Lifeboat Foundation: Safeguarding Humanity
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When it comes to upgrading electrical and broadband infrastructure, new research from the University of Massachusetts Amherst shows that a “dig once” approach is nearly 40% more cost effective than replacing them separately.

The study, published in the journal Cell Reports Sustainability, also found that the greatest benefit comes from proactively undergrounding lines that are currently above ground, even if lines haven’t reached the end of their usefulness.

Co-undergrounding is the practice of burying both electric and broadband internet lines together.

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About 66 million years ago, an asteroid slammed into the planet, wiping out all non-avian dinosaurs and about 70% of all marine species.

But the crater it left behind in the Gulf of Mexico was a literal hotbed for life, enriching the overlying ocean for at least 700,000 years, according to research published today in Nature Communications.

Scientists have discovered that a hydrothermal system created by the asteroid impact may have helped marine life flourish at the impact site by generating and circulating nutrients in the crater environment.

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Individuals who were conceived in colder seasons are more likely to show higher brown adipose tissue activity, increased energy expenditure and a lower body mass index (BMI), and lower fat accumulation around internal organs, compared with those conceived in warmer seasons, suggests a study published in Nature Metabolism. The findings, based on an analysis involving more than 500 participants, indicate a potential role for meteorological conditions influencing human physiology.

Although eating habits and exercise are key indicators of fat loss, exposure to cold and warmth also plays a part. In colder temperatures, the body generates more heat (cold-induced thermogenesis) via brown adipose tissue activity and stores less fat in the form of white adipose tissue than it does in hotter temperatures. However, underlying factors contributing to in brown adipose tissue activity remain poorly understood, particularly in humans.

Takeshi Yoneshiro and colleagues analyzed brown adipose tissue density, activity and thermogenesis in 683 healthy male and female individuals between ages 3 and 78 in Japan, whose parents were exposed to (defined in the study as between 17 October and 15 April) or warm temperatures (between 16 April and 16 October) during the fertilization and birth periods.

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Anyone who’s ever tried tiling a floor, a backsplash or even an arts-and-crafts project probably knows the emotional frustration of working with pieces whose shapes don’t perfectly complement each other. It turns out, though, that some creatures may actually rely on similar mismatches to create geometric frustrations that result in complex natural structures with remarkable properties, such as protective shells and sturdy yet flexible bones.

Now, researchers at the University of Michigan have developed mathematical models showing one way that nature achieves this. These models, in turn, could help design advanced materials for medical devices, sustainable construction and more.

“Frustration—using these mismatched building blocks—gives rise to wonderful complexity and that complexity can be useful in providing superior material properties,” said Xiaoming Mao, U-M professor of physics and senior author of the new study.

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Damage to the mitochondria, the “power plants” of the cells, contributes to many diseases. Researchers from Heinrich Heine University Düsseldorf (HHU) and the University of Cologne led by HHU professor of medicine Dr David Pla-Martín, now describe in the scientific journal Science Advances how cells with defective mitochondria activate a special recycling system to eliminate damaged genetic material.

Damage to the genetic material of mitochondria – the mitochondrial DNA or mtDNA for short – can lead to diseases such as Parkinson’s, Alzheimer’s, amyotrophic lateral sclerosis (ALS), cardiovascular diseases and type 2 diabetes. Such damage also speeds up the ageing process. However, the cells are normally capable of identifying such damage and reacting.

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Damage to the genetic material of mitochondria—the mitochondrial DNA or mtDNA for short—can lead to diseases such as Parkinson’s, Alzheimer’s, amyotrophic lateral sclerosis (ALS), cardiovascular diseases and type 2 diabetes. Such damage also speeds up the aging process. However, the cells are normally capable of identifying such damage and reacting.

Scientists from University Hospital Düsseldorf and HHU have—in collaboration with the University of Cologne and the Center for Molecular Medicine Cologne (CMMC)—discovered a mechanism which protects and repairs the mitochondria. The research team, headed by Professor Pla-Martín from the Institute of Biochemistry and Molecular Biology I at HHU, has identified a specialized recycling system, which cells activate when they identify damage to the mtDNA.

According to the authors in Science Advances, this mechanism relies on a known as retromer and the lysosomes—cell organelles containing digestive enzymes. These special cellular compartments act like recycling centers, eliminating the damaged genetic material.

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