Lifeboat Foundation

Circa 2015

Natural killer (NK) cells were discovered 40 years ago, by their ability to recognize and kill tumor cells without the requirement of prior antigen exposure. Since then, NK cells have been seen as promising agents for cell-based cancer therapies. However, NK cells represent only a minor fraction of the human lymphocyte population. Their skewed phenotype and impaired functionality during cancer progression necessitates the development of clinical protocols to activate and expand to high numbers ex vivo to be able to infuse sufficient numbers of functional NK cells to the cancer patients. Initial NK cell-based clinical trials suggested that NK cell-infusion is safe and feasible with almost no NK cell-related toxicity, including graft-versus-host disease. Complete remission and increased disease-free survival is shown in a small number of patients with hematological malignances. Furthermore, successful adoptive NK cell-based therapies from haploidentical donors have been demonstrated. Disappointingly, only limited anti-tumor effects have been demonstrated following NK cell infusion in patients with solid tumors. While NK cells have great potential in targeting tumor cells, the efficiency of NK cell functions in the tumor microenvironment is yet unclear. The failure of immune surveillance may in part be due to sustained immunological pressure on tumor cells resulting in the development of tumor escape variants that are invisible to the immune system. Alternatively, this could be due to the complex network of immune-suppressive compartments in the tumor microenvironment, including myeloid-derived suppressor cells, tumor-associated macrophages, and regulatory T cells. Although the negative effect of the tumor microenvironment on NK cells can be transiently reverted by ex vivo expansion and long-term activation, the aforementioned NK cell/tumor microenvironment interactions upon reinfusion are not fully elucidated. Within this context, genetic modification of NK cells may provide new possibilities for developing effective cancer immunotherapies by improving NK cell responses and making them less susceptible to the tumor microenvironment. Within this review, we will discuss clinical trials using NK cells with a specific reflection on novel potential strategies, such as genetic modification of NK cells and complementary therapies aimed at improving the clinical outcome of NK cell-based immune therapies.

Keywords: natural killer cells, adoptive cell therapy, immunotherapy, cancer, clinical trials, expansion, tumor microenvironment, genetic modifications.

Continue reading “Natural Killer Cell-Based Therapies Targeting Cancer: Possible Strategies to Gain and Sustain Anti-Tumor Activity” »

Circa 2015

Fusion power can seem a bit like the last bus at night; it’s always coming, but never arrives. MIT is working to change that with a new compact tokamak fusion reactor design based on the latest commercially available magnetic superconductor technology. The ARC (affordable, robust, compact) reactor design promises smaller, cheaper reactors that could make fusion power practical within 10 years.

A commercially viable fusion reactor has been the Holy Grail of engineering since the 1950s, with the potential to turn almost all other major electricity sources into an historical footnote overnight. If perfected, it would essentially be an inexhaustible source of power, impacting on almost every aspect of life, from the environment to global politics. The trick is making it practical.

Continue reading “ARC reactor design uses superconducting magnets to draw fusion power closer” »

A new study sheds light on how the brain categorizes ambiguous visual images as faces or hands.

Black holes, regions in space with such an intense gravitational field that no matter or radiation can escape from them, are among the most mysterious and fascinating cosmological phenomena. Over the past five years or so, astrophysicists collected the first observations of the strong gravitational forces around black holes.

The LIGO-Virgo collaboration was able to detect gravitational waves around these celestial objects using some of the most advanced gravitational-wave detectors in the world. Meanwhile, the Event Horizon Telescope research group captured the very first image of a black hole shadow.

While both these observations are highly promising and captivating, neither of them is likely to unveil the event horizon, the boundary defining the specific region in space around a black hole from which nothing can escape. Nonetheless, they should contain a signature pointing to a neighboring region just outside of the event horizon, wherein light is bent so strongly that its path closes over itself and forms circular orbits known as light rings.

Who has heard of mitochondrial medicine?

“We know that increased rates of mtDNA mutation cause premature aging,” said Bruce Hay, Professor of biology and biological engineering at the California Institute of Technology. “This, coupled with the fact that mutant mtDNA accumulates in key tissues such as neurons and muscle that lose function as we age, suggests that if we could reduce the amount of mutant mtDNA, we could slow or reverse important aspects of aging.”

This brings us to the second major development relevant to mitochondria in disease — that genetic technology is now at a point where the targeted removal of the problem mitochondrial genes can become the basis for clinical intervention. This is the implication of research that Hay and colleagues both at Caltech and the University of California at Los Angeles described in a paper published in the journal Nature Communications.

Continue reading “Battling Parkinson’s disease” »

Unlike Earth, Mars doesn’t have a global magnetic field to protect it from the rigours of space weather – but it does have spots of local, induced magnetism.

Now, researchers have been able to create an incredible, detailed map of the electric currents that are responsible for shaping these magnetic fields.

It gives scientists a much greater understanding of how Mars might have lost much of its atmosphere over the course of billions of years, as well as how interactions between the solar winds and Mars’ magnetosphere are playing out today.

Sadly, we have found our way to this place.

I am ashamed of our Political & Social Leaders. What we have allowed over the past few days is a group of #AntifaThugs and #AgentProvocateurs to run amuck in our fine country. We have allowed this scum to burn and rob and murder all for the fake belief of Social Justice.

George Floyd was murdered in the streets. He was murdered by a bad cop who is going to face justice for his actions, for good or for ill. The other officers who were on the scene who have not been arrested most likely will be. If they are not, then they are going to live with the fact that they watched a man die, who they should have protected.

Ladies Monday with ReallyGraceful.

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