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Specially packaged DNA secreted by tumor cells can trigger an immune response that inhibits the metastatic spread of the tumor to the liver, according to a study led by researchers at Weill Cornell Medicine, Memorial Sloan Kettering Cancer Center and Korea’s Yonsei University. The discovery improves the scientific understanding of cancer progression and anticancer immunity, and could yield new clinical tools for assessing and reducing metastasis risk.

In the study, reported Dec. 3 in Nature Cancer, the researchers examined cancer cells’ secretion of short stretches of DNA packaged on tiny capsules called extracellular vesicles (EVs). All cells use EVs to secrete proteins, DNA and other molecules, and tumor cells are particularly active EV secreters.

The biological functions of these EV-packaged molecules are still being explored, but in this case, the researchers discovered that in various cancer types, EV-DNA secreted by tumor cells works as a “danger” signal that activates an anti-tumor response in the liver, reducing the risk of liver metastasis.

Communities of microbes (microbiomes), particularly in soils, can be startlingly diverse, with as many as 10,000 species in just a cup of material. Scientists are working to understand how microbiomes and their members respond to their environments. These processes can profoundly shape the properties and composition of soils.

In a pair of studies published in The ISME Journal, researchers investigated how different species of microbes interact with one another and exchange resources such as vitamins. The studies focused on corrinoids, the vitamin B12 family of nutrients. Many bacteria in the environment cannot produce these chemicals.

Focusing on a single type of nutrient enables the study of microbiomes in greater detail. The two studies further synergized by focusing on the same California grassland soil, allowing the researchers to generate a framework for understanding nutrient cycling in this system.

The question as to whether morality is innate has been hotly debated in developmental psychology for decades.

An international study with LMU participation provides evidence that our moral sense is not innate.

On September 12 2024, Sam Altman, Chief Executive Officer of OpenAI, participated in a fireside chat for University of Michigans students, faculty and staff. The ChatGPT developer head spoke about the future of AI and its implications for education, as well as the challenges and opportunities presented by rapid technological advancements. Altman also shared insights into OpenAI’s new reasoning model, Strawberry, a model he describes as capable of complex reasoning and problem-solving.

“You all are going to create things that astonish us. The story of human history is that we build better tools, and then people do even more amazing stuff with them, and they themselves, you know, add their layer of scaffolding. And we’re on this steadily increasing curve of possibility.”

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High harmonic generation (HHG) is a highly non-linear phenomenon where a system (for example, an atom) absorbs many photons of a laser and emits photons of much higher energy, whose frequency is a harmonic (that is, a multiple) of the incoming laser’s frequency. Historically, the theoretical description of this process was addressed from a semi-classical perspective, which treated matter (the electrons of the atoms) quantum-mechanically, but the incoming light classically. According to this approach, the emitted photons should also behave classically.

Despite this evident theoretical mismatch, the description was sufficient to carry out most of the experiments, and there was no apparent need to change the framework. Only in the last few years has the scientific community begun to explore whether the emitted light could actually exhibit a quantum behavior, which the semi-classical theory might have overlooked. Several theoretical groups, including the Quantum Optics Theory group at ICFO, have already shown that, under a full quantum description, the HHG process emits light with quantum features.

However, experimental validation of such predictions remained elusive until, recently, a team led by the Laboratoire d’Optique Appliquée (CNRS), in collaboration with ICREA Professor at ICFO Jens Biegert and other multiple institutions (Institut für Quantenoptik—Leibniz Universität Hannover, Fraunhofer Institute for Applied Optics and Precision Engineering IOF, Friedrich-Schiller-University Jena), demonstrated the quantum optical properties of high-harmonic generation in semiconductors. The results, appearing in PRX Quantum, align with the previous theoretical predictions about HHG.

The deep neural network models that power today’s most demanding machine-learning applications have grown so large and complex that they are pushing the limits of traditional electronic computing hardware.

Photonic hardware, which can perform machine-learning computations with light, offers a faster and more energy-efficient alternative. However, there are some types of neural network computations that a photonic device can’t perform, requiring the use of off-chip electronics or other techniques that hamper speed and efficiency.

Building on a decade of research, scientists from MIT and elsewhere have developed a new photonic chip that overcomes these roadblocks. They demonstrated a fully integrated photonic processor that can perform all the key computations of a deep neural network optically on the chip.

Physicists at Loughborough University have made an exciting breakthrough in understanding how to fine-tune the behavior of electrons in quantum materials poised to drive the next generation of advanced technologies.

Quantum materials, like bilayer graphene and strontium ruthenates, exhibit remarkable properties such as superconductivity and magnetism, which could revolutionize areas like computing and energy storage.

However, these materials are not yet widely used in real-world applications due to the challenges in understanding the complex behavior of their electrons—the particles that carry electrical charge.

An optical lattice clock is a type of atomic clock that can be 100 times more accurate than cesium atomic clocks, the current standard for defining “seconds.” Its precision is equivalent to an error of approximately one second over 10 billion years. Owing to this exceptional accuracy, the optical lattice clock is considered a leading candidate for the next-generation “definition of the second.”

Professor Hidetoshi Katori from the Graduate School of Engineering at The University of Tokyo has achieved a milestone by developing the world’s first compact, robust, ultrahigh-precision optical lattice clock with a device capacity of 250L.

As part of this development, the physics package for spectroscopic measurement of atomic clock transitions, along with the laser and control system used for trapping and spectroscopy of atoms, was miniaturized. This innovation reduced the device volume from the traditional 920 to 250 L, approximately one-quarter of the previous size.

Tesla hasn’t unveiled its next generation human robot in the form of the app named GEN-3 Teslabot, bringing with it significant advancements in the field of humanoid robotics, merging state-of-the-art engineering with a design inspired by human anatomy. This next-generation robot demonstrates exceptional dexterity and precision, setting a new benchmark for what humanoid robots can accomplish. From catching a tennis ball mid-air to envisioning tasks like threading a needle, the Teslabot is poised to reshape how robots interact with and adapt to the world around them.

Wouldn’t it be great if robots didn’t just assemble cars or vacuum your living room but perform tasks requiring the finesse of human hands—threading a needle, playing a piano, or even catching a tennis ball mid-air. It sounds like science fiction, doesn’t it? Yet, Tesla’s latest innovation, the GEN-3 Teslabot, is bringing us closer to that reality. With its human-inspired design and new engineering, this robot is redefining what we thought machines could do.

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