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Apr 25, 2020

Sequential LASER ART and CRISPR Treatments Eliminate HIV-1 in a Subset of Infected Humanized Mice

Posted by in categories: biotech/medical, neuroscience

Does anyone remember this from July 2019? đŸ€”.


Elimination of HIV-1 requires clearance and removal of integrated proviral DNA from infected cells and tissues. Here, sequential long-acting slow-effective release antiviral therapy (LASER ART) and CRISPR-Cas9 demonstrate viral clearance in latent infectious reservoirs in HIV-1 infected humanized mice. HIV-1 subgenomic DNA fragments, spanning the long terminal repeats and the Gag gene, are excised in vivo, resulting in elimination of integrated proviral DNA; virus is not detected in blood, lymphoid tissue, bone marrow and brain by nested and digital-droplet PCR as well as RNAscope tests. No CRISPR-Cas9 mediated off-target effects are detected. Adoptive transfer of human immunocytes from dual treated, virus-free animals to uninfected humanized mice fails to produce infectious progeny virus. In contrast, HIV-1 is readily detected following sole LASER ART or CRISPR-Cas9 treatment. These data provide proof-of-concept that permanent viral elimination is possible.

Apr 24, 2020

Here are the so far identified genomic variants of COVID, we are up for quite a powerful enemy!

Posted by in categories: biotech/medical, life extension

The good side is that most people who are generally healthy won’t get ill from it! smile So let’s cure aging to avoid having these pandemies upcoming in the future!

Apr 24, 2020

A paralyzed woman flew an F-35 fighter jet in a simulator — using only her mind

Posted by in categories: biotech/medical, cyborgs, military

Circa 2015


A 55-year old Pittsburgh woman has successfully controlled a prosthetic arm — and now a Joint Strike Fighter aircraft — with just her thoughts.

Apr 24, 2020

What aircraft does the US Air Force need to beat China and Russia? This new study has an answer

Posted by in categories: military, robotics/AI

The future looks stealthy and unmanned.

Apr 24, 2020

The manufacturer of Lysol issues a warning against the use of its disinfectant products for internal use after Donald Trump’s comments on a possible treatment for patients with coronavirus

Posted by in categories: biotech/medical, health

Have a good day group 😅.


On Thursday, Donald Trump raised a few eyebrows as he spoke at the White House daily briefing on the coronavirus. Like us previously He reportedly suggested using UV lights or injecting disinfectants into a person affected by the virus.

Oddly enough, Trump’s suggestion not only sparked a conversation, as many people ignored him, but also prompted RB, the makers of Lysol and Dettol, to release a statement to assure everyone that their products are NOT for internal use, despite Trump’s suggestion.

Continue reading “The manufacturer of Lysol issues a warning against the use of its disinfectant products for internal use after Donald Trump’s comments on a possible treatment for patients with coronavirus” »

Apr 24, 2020

Clinical Characteristics, Comorbidities, and Outcomes Among Patients With COVID-19 Hospitalized in the NYC Area

Posted by in categories: biotech/medical, health

This case series describes clinical characteristics, health services use, and outcomes of patients with confirmed coronavirus disease 2019 (COVID-19) cared for at 12 hospitals of a single health system in the New York City (NYC) area.

Apr 24, 2020

UV Light That Is Safe for Humans but Bad for Bacteria and Viruses

Posted by in categories: biotech/medical, health

In the constant battle against the spread of infectious diseases, scientists are continually on the hunt for new weapons that specifically target pathogenic microbes. Now, investigators from the Center for Radiological Research at Columbia University Irving Medical Center (CUIMC) believe they may have found a new, low-cost solution to eradicating airborne viruses in indoor public spaces. The research team found that continuous low doses of far ultraviolet C (far-UVC) light can kill airborne flu viruses without harming human tissues. The findings from the new study—published today in Scientific Reports in an article entitled “Far-UVC Light: A New Tool to Control the Spread of Airborne-Mediated Microbial Diseases”—suggests that use of overhead far-UVC light in hospitals, doctors’ offices, schools, airports, airplanes, and other public spaces could provide a powerful check on seasonal influenza epidemics, as well as influenza pandemics.

Scientists have known for decades that broad-spectrum UVC light, which has a wavelength of between 200 to 400 nanometers (nm), is highly effective at killing bacteria and viruses by destroying the molecular bonds that hold their DNA together. This conventional UV light is routinely used to decontaminate surgical equipment.

“Unfortunately, conventional germicidal UV light is also a human health hazard and can lead to skin cancer and cataracts, which prevents its use in public spaces,” explained senior study investigator David Brenner, Ph.D., director of the Center for Radiological Research and professor at CUIMC.

Apr 24, 2020

Coronavirus Diagnoses In Staff Drop By Half After Boston Hospital Requires Masks For All

Posted by in category: biotech/medical

New infections diagnosed in Brigham and Women’s employees dropped from 12 or 14 a day to more like eight once they all had to wear masks, and to about six once patients had to wear masks as well.

Apr 24, 2020

Over 20 tornadoes hammered the South on Wednesday, more expected Thursday

Posted by in category: climatology

:oooo.


SOUTHERN UNITED STATES — Over 20 tornadoes touched down in the southern United States Wednesday, April 22 and more are expected Thursday, April 23. At one point, there were four distinct supercells on radar producing a tornado in Oklahoma.

Continue reading “Over 20 tornadoes hammered the South on Wednesday, more expected Thursday” »

Apr 24, 2020

America’s bomber force is facing a crisis

Posted by in categories: government, military, policy, security

The path forward begins with admitting the nation has a bomber shortfall. Retiring more aircraft exacerbates the problem. Nor is this just an Air Force problem. Bombers are national assets essential to our security strategy and must be prioritized accordingly. If other services have excess funds to invest in ideas like a 1,000-mile-range cannon when thousands of strike aircraft, various munitions and remotely piloted aircraft can fill the exact same mission requirements, it is time for a roles and missions review to direct funding toward the most effective, efficient options. Bombers would compete well in such an assessment. Ultimately, the solution demands doubling down on the B-21 program.

There comes a point where you cannot do more with less. Given the importance of bombers to the nation, rebuilding the bomber force is not an option — it is an imperative.

Retired U.S. Air Force Maj. Gen. Larry Stutzriem served as a fighter pilot and held various command positions. He concluded his service as the director of plans, policy and strategy at North American Aerospace Defense Command and U.S. Northern Command. He is currently the director of studies at the Mitchell Institute for Aerospace Studies, where Douglas Birkey is the executive director. Birkey researches issues relating to the future of aerospace and national security, and he previously served as the Air Force Association’s director of government relations.