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Getting mRNA into the brain could allow scientists to instruct brain cells to produce therapeutic proteins that can help treat or prevent disease by replacing missing proteins, reducing harmful ones, or activating the body’s defenses.

The research team designed and tested a library of lipids to optimize their ability to cross the blood-brain barrier. Through a series of structural and functional analyses, they identified a lead formulation, termed MK16 BLNP, that exhibited significantly higher mRNA delivery efficiency than existing lipid nanoparticles approved by the Food and Drug Administration (FDA). This system takes advantage of natural transport mechanisms within the blood-brain barrier, including caveolae-and γ-secretase-mediated transcytosis, to move nanoparticles across the barrier, say the investigators.

In studies using mouse models of disease, the BLNP platform successfully delivered therapeutic mRNAs to the brain, demonstrating its potential for clinical application.

Scientists have developed a lipid nanoparticle system capable of delivering messenger RNA (mRNA) to the brain via intravenous injection, a challenge that has long been limited by the protective nature of the blood-brain barrier.

The findings, in mouse models and isolated human brain tissue, were published in Nature Materials. They demonstrate the potential of this technology to pave the way for future treatments for a wide range of conditions such as Alzheimer’s disease, amyotrophic lateral sclerosis, brain cancer, and drug addiction.

The blood-brain barrier serves as a protective shield, preventing many substances—including potentially beneficial therapies—from reaching the brain. While previous research introduced a platform for transporting large biomolecules such as proteins and oligonucleotides into the central nervous system, this new study focuses on a different approach: using specially designed lipid nanoparticles to transport mRNA across the barrier.

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We are in the middle of a big website upgrade and it just gave a bit of results: John Cena is now following us on X! Our account on X is https://twitter.com/LifeboatHQ

T know, here is info about John Cena: https://en.wikipedia.org/wiki/John_Cena

Check out our 3 new books at https://lifeboat.com/ex/books! Programs at https://lifeboat.com/ex/programs.

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This innovation, called ALA-CART, helps the immune system better recognize and destroy resistant cancers. The new design not only improves treatment success but also promises fewer side effects.

A Powerful Upgrade to CAR-T Therapy

Researchers at the University of Colorado Anschutz Medical Campus have developed an enhanced version of CAR-T cell therapy designed to improve effectiveness and longevity, particularly against cancer cells that were previously difficult to detect and eliminate.

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Scientists have achieved their initial goal of converting light into a supersolid material that unites solid-stage characteristics with those of superfluids. The discovery establishes paths toward studying uncommon quantum nature states of matter while carrying great implications for technological growth.

The matter form known as a supersolid behaves as both a solid and shows the properties of a superfluid. Despite keeping its rigid arrangement, the material demonstrates smooth flow while remaining non-frictional. Theoretical research on supersolids as a matter state has continued for decades since scientists first considered them in the 1970s. Through precise conditions, scientists believe materials can develop combined solid and superfluid properties to produce an absolute natural anomaly.

The discovery shows how particular materials become supple when exposed to exceptionally cold temperatures because they transition into a viscosity-free state. The dual properties of rigidness combined with fluidity create an extraordinary phase called supersolid in matter. Traditional materials possess two distinct states because solids maintain their shape, yet liquids possess free movement. Supersolids demonstrate behaviour beyond normal fluid-solid definitions because they exhibit features of both states.

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Sunburns and aging skin are obvious effects of exposure to harmful UV rays, tobacco smoke and other carcinogens. But the effects aren’t just skin deep. Inside the body, DNA is literally being torn apart.

Understanding how the body heals and protects itself from DNA damage is vital for treating genetic disorders and life-threatening diseases such as cancer. But despite numerous studies and medical advances, much about the molecular mechanisms of DNA repair remains a mystery.

For the past several years, researchers at Georgia State University have tapped into the Summit supercomputer at the Department of Energy’s Oak Ridge National Laboratory to study an elaborate molecular pathway called (NER). NER relies on an array of highly dynamic protein complexes to cut out (excise) damaged DNA with surgical precision.

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Over the past two years, the U.S. Centers for Disease Control and Prevention (CDC) has issued Travel Health Advisories focused on measles outbreaks.

These advisories highlight where there is an active health risk when people visit the highlighted countries.

On February 21, 2025, the CDC reissued a Level 1, Practice Usual Precautions, alert for 57 countries. This CDC list does not integrate the Region of the Americas, with numerous countries reporting 537 measles outbreaks this year.

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In anticipation for my next public lecture, the organizer requested the title of my lecture. I suggested: “Hunting for Aliens.” The organizer expressed concern that some members of the audience might confuse me for a U.S. government employee in search of illegal aliens near the southern border wall. I explained that no two-dimensional wall erected on Earth would protect us from extraterrestrials because they will arrive from above. It is just a matter of time until we notice interstellar travelers arriving without a proper visa. A policy of deporting them back to their home exoplanet will be expensive — over a billion dollars per flight. The trip will also take a long time — over a billion years with conventional chemical propulsion. We will have to learn how to live with these aliens, and promote diversity and inclusion in a Galactic context.

The Sun formed in the last third of cosmic history, so we are relatively late to the party of interstellar travelers. Experienced travelers might have been engaged in their interstellar journeys for billions of years. To properly interpret their recorded diaries and photo albums in terms of the specific stars they visited, we would need to accurately interpret their time measurements.

Imagine an interstellar tourist wearing a mechanical analog watch. Such a timepiece is at best accurate to within 3 seconds per day, or equivalently 30,000 years per billion years. This timing error is comparable to the amount of time it takes to hop from one star to another with chemical propulsion. Interstellar travelers must wear better clocks in order to have a reliable record of time.

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A new analysis reveals complex linkages among the United Nations’ (UN’s) 17 Sustainable Development Goals—which include such objectives as gender equality and quality education—and finds that no country is on track to meet all 17 goals by the target year of 2030.

Alberto García-Rodríguez of Universidad Nacional Autónoma de México and colleagues present these findings in the open-access journal PLOS One.

In 2015, UN member countries adopted the Sustainable Development Goals with the aim of achieving “peace and prosperity for people and the planet.” However, setbacks such as the COVID-19 pandemic, , and have slowed progress, and more research is needed to clarify the underlying obstacles so they can be effectively addressed.

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Scientists at Nanyang Technological University, Singapore (NTU Singapore), have developed an innovative solar-powered method to transform sewage sludge—a by-product of wastewater treatment—into green hydrogen for clean energy and single-cell protein for animal feed.

Published in Nature Water, the sludge-to-food-and-fuel method tackles two pressing global challenges: managing waste and generating sustainable resources. This aligns with NTU’s goal of addressing humanity’s greatest challenges, such as climate change and sustainability.

The United Nations estimates that about 2.5 billion more people will be living in cities by 2050. Along with the growth of cities and industries comes an increase in , which is notoriously difficult to process and dispose of due to its complex structure, composition, and contaminants such as and pathogens.

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