Each year, billions of tons of goods are transported globally using cargo containers. Currently, there are concerns that this immense volume of traffic could be exploited to transport illicit nuclear materials, with little chance of detection. One promising approach to combating this issue is to measure how goods interact with charged particles named muons—which form naturally as cosmic rays interact with Earth’s atmosphere. Studies worldwide have now explored how this technique, named “muon tomography,” can be achieved through a variety of detection technologies and reconstruction algorithms. In this article of EPJ Plus, a team headed by Francesco Riggi at the University of Catania, Italy, build on these results to develop a full-scale muon tomograph prototype.