Lifeboat Foundation: Safeguarding Humanity
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A thought-provoking new article poses some hugely important scientific questions: Could brain cells initiated and grown in a lab become sentient? What would that look like, and how could scientists test for it? And would a sentient, lab-grown brain “organoid” have some kind of rights? Buckle up for a quick and dirty history of the ethics of sentience. We associate the term with computing and artificial intelligence, but the question of who (or what) is or isn’t “sentient” and deserving of rights and moral consideration goes back to the very beginning of the human experience. The debate colors everything from ethical consumption of meat to many episodes of Black Mirror.

Well, we don’t want that… or do we?

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Maya Ajmera, President & CEO of Society for Science & the Public and Publisher of Science News, chatted with Ray Kurzweil, an alumnus of the Science Talent Search and a renowned inventor and futurist. Kurzweil also has written five best-selling books, is Cofounder and Chancellor of Singularity University and is a Director of Engineering at Google. We are thrilled to share an edited summary of their conversation.

You are an alum of the1965Science Talent Search. How did the competition impact your life, and are there any particular moments that still stand out for you?

The Westinghouse Science Talent Search was the first time I was recognized nationally. President Johnson had just been elected and we met him at the White House. He told us his goal was that our generation would never see the horrors of war.

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In 2,001 Celera Genomics and the International Human Genome Sequencing Consortium published their initial drafts of the human genome, which revolutionized the field of genomics. While these drafts and the updates that followed effectively covered the euchromatic fraction of the genome, the heterochromatin and many other complex regions were left unfinished or erroneous. Addressing this remaining 8% of the genome, the Telomere-to-Telomere (T2T) Consortium has finished the first truly complete 3.055 billion base pair (bp) sequence of a human genome, representing the largest improvement to the human reference genome since its initial release. The new T2T-CHM13 reference includes gapless assemblies for all 22 autosomes plus Chromosome X, corrects numerous errors, and introduces nearly 200 million bp of novel sequence containing 2,226 paralogous gene copies, 115 of which are predicted to be protein coding. The newly completed regions include all centromeric satellite arrays and the short arms of all five acrocentric chromosomes, unlocking these complex regions of the genome to variational and functional studies for the first time.

The latest major update to the human reference genome was released by the Genome Reference Consortium (GRC) in2013and most recently patched in2019(GRCh38.p13). This assembly traces its origin to the publicly funded Human Genome Project and has been continually improved over the past two decades. Unlike the competing Celera assembly , and most modern genome projects that are also based on shotgun sequence assembly , the GRC human reference assembly is primarily based on Sanger sequencing data derived from bacterial artificial chromosome (BAC) clones that were ordered and oriented along the genome via radiation hybrid, genetic linkage, and fingerprint maps. This laborious approach resulted in what remains one of the most continuous and accurate reference genomes today. However, reliance on these technologies limited the assembly to only the euchromatic regions of the genome that could be reliably cloned into BACs, mapped, and assembled.

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Technion scientists have created a wearable motion sensor capable of identifying movements such as bending and twisting. This smart ‘e-skin’ was produced using a highly stretchable electronic material, which essentially forms an electronic skin capable of recognizing the range of movement human joints normally make, with up to half a degree precision.

This breakthrough is the result of collaborative work between researchers from different fields in the Laboratory for Nanomaterial-Based Devices, headed by Professor Hossam Haick from the Technion Wolfson Faculty of Chemical Engineering. It was recently published in Advanced Materials and was featured on the journal’s cover.

This wearable motion sensor, which senses bending and twisting, can be applied in healthcare and manufacturing.

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The Bernese theoretical astrophysicist Kevin Heng has achieved a rare feat: On paper, he has derived novel solutions to an old mathematical problem needed to calculate light reflections from planets and moons. Now, data can be interpreted in a simple way to understand planetary atmospheres, for example. The new formulae will likely be incorporated into future textbooks.

For millennia, humanity has observed the changing phases of the Moon. The rise and fall of sunlight reflected off the Moon, as it presents its different faces to us, is known as a “phase curve.” Measuring phase curves of the Moon and Solar System planets is an ancient branch of astronomy that goes back at least a century. The shapes of these phase curves encode information on the surfaces and atmospheres of these celestial bodies. In modern times, astronomers have measured the phase curves of exoplanets using space telescopes such as Hubble, Spitzer, TESS

Launched on April 18 2018, aboard a SpaceX Falcon 9 rocket, NASA’s Transiting Exoplanet Survey Satellite (TESS) is a mission to search nearby stars for undiscovered worlds with a gold of discovering thousands of exoplanets around nearby bright stars.

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One of the most difficult aspects of gene therapy might be ensuring that it gets into the right cells safely so it can have a therapeutic effect. Researchers have now created a new way to deliver various types of RNA cargo to cells, which utilizes one of the human body’s natural proteins to create particles that can bind to RNA. This approach, called SEND, may help reduce any immune response that would be mounted against a gene therapy. The work has been reported in Science.

Current delivery systems are not efficient, may integrate their cargo improperly, and can cause serious immune reactions. “The biomedical community has been developing powerful molecular therapeutics, but delivering them to cells in a precise and efficient way is challenging,” said senior study author Feng Zhang, Ph.D., a core institute member at the Broad Institute, among many other appointments. “SEND has the potential to overcome these challenges.”

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Belgium-based hydrogen solution company CMB.TECH and crane equipment developer Luyckx have presented what they believe to be the world’s first hydrogen-powered dual fuel excavator. The team has converted a 37 ton Hitachi ZX350LC-7 excavator to a dual fuel machine that can continue to operate on diesel if the supply of hydrogen is not available.

The dual-fuel excavator provides gradual ecological development within the heavy construction and earthmoving sector. With this machine, companies within the sector can embark on energy transition with today’s machines without being permanently dependent on the availability of hydrogen. The solution allows companies to take a first concrete step toward greening the entire heavy excavator sector without limiting the machine’s power or autonomy.

“Driven by the wishes of our end users and fleet owners, we launched an own-initiative feasibility study with regard to possible alternative solutions that help to reduce CO2 emissions, make the machine park more sustainable and do business in a socially responsible way. We have been looking for the right solutions for several years. The challenge was mainly in the area of energy requirements for heavy machinery,” said Jos Luyckx, the CEO of Luyckx.

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Volkner’s over-the-top motorhome package slides a 1,480-hp Bugatti Chiron aboard its $2.4-million Performance S motorhome and treats owners of the elaborate ultra-luxury/hypercar vehicle experience.

In the past, we’ve seen Volkner edge out its few competitors for “most expensive motorhome of the Düsseldorf Caravan Salon” honors with stretched luxury homes as “modestly” priced as $1.7 million. This year, it leaves the competition in the dust, going all out on the priciest, most over-the-top motorhome package on the show floor. It slides a 1,480-hp Bugatti Chiron aboard its $2.4-million Performance S motorhome and treats owners of the elaborate ultra-luxury/hypercar vehicle experience to a lavishly appointed abode complete with custom Burmester audio system carefully tailored to the mobile space.

For more than a decade, Volkner has been wowing the Düsseldorf crowds with the sporty roadsters and supercars it manages to squeeze between the axles of its huge motorhomes. This year, it’s really upped its own game.

The $3-million Bugatti Chiron actually costs more than the Performance S motorhome itself and packs more than triple the horsepower of Volkner’s 430-hp 18-ton 39-footer. We preferred the Porsche 911 GT2 Volkner brought to the 2018 Caravan Salon not a full year after the car’s Nürburgring record, but there’s no denying that the Chiron and Performance S team is an absolutely stunning package, a pairing of extreme, over-the-top motorized engineering like few we’ll ever see.

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