̶…

Public-safety drone consultancy Skyfire Consulting has announced a partnership with UAV company Doosan Mobility Innovation and hydrogen-fuel service provider ReadyH2 to tackle a pipeline-inspection project for an unnamed American company.

Doosan will deploy a hydrogen-powered octocopter. The drone sports a hydrogen-powered generator fueling two hours of flight time per mission over nearly 50 miles.

Continue reading “Hydrogen-fueled Drones Will Inspect U.S. Gas Pipeline” »

I hope AI can help reducing the risk.

It would have worked whether Chinese officials were transparent about the outbreak or not.

What defines the last decade’s hard science-fiction is a tendency to use process-oriented survival dramas to gain a personal understanding of the role of scientific inquiry and the big picture questions it poses.

From The Martian to Interstellar to Gravity, the 2010s was a comeback era.