https://www.youtube.com/watch?v=Gz8vBoEFArA&feature=youtu.be
Catch up on all the excitement of our newest products from the October Event. iPhone 12, iPhone 12 mini, iPhone 12 Pro, iPhone 12 Pro Max, and HomePod mini. It’s all here.
“Say My Name” by Jaded.
The planned launch of a private commercial airlock to the International Space Station in November will accelerate NASA’s plan to turn the station into a hub of private industry, space agency officials said.
The commercialization plan also includes the launch of a private habitat and laboratory by 2024 and a project NASA Administrator Jim Bridenstine announced on Twitter in May in which actor Tom Cruise will film a movie in space.
The 20-year-old space station may even have a private citizen on board again for the first time in years in late 2021, according to Phil McAlister, NASA’s director of commercial spaceflight. It’s part of a plan to wean the space station off NASA’s public funding of $3 billion to $4 billion per year.
When it comes to vitamin D, most adults exhibit either frank deficiency, which results in clear clinical symptoms, or insufficiency, which often goes undetected. But how that insufficiency impacts physical health and the vulnerability of older adults to frailty as they age has been difficult to determine.
Now a University at Buffalo study of 24–28–month-old mice, the equivalent of 65-to-80-year-old adults, has found that frailty can be slowed with what might be considered “over” supplementation with vitamin D, referred to as “hypersufficiency.”
Published Sept. 30 in Nutrients, the research builds on previous work that Kenneth L. Seldeen, Ph.D., first author and research assistant professor in the Department of Medicine in the Jacobs School of Medicine and Biomedical Sciences at UB, has been conducting for more than a decade with colleague Bruce R. Troen, MD, professor of medicine and chief of the Division of Geriatrics and Palliative Medicine and director of the Center for Successful Aging, both in the Jacobs School.
Gets advanced, but some might like.
A research team from Cologne has discovered that a change in the DNA structure—more precisely in the chromatin—plays a decisive role in the recovery phase after DNA damage. The key is a double occupation by two methyl groups on the DNA packaging protein histone H3 (H3K4me2). The discovery was made by scientists under the direction of Prof. Björn Schumacher of the Cluster of Excellence for Aging Research CECAD, the Center for Molecular Medicine Cologne (CMMC), and the Institute for Genome Stability in Aging and Disease at the University of Cologne. The specific change enables genes to be reactivated and proteins to be produced after damage: The cells regain their balance and the organism recovers. The protective role of H3K4me2 was identified in experiments with the nematode Caenorhabditis elegans. The study has now been published in the journal Nature Structural & Molecular Biology.
The genome in every human cell is damaged on a daily basis, for example in the skin by UV radiation from the sun. Damage to the DNA causes diseases such as cancer, influences development, and accelerates aging. Congenital malfunctions in DNA repair can lead to extremely accelerated aging in rare hereditary diseases. Therefore, preservation and reconstruction processes are particularly important to ensure development and to maintain tissue function. DNA, which is rolled up on packaging proteins—the histones—like on cable drums, is regulated by methyl groups. Various proteins are responsible for placing methyl groups on histones or removing them. The number of groups on the packaging proteins affects the activity of genes and thus the protein production of the cell.
My hero my love.
Last week, Tesla CEO Elon Musk made a rather interesting announcement for all-electric vehicle enthusiasts in India, when he mentioned that Tesla is planning on entering the Indian automobile market in 2021. The announcement comes after years of waiting for the Indians to get their hands on a Tesla, and it definitely has got the public buzzing with excitement. Now, Musk has also stated that Tesla will be coming up with a Booking Order Configurator for the Indian customers which will be going live in January 2021.
Circa 2018
If you’ve been a grunt, then you probably have a love-hate relationship with body armor. You love having it in a firefight — it can save your life by stopping or slowing bullets and fragments — but you hate how heavy it is — it’s often around 25 pounds for the armor and outer tactical vest (more if you add the plate inserts to stop up to 7.62mm rounds). It’s bulky — and you really can’t move as well in it. In fact, in one firefight, a medic removed his body armor to reach wounded allies, earning a Distinguished Service Cross.
Elon Musk is among the few people on Earth that are working towards changing the course of humanity’s future in a drastic way. He founded SpaceX in 2002 to make life multiplanetary –colonize Mars. Since then, SpaceX has developed some of the world’s most advanced rockets and spacecraft. Throughout the years Musk’s bold ideas, ambitious goals, and ability to lead teams to achieve greatness has earned him a place in history. Hollywood actor Channing Tatum seems to be inspired by Musk’s space venture that he is now planning to produce an HBO drama television series about Musk and his journey at SpaceX.
According to Deadline reporters, who first reported the news, Tatum’s film production company, Free Association, will produce a six-episode scripted series. The story will be about how SpaceX started with a rocket that almost did not make it to orbit, to returning human spaceflight capabilites to the United States. “The project will be penned by Star Trek Beyond scribe Doug Jung based on Ashlee Vance’s book Elon Musk: Tesla, SpaceX, and the Quest for a Fantastic Future, first published in 2017,” Deadline reports, “Free Association’s Tatum, Reid Carolin and Peter Kiernan will executive produce with Vance and Len Amato, HBO’s former President Of HBO Films, Miniseries & Cinemax.”
A research collaboration between Kumamoto University and Nagasaki University in Japan has found that components leaking from broken muscle fibers activate “satellite” muscle stem cells. While attempting to identify the proteins that activate satellite cells, they found that metabolic enzymes, such as GAPDH, rapidly activated dormant satellite cells and accelerated muscle injury regeneration. This is a highly rational and efficient regeneration mechanism in which the damaged muscle itself activates the satellite cells that begin the regeneration process.
Skeletal muscle is made up of bundles of contracting muscle fibers and each muscle fiber is surrounded by satellite cells —muscle stem cells that can produce new muscle fibers. Thanks to the work of these satellite cells, muscle fibers can be regenerated even after being bruised or torn during intense exercise. Satellite cells also play essential roles in muscle growth during developmental stages and muscle hypertrophy during strength training. However, in refractory muscle diseases like muscular dystrophy and age-related muscular fragility (sarcopenia), the number and function of satellite cells decreases. It is therefore important to understand the regulatory mechanism of satellite cells in muscle regeneration therapy.
In mature skeletal muscle, satellite cells are usually present in a dormant state. Upon stimulation after muscle injury, satellite cells are rapidly activated and proliferate repeatedly. During the subsequent myogenesis, they differentiate and regenerate muscle fibers by fusing with existing muscle fibers or with together. Of these three steps (satellite cell activation, proliferation, and muscle differentiation), little is known about how the first step, activation, is induced.
Could make awesome computers.
Materials scientists who work with nano-sized components have developed ways of working with their vanishingly small materials. But what if you could get your components to assemble themselves into different structures without actually handling them at all?
Verner Håkonsen works with cubes so tiny that nearly 5 billion of them could fit on a pinhead.
Continue reading “5 Billion of These Super-Strong Magnetic Supercrystals Can Fit on a Pinhead” »
Telescopes have captured the rare light flash from a dying star as it was ripped apart by a supermassive black hole.
