Characterizing molecular aging features is crucial for understanding systemic and local factors contributing to the aging process. Here Costa, Chen et al. performed RNA sequencing on 13 tissues across six ages in male and female African turquoise killifish. This sex-balanced killifish aging atlas provides a comprehensive resource for studying aging dynamics across tissues in the killifish—a powerful, short-lived vertebrate model of aging.
A new study from the University of Helsinki reveals how plant mitochondria draw molecular oxygen away from chloroplasts, an interaction not previously documented. The discovery sheds new light on how plants regulate oxygen inside their tissues, with implications for understanding plant metabolism and stress acclimation. The research, led by Dr. Alexey Shapiguzov (Ph. D., Docent) from the University’s Centre of Excellence in Tree Biology on the Viikki campus, has been published in Plant Physiology.
Oxygen gas is central to plant metabolism, growth, stress acclimation and immunity. Recent research at the University of Helsinki has shown that oxygen triggers wound healing in plants. Yet, despite its importance, scientists still lack an understanding of how oxygen levels inside plant tissues are controlled.
In plant cells, oxygen dynamics are dominated by two organelles: mitochondria that consume oxygen during respiration, and chloroplasts that produce oxygen as a by-product of photosynthesis.
Kanabar SS, Pavord ID, Hinks TSC. Respir Med. 2026 Feb 26:108736. doi: 10.1016/j.rmed.2026.108736. Highlights • Asthma is a heterogeneous condition due to multiple biological processes. • Individual treatable traits are identifiable and responsive to treatment. • Extra-pulmonary traits are important to consider and address. Abstract In the era of personalised medicine, approaches to asthma assessment
Learn more about this fascinating technique which is coming to cardiovascular medicine:
Paper:
Podcast with the authors: https://bit.ly/49oxvq9
Photon-counting CT (PCCT) represents a transformative advancement in cardiac imaging, addressing key limitations of conventional CT. This review synthesises current evidence to demonstrate how PCCT’s superior spatial resolution, enhanced tissue characterisation and multienergy capabilities broaden the diagnostic potential of cardiac CT. Applications include the precise detection and quantification of coronary artery calcifications, evaluation of coronary plaque burden and composition, improved assessment of coronary stents, and comprehensive myocardial tissue characterisation and perfusion analysis. By offering high-quality spectral information and detailed tissue characterisation, PCCT provides a non-invasive alternative for assessing coronary artery disease and myocardial pathology, reducing the need for invasive coronary angiography and cardiac MRI.
This phase 2 nonrandomized clinical trial evaluated oral upadacitinib for severe immune checkpoint inhibitor–related dermatitis in patients with solid tumors.
Rash resolution to grade ≤1 was achieved in all participants within 28 days, and pruritus improvement was reported within 1 day of initiation. Upadacitinib was well tolerated, with no serious treatment-related adverse events.
The majority of patients were able to continue immune checkpoint inhibitor therapy as scheduled, indicating the potential of upadacitinib as a safe and effective option for managing severe Dermatitis induced by immunotherapy.
This nonrandomized clinical trial examines the safety and efficacy of oral upadacitinib in the treatment of patients with severe immune checkpoint inhibitor–related dermatitis.
[Alzheimer’s disease: AD] Zhang et al.: “Increased theta band power was statistically significant in AD patients, highlighting its critical role in AD pathology.”
Your browser extensions or network settings have blocked the security verification process required by www.sciencedirect.com. To resolve this, try the following steps:
Temporarily disable browser extensions:
ObjectivesWe report on a patient with a distinct clinical and neuroradiologic phenotype and a de novo variant in the FTH1 gene. MethodsThe patient was a 25-year-old woman with developmental delay and pontocerebellar hypoplasia, who after years of stable condition visited our hospital at age 20 years because of clinical deterioration. With consent from the patients’ family, we obtained clinical, imaging, and genetic data from the patient’s medical record.