Lifeboat Foundation

Heart regeneration, a relatively new field of biology, is one of the most active and controversial areas of biomedical research. The potential impact of successful human heart regeneration therapeutics cannot be overstated, given the magnitude and prognosis of heart failure. However, the regenerative process is highly complex, and premature claims of successful heart regeneration have both fueled interest and created controversy. The field as a whole is now in the process of course correction, and a clearer picture is beginning to emerge. Despite the challenges, fundamental principles in developmental biology have provided a framework for hypothesis-driven approaches toward the ultimate goal of adult heart regeneration and repair. In this review, we discuss the current state of the field and outline the potential paths forward toward regenerating the human myocardium.

Cardiovascular diseases have long been the leading cause of death in both industrialized and developing countries. This broad term includes mortality from both vascular and myocardial disease and has been heavily driven by mortality from acute vascular events such as myocardial infarction. This epidemic of vascular death has led to important advances in both basic and clinical research, with significant results. The rates of both myocardial infarction and associated fatalities have been steadily declining (Yeh et al., 2010) thanks to advances in risk-factor management, as well as advanced therapies for coronary revascularization. Unfortunately, myocardial damage from non-lethal cardiac events has contributed to the increased prevalence of cardiomyopathy (Khera et al., 2017; Yeh et al., 2010).

Cardiomyopathy, or weakening of the heart muscle, is a devastating progressive disease with a prognosis worse than that of many malignancies (Mosterd and Hoes, 2007). Decades of advances in understanding the myocardial response to injury have led to the development of safe and effective drugs that slow the progression of cardiomyopathy and even restore function in some reversible cases where there is no significant myocyte loss (Yancy et al., 2017). These drugs mainly target sympathetic activation, afterload, and fibrosis pathways, which are responsible for the progressive nature of the disease after an initial insult. However, to date we have no answer to the disease’s central underlying basis, which is cardiomyocyte loss. The notion that it might be possible to rebuild the cardiac muscle, or to regenerate the myocardium, after injury has sparked significant interest over the past two decades, and it has created a battleground for competing theories and ideas.

Tesla is going to work with spaceships too. Enhanced partnership with SpaceX.

This is revealed by a new job position, for future designers who will range from electric cars to spaceships for Mars.

A couple of days ago SpaceX tested a prototype of the future Starship, the spacecraft that will be flying to the Moon and Mars. It was a rather raw reproduction, just slightly reminiscent of the style used in the digital rendering presentation. Today we discover that, as demonstrated by a new job place, Tesla’s may be called into the final design.

Continue reading “Tesla is going to work with space ships too. Enhanced partnership with SpaceX” »

The Ogba Educational Clinic is pioneering ethics in Digital technology in Africa.

The federal government’s cyber plan is long on action points but short on any organising principles. This is worrying.

Saint Kitts and Nevis became the 44th country to ratify the UN Treaty on the Prohibition of Nuclear Weapons on Sunday, the 75th anniversary of the US atomic bombing on the Japanese city of Nagasaki. Six more ratifications are now needed to bring the treaty into force.

The Caribbean nation’s foreign minister, Mark Brantley, said in a statement that the bombing of Nagasaki was the apogee of human cruelty and inhumanity.

He said his country, as a small nation committed to global peace, can see no useful purpose for nuclear armaments. He called on all nations to work towards peace and mutual respect for all mankind.

We came across a piece today over at Motorbike Writer about Yamaha preparing a water-powered motorcycle, and while a quick Google revealed this to be nothing more than a Yamaha-sponsored thesis project from 2016, the idea itself is fascinating enough to follow down the rabbit hole.

Water-powered or water-engined are the wrong terms for this. What’s being proposed is a system that replaces the chain, belt or shaft drive to the rear wheel with a hydraulic system that uses water pressure to spin the back wheel. So a fluid drive is probably the better way to put it. Designer Maxime Lefebvre admits as much in the “engine breakdown” slide, saying “to be effective, it needs a water pump.”

That water pump would be the engine. But how realistic is it to think about a water drive system? And what would be the pros and cos of such a thing? Perhaps we can look to two previous New Atlas stories for answers.

Seres Therapeutics soared as much as 608% on Monday after the company announced positive phase 3 trial data for its drug SER-109 was de…

We take a trip down Lifespan.io’s Rejuvenation Roadmap – and it’s a journey towards Longevity progress.

Kitasato University Hospital researchers in Japan found that patients with smaller eye pupils were twice as likely to die from heart failure.

Meanwhile, 47 per cent of those with small pupils were readmitted to hospital, compared with just 28 per cent of those with large pupils.

Study author Dr Kohei Nozaki, of Kitasato University Hospital in Japan, said: ‘Our results suggest that pupil area is a novel way to identify heart patients at elevated risk of death or hospital readmission.

Could there really be a magic pill for immortality?