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Gene fusion may cause explosive growth in chronic myeloid leukaemia

A new study has unveiled when chronic myeloid leukaemia, a type of cancer that affects the blood and bone marrow, arises in life and how fast it grows. Researchers reveal explosive growth rates of cancerous cells years before diagnosis and variation in these rates of growth between patients. Such rapid growth rates had previously not been observed in most other cancers.

Researchers used whole genome sequencing to study when BCR::ABL1 – an abnormal fusion of the different genes called BCR and ABL1, which is known to cause chronic myeloid leukaemia. The team investigated when BCR::ABL1 first arises in a blood cell and how quickly these cells with this genetic change then multiply and expand to lead to a diagnosis of a type of leukaemia.

The research, published in Nature, contributes to the scientific understanding of how strong this abnormal fusion gene is in its ability to drive cancer.

Gödel pro and contra AI: dismissal of the case

Gödel’s incompleteness theorem is used by both advocates and adversaries of strong AI to show that computers can(not) perform the same feats as humans. This article extends the construction through which Gödel proved his theorem, in order to allow a broader interpretation, showing that neither side has exploited its arguments to the fullest extend, and that the evidence can never be conclusive.

Dr.ir. C.J.B. Jongeneel & prof.dr. H. Koppelaar, Delft University of Technology, Faculty of Technical Mathematics and Informatics, Section of Knowledge Based Systems.

1 Introduction

Small molecules restore mutant mitochondrial DNA polymerase activity

Mitochondrial diseases caused by POLG mutations vary in severity. In young children, these diseases can quickly result in brain damage and life-threatening liver problems while others suffer muscle weakness, epilepsy, and organ failure later in childhood. POLG mutations recently received media attention when Prince Frederik of Nassau in Luxembourg died in March 2025 at just 22 years of age.

Distinct synaptic plasticity rules operate across dendritic compartments in vivo during learning

Synaptic plasticity underlies learning by modifying specific synaptic inputs to reshape neural activity and behavior. However, the rules governing which synapses will undergo different forms of plasticity in vivo during learning and whether these rules…

Scientists discover pioneering technique to accelerate accurate quantum measurements

Researchers have developed a new way to speed up quantum measurements, a vital building block for the next generation of quantum technologies.

Accurate and fast will be crucial for , but are fragile and susceptible to disturbance which can cause errors. Previous work in this area presented a fundamental challenge—scientists were only able to increase the accuracy of measurements in quantum systems by sacrificing speed.

A team of quantum experts, led by the University of Bristol, have struck upon a novel way to overcome this problem, published in a Physical Review Letters journal paper.

“France Can’t Do It Alone”: U.S. Delivers 60-Foot Superconducting Magnet Beast Crucial to the $22 Billion ITER Nuclear Fusion Dream

IN A NUTSHELL 🔧 The United States has delivered a colossal superconducting magnet to France’s ITER project, advancing nuclear fusion technology. 🤝 Collaboration among eight American companies was essential to construct the solenoid’s support structure for the reactor. 🔄 Four out of six solenoid modules have been installed, with completion expected by the year’s end.

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