Lifeboat Foundation: Safeguarding Humanity
Toggle light / dark theme

Blog – Page 6

Get the latest international news and world events from around the world.

Log in for authorized contributors

Fiber-Fed 3D Printing of Germanate Glass Optics

In recent years, 3D printing glass optics has gained massive attention in industry and academia since glass could be an ideal material to make optical elements, including the lens. However, the limitation of materials and printing methods has prevented 3D printing glass optics progress. Therefore, we have developed a novel printing strategy for germanate glass printing instead of pure silica. Moreover, compared with traditional multi-component quartz glass, germanate glass has unmatched advantages for its mid-infrared (MIR) transparency and outstanding visible light imaging performance. Furthermore, compared with non-oxide glass (fluoride glass and chalcogenide glass), germanate glass has much better mechanical, physical, and chemical properties and a high refractive index.

What Can a Cell Remember?

In a provocative study published in Nature Communications late last year, the neuroscientist Nikolay Kukushkin and his mentor Thomas J. Carew at New York University showed that human kidney cells growing in a dish can “remember” patterns of chemical signals when they’re presented at regularly spaced intervals — a memory phenomenon common to all animals, but unseen outside the nervous system until now. Kukushkin is part of a small but enthusiastic cohort of researchers studying “aneural,” or brainless, forms of memory. What does a cell know of itself? So far, their research suggests that the answer to McClintock’s question might be: much more than you think.

Brainless Learning

The prevailing wisdom in neuroscience has long been that memory and learning are consequences of “synaptic plasticity” in the brain. The connections between clusters of neurons simultaneously active during an experience strengthen into networks that remain active even after the experience has passed, perpetuating it as a memory. This phenomenon, expressed by the adage “Neurons that fire together, wire together,” has shaped our understanding of memory for the better part of a century. But if solitary nonneural cells can also remember and learn, then networks of neurons can’t be the whole story.

Lactate infusion improves cardiac function in a porcine model of ischemic cardiogenic shock

Cardiogenic shock (CS) is associated with high mortality and medical therapies have failed to improve survival. Treatment with lactate is associated with improved cardiac function which may benefit this condition. Comprehensive hemodynamic assessment of lactate administration in CS is lacking, and the mechanisms underlying the cardiovascular effects of lactate in CS have not yet been elucidated. In this study we aimed to study the cardiovascular and cardiometabolic effects of treatment with lactate in experimental ischemic CS.

In a randomized, blinded design, 20 female pigs (60 kg) were studied. Left main coronary artery microsphere injections were used to cause CS, defined as a 30% reduction in CO or mixed venous saturation (SvO2). Subjects were randomized to receive either intravenous exogenous lactate or euvolemic, equimolar saline (control) for 180 min. Positive inotropic control with dobutamine was administered on top of ongoing treatment after 180 min. Extensive hemodynamic measurements were obtained from pulmonary artery and left ventricular (LV) pressure–volume catheterization. Furthermore, endomyocardial biopsies were analyzed for mitochondrial function and arterial, renal vein, and coronary sinus blood samples were collected. The primary endpoint was change in CO during 180 min of treatment.

Arterial lactate levels increased from 2.4 ± 1.1 to 7.7 ± 1.1 mmol/L (P 0.001) during lactate infusion. CO increased by 0.7 L/min (P 0.001) compared with control, due to increased stroke volume (P = 0.003). Notably, heart rate and mean arterial pressure did not differ significantly between treatments. End-systolic elastance (load independent contractility) was enhanced during lactate infusion (P = 0.048), together with LV ejection fraction (P = 0.009) and dP/dt(max) (P = 0.041). Arterial elastance (afterload) did not differ significantly (P = 0.12). This resulted in improved ventriculo-arterial coupling efficiency (P = 0.012). Cardiac mechanical efficiency (P = 0.003), diuresis (P = 0.016), and SvO2 (P = 0.018) were increased during lactate infusion. Myocardial mitochondrial complex I respiration was enhanced during lactate infusion compared with control (P = 0.04).

Potential chemo-induced cognitive changes discovered in cancer survivors

Researchers at The City College of New York have linked chemotherapy treatment to lasting cognitive changes in rats—potentially shedding light, for the first time, on cognitive problems some cancer survivors experience long after treatment ends.

Titled “Chemotherapy treatment alters DNA methylation patterns in the of female rat brain,” the study appears in the journal Scientific Reports.

“Our study explored how chemotherapy affects the brain at the using an ,” said Karen Hubbard, professor of biology in CCNY’s Division of Science, who co-led the study.

Molecular imaging uncovers hidden flaws in plastics used for electronics

A new study uncovers revealing insights into how plastic materials used in electronics are formed, and how hidden flaws in their structure could be limiting their performance.

Conjugated polymers are a type of plastic that conduct electricity and are used in optoelectronics, computing, biosensors, and power generation. The materials are lightweight, low-cost, and can be printed in thin layers onto flexible substrates, making them ideal for next-generation technologies.

An international team of scientists investigated a popular method for making the polymers called aldol condensation, which is praised for being versatile, metal-free, environmentally friendly, and scalable.

Socioeconomic Factors Associated With Migraine Medication Prescription at a Tertiary Headache CenterA Retrospective Cohort Analysis

Background and ObjectivesThe socioeconomic and demographic factors affecting the prescription of migraine medications are underexplored. Understanding these factors is critical to addressing health. We used our tertiary headache center’s prescription…

Northeastern discovery in quantum materials could make electronics 1,000 times faster

Researchers at Northeastern University have discovered how to change the electronic state of matter on demand, a breakthrough that could make electronics 1,000 times faster and more efficient.

By switching from insulating to conducting and vice versa, the discovery creates the potential to replace silicon components in electronics with exponentially smaller and faster quantum materials.

“Processors work in gigahertz right now,” said Alberto de la Torre, assistant professor of physics and lead author of the research. “The speed of change that this would enable would allow you to go to terahertz.”

Northeastern researchers discovered how to control quantum materials with light, potentially making electronics 1,000 times faster.

Additive Manufacturing Enables Advanced Thermal Control Systems for Next-Generation Space Missions

3D Systems is collaborating with researchers from Penn State University and Arizona State University on two projects sponsored by NASA intended to enable groundbreaking alternatives to current thermal management solutions.

Severe temperature fluctuations in space can damage sensitive spacecraft components, resulting in mission failure. By combining deep applications expertise with 3D Systems’ leading additive manufacturing solutions comprising Direct Metal Printing (DMP) technology and tailored materials and Oqton’s 3DXpert® software, the teams are engineering sophisticated thermal management solutions for the demands of next-generation satellites and space exploration.

The project led by researchers with Penn State University, Arizona State University, and the NASA Glenn Research Center in collaboration with 3D Systems’ Application Innovation Group (AIG) has resulted in processes to build embedded high-temperature passive heat pipes in heat rejection radiators that are additively manufactured in titanium. These heat pipe radiators are 50 percent lighter per area with increased operating temperatures compared with current state-of-the-art radiators, allowing them to radiate heat more efficiently for high-power systems.

By combining deep applications expertise with 3D Systems’ leading additive manufacturing solutions, research teams are engineering sophisticated thermal management solutions for the demands of next-generation satellites and space exploration.

Blood proteome regulation to control inflammation, age-associated organ dysfunction and mortality in sepsis

The amount of each of the more than a thousand different glycoproteins in your blood varies widely with the 10 most abundant glycoproteins accounting for 90 percent of the total mass. Finding a protein that isn’t in this top 10 is a bit like looking for Waldo if only one rendition of the character remained in a collection of every “Where’s Waldo” comic ever produced.

This range of disparity in protein concentration is termed dynamic range, and it makes it more difficult for scientists to identify less-abundant proteins and their matching receptors.

Scientists published findings in Nature Communications demonstrating a strategy for identifying less-abundant proteins that bind with a specific type of receptor termed an endocytic lectin, and namely the mannose receptor Mrc1 (also known as CD206 and MMR). This approach enabled the research team to uncover hundreds of binding partners that together predicted Mrc1’s roles in our health.