Lifeboat Foundation

Circulating branched-chain amino acids (BCAAs) are elevated in obesity and diabetes, and recent studies support a causal role for BCAAs in insulin resistance and defective glycemic control. The physiological mechanisms underlying BCAA regulation are poorly understood. Here we show that insulin signaling in the mediobasal hypothalamus (MBH) of rats is mandatory for lowering plasma BCAAs, most probably by inducing hepatic BCAA catabolism. Insulin receptor deletion only in agouti-related protein (AgRP)–expressing neurons (AgRP neurons) in the MBH impaired hepatic BCAA breakdown and suppression of plasma BCAAs during hyperinsulinemic clamps in mice. In support of this, chemogenetic stimulation of AgRP neurons in the absence of food significantly raised plasma BCAAs and impaired hepatic BCAA degradation.

During the past two decades, cognitive neuroscientists have sought to elucidate the common neural basis of the experience of beauty. Still, empirical evidence for such common neural basis of different forms of beauty is not conclusive. To address this question, we performed an activation likelihood estimation (ALE) meta-analysis on the existing neuroimaging studies of beauty appreciation of faces and visual art by nonexpert adults (49 studies, 982 participants, meta-data are available at https://osf.io/s9xds/). We observed that perceiving these two forms of beauty activated distinct brain regions: While the beauty of faces convergently activated the left ventral striatum, the beauty of visual art convergently activated the anterior medial prefrontal cortex (aMPFC). However, a conjunction analysis failed to reveal any common brain regions for the beauty of visual art and faces.

Tianzhou cargo spacecraft to visit module also passes review.

Batteries and hybrid renewables-plus-storage projects will be a massive grid resource. Transmission grids and energy markets will need to adapt.

COOl.

“The spacecraft, dubbed Hope, launched July 192020, atop a Japanese H-IIA rocket, then spent seven months trekking to the Red Planet. Today (Feb. 9), Hope needed to fire its thrusters for nearly half an hour straight to slow down enough to slip into orbit around the Red Planet, from 75000 mph to 11000 mph (121000 kph to 18000 kph). Mission personnel on the ground could only watch what happened and hope for the best. “This has been a remarkable journey of humanity,” UAE Space Agency chairperson Sarah Al Amiri said during preparations for the orbital insertion maneuver. With the successful Mars orbit insertion, the UAE becomes the fifth entity to reach the Red Planet, joining NASA, the Soviet Union, the European Space Agency and India. Today’s success also puts the $200 million Hope spacecraft on the bright side of grim Mars mission statistics: About half of flights to the Red Planet fail.”

The milestone comes little more than a decade after the country launched its first satellite.

2 things I like here. 1. Aubrey says not only does he think the first person to live to 1000 may be alive today but that they are already middle aged(Like me!). 2. In 15 years we might give a 70 year old treatment that will not make them 20 again, but perhaps it will make them 40. then by the time they hit 70 again the treatments available will be even better.

Dr. Aubrey de Grey is a biomedical gerontologist based in Mountain View, California, USA, and is the Chief Science Officer of SENS Research Foundation, a California-based 501©(3) biomedical research charity that performs and funds laboratory research dedicated to combating aging. In addition, he is Editor-in-Chief of Rejuvenation Research, the world’s highest-impact peer-reviewed journal focused on intervention in aging. He received his BA in computer science and Ph.D. in biology from the University of Cambridge. His research interests encompass the characterization of all the types of self-inflicted cellular and molecular damage that constitute mammalian aging and the design of interventions to repair and/or obviate that damage. Dr. de Grey is a Fellow of both the Gerontological Society of America and the American Aging Association, and sits on the editorial and scientific advisory boards of numerous journals and organizations. He is a highly sought-after speaker who gives 40–50 invited talks per year at scientific conferences, universities, companies in areas ranging from pharma to life insurance, and to the public. Topics Discussed: Brief overview of SENS
- Why try to end aging?
- How soon do you think we will end aging?
- What role does rejuvenation biotech play in the COVID-19 pandemic? How would regenerative medicine help us better cope with the pandemic?
- How are you implementing the techniques you research in your own life?
- Which breakthrough are you most proud of?Aubrey’s Links: LinkedIn: https://www.linkedin.com/in/aubrey-de-grey-24260b/
Personal Website: https://www.sens.org/
Company Website: https://www.mfoundation.org/
Twitter: https://twitter.com/aubreydegreyListen to the audio version at: https://www.buzzsprout.com/765170/7722976-dr-aubrey-de-grey-…e-agingYou can listen to the audio and read the transcript here: https://podcast.boomerliving.tv/dr-aubrey-de-grey-what-cause…-aging/You can listen to many other audio podcasts on our website and Apple Podcasts: https://podcast.boomerliving.tv/
https://podcasts.apple.com/us/podcast/boomer-living-senior-l…1455929808

Boston Dynamics, famous for its highly mobile robots, has announced an expanded product line for the agile ‘Spot’.