Prebiotic molecules central to life’s earliest metabolic processes—chemical reactions in cells that change food into energy—may have been born in deep space long before Earth existed, according to new research from the University of Hawaiʻi at Mānoa Department of Chemistry.
Scientists in the W. M. Keck Research Laboratory in Astrochemistry have recreated the extreme conditions found in dense interstellar clouds and discovered a way for the complete set of complex carboxylic acids—critical ingredients in modern metabolism—to form without life on timescales equivalent to a few million years.
The study, published in the Proceedings of the National Academy of Sciences, focused on molecules such as those in the Krebs cycle, a fundamental metabolic pathway used by nearly all living organisms. These molecules, which help break down nutrients to release energy, may have cosmic origins, forming in the icy, low-temperature environments of interstellar space.
