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Rethinking Inflammation: Is Everything We Know About Aging and Disease Wrong?

The environment strongly influences health outcomes, especially in industrialized societies. A new study from the Columbia University Mailman School of Public Health challenges the long-standing view that inflammation is a universal feature of aging. The research indicates that “inflammaging”—a p

LLNL researchers use AI to look for potential ALS treatments

Potential treatments for amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases may already be out there in the form of drugs prescribed for other conditions. A team of researchers from Lawrence Livermore National Laboratory (LLNL), Stanford University and the University of California, Los Angeles (UCLA) are using artificial intelligence and machine learning (AI/ML) to try to find them.

Clinical trials for new drugs can take up to 5–7 years, so repurposing existing drugs is one of the best ways to deliver treatments quickly. AI/ML can make it even faster. By analyzing long-term electronic health records (EHRs) of patients with ALS, the team can identify drugs — or combinations of drugs — prescribed for other conditions that may influence the progression of the disease. The drugs’ “off-target” effects may not only affect patient survival but also provide insight into how neurodegenerative diseases work and inform better therapies.

“If you talk to any ALS caregiver, you will be moved because the disease has such a grim prognosis, so being able to do something is tremendously motivating,” said Priyadip Ray, a staff scientist in LLNL’s Computational Engineering Division (CED) who leads the effort.

Planets may start forming before stars even finish growing

New high-resolution images of protoplanetary disks in the Ophiuchus star-forming region, created with improved analysis. The resolution is shown by the white ellipse in the lower left of each panel, with a smaller ellipse indicating higher resolution. The white line in the lower right of each panel indicates a scale of 30 au. The evolution stage of the central stars progresses from left to right, and from top to bottom in the same row. (Credit: ALMA(ESO/NAOJ/NRAO), A. Shoshi et al.)

In a stellar nursery 460 light-years away, astronomers sharpened old ALMA data and spotted crisp rings and spirals swirling around 27 infant stars—evidence that planets start taking shape just a few hundred thousand years after their suns ignite, far earlier than anyone expected.

Signs of planet formation may appear earlier than expected around still-forming baby stars, according to new results of higher resolution images produced using new improved techniques to reanalyze radio astronomy archive data. These newly discovered signs of planet formation will provide a better understanding of when it begins around a young star, thereby elucidating the process that leads to planet formation, including habitable planets like Earth.