The man on the trail went by “Mostly Harmless.” He was friendly and said he worked in tech. After he died in his tent, no one could figure out who he was.
The p53 gene like the Rb gene, is a tumor suppressor gene, i.e., its activity stops the formation of tumors. If a person inherits only one functional copy of the p53 gene from their parents, they are predisposed to cancer and usually develop several independent tumors in a variety of tissues in early adulthood. This condition is rare, and is known as Li-Fraumeni syndrome. However, mutations in p53 are found in most tumor types, and so contribute to the complex network of molecular events leading to tumor formation.
The p53 gene has been mapped to chromosome 17. In the cell, p53 protein binds DNA, which in turn stimulates another gene to produce a protein called p21 that interacts with a cell division-stimulating protein (cdk2). When p21 is complexed with cdk2 the cell cannot pass through to the next stage of cell division. Mutant p53 can no longer bind DNA in an effective way, and as a consequence the p21 protein is not made available to act as the ‘stop signal’ for cell division. Thus cells divide uncontrollably, and form tumors.
Help with unraveling the molecular mechanisms of cancerous growth has come from the use of mice as models for human cancer, in which powerful ‘gene knockout’ techniques can be used. The amount of information that exists on all aspects of p53 normal function and mutant expression in human cancers is now vast, reflecting its key role in the pathogenesis of human cancers. It is clear that p53 is just one component of a network of events that culminate in tumor formation.
Scientists in collaboration have developed the world’s first metasurface laser that produces “super-chiral light”- the light with ultra-high angular momentum. Also, they have developed a nanostructured metasurface that has the most significant phase gradient ever produced and allows for high power operation in a compact design.
Researchers at MIT and the University of Waterloo have developed a high-power, portable version of a device called a quantum cascade laser, which can generate terahertz radiation outside of a laboratory setting. The laser could potentially be used in applications such as pinpointing skin cancer and detecting hidden explosives.
Until now, generation of terahertz radiation powerful enough to perform real-time imaging and fast spectral measurements required temperatures far below 200 Kelvin (−100 degrees Fahrenheit) or lower. These temperatures could only be achieved with bulky equipment that limited the technology’s use to a laboratory setting. In a paper published in Nature Photonics, MIT Distinguished Professor of Electrical Engineering and Computer Sciences Qing Hu and his colleagues report that their terahertz quantum cascade laser can function at temperatures of up to 250 K (−10 degrees Fahrenheit), meaning that only a compact portable cooler is required.
Terahertz quantum cascade lasers, tiny chip-embedded semiconductor laser devices, were first invented in 2002, but adapting them to operate far above 200 K proved to be so difficult that many people in the field speculated that there was a fundamental physical reason preventing it, Hu says.
The Genetic Code
Posted in genetics
This video explain the details of genetic code in detail.
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Yes, there’s been hype, but electrical brain stimulation is a genuine technique, and the science behind it is improving.
Poimo inflatable scooter
Posted in futurism
We all know how difficult it is to bring a scooter anywhere.
Here is an interesting solution. An infatable scooter.
This is an inflatable scooter you can put in your backpack.
Chain Delete Bike
Posted in transportation
For those who like biking.
I stilll remember all those times my bike chains got lose. Could these guys have found a solution?
This chainless bike is dubbed ‘the most aerodynamic bike ever made’.
Would you like to have your own personal emoji display on your car?
These guys seem to having fun with it.
Article from Vice.com. I guess owning a Tesla does have its own drawbacks. Tesla can disable features from your car if you didn’t pay enough money. And it seems it’s hard to repair if you get into an accident, due to Tesla’s tight ownership. Insurance companies may quickly declare these Teslas as total losses.
This is pushing some people to jailbreak their cars to return these features. Especially those that are already declared as total losses. (So voiding the warranty really doesn’t mean much to them)
Interesting. bigsmile
Tesla is getting more aggressive in revoking paid software features on used cars, raising the stakes in a battle over what used Teslas can do that has raged for years.