Lifeboat Foundation

Within a mere eight years, CRISPR-Cas9 has become the go-to genome editor for both basic research and gene therapy. But CRISPR-Cas9 also has spawned other potentially powerful DNA manipulation tools that could help fix genetic mutations responsible for hereditary diseases.

Researchers at the University of California, Berkeley, have now obtained the first 3D structure of one of the most promising of these tools: base editors, which bind to DNA and, instead of cutting, precisely replace one nucleotide with another.

First created four years ago, base editors are already being used in attempts to correct single-nucleotide mutations in the human genome. Base editors now available could address about 60% of all known genetic diseases—potentially more than 15,000 inherited disorders—caused by a mutation in only one nucleotide.

A new AI algorithm developed by the University of Pittsburgh has achieved the highest accuracy to date in identifying prostate cancer, with 98% sensitivity and 97% specificity.

It’s the banking world’s version of the rich getting richer.

A record $2 trillion surge in cash hit the deposit accounts of U.S. banks since the coronavirus first struck the U.S. in January, according to FDIC data.

The wall of money flowing into banks has no precedent in history: in April alone, deposits grew by $865 billion, more than the previous record for an entire year.

Appy, France is being used to demo that electric cars work in remote areas.

The toxin can block the use of important amino acids required by the bacteria to produce essential proteins needed for survival.

An international team of researchers, led by Durham University, UK, and the Laboratory of Molecular Microbiology and Genetics/Centre Integrative Biology in Toulouse, France, are aiming to exploit this toxin to develop new anti-TB drugs.

Their findings are published in the journal Science Advances.

A radical new method of imaging that harnesses artificial intelligence to turn time into visions of 3D space could help cars, mobile devices and health monitors develop 360-degree awareness.

Photos and videos are usually produced by capturing photons—the building blocks of light—with digital sensors. For instance, digital cameras consist of millions of pixels that form images by detecting the intensity and color of the light at every point of space. 3D images can then be generated either by positioning two or more cameras around the subject to photograph it from multiple angles, or by using streams of photons to scan the scene and reconstruct it in three dimensions. Either way, an image is only built by gathering spatial information of the scene.

In a new paper published today in the journal Optica, researchers based in the U.K., Italy and the Netherlands describe an entirely new way to make animated 3D images: by capturing temporal information about photons instead of their spatial coordinates.

Protein in squid teeth could hold the solution for self-healing materials.

A way of shrinking the devices used in quantum sensing systems has been developed by researchers at the UK Quantum Technology Hub Sensors and Timing, which is led by the University of Birmingham.

Sensing devices have a huge number of industrial uses, from carrying out ground surveys to monitoring volcanoes. Scientists working on ways to improve the capabilities of these sensors are now using quantum technologies, based on cold atoms, to improve their sensitivity.

Machines developed in laboratories using quantum technology, however, are cumbersome and difficult to transport, making current designs unsuitable for most industrial uses.

Scientists have revived 100-million-year-old microbes, giving us another glimpse at what life was like far in the past.