Lifeboat Foundation

RNA-binding proteins (RBPs) are critical effectors of gene expression, and as such their malfunction underlies the origin of many diseases. RBPs can recognize hundreds of transcripts and form extensive regulatory networks that help to maintain cell homeostasis. System-wide unbiased identification of RBPs has increased the number of recognized RBPs into the four-digit range and revealed new paradigms: from the prevalence of structurally disordered RNA-binding regions with roles in the formation of membraneless organelles to unsuspected and potentially pervasive connections between intermediary metabolism and RNA regulation. Together with an increasingly detailed understanding of molecular mechanisms of RBP function, these insights are facilitating the development of new therapies to treat malignancies. Here, we provide an overview of RBPs involved in human genetic disorders, both Mendelian and somatic, and discuss emerging aspects in the field with emphasis on molecular mechanisms of disease and therapeutic interventions.

An international team of scientist from the United States, the United Kingdom and Taiwan has developed the world’s smallest memristor. Their results appear in the journal Nature Nanotechnology.

In the new work, the researchers reduced the size even further, shrinking the cross section area down to just a single square nanometer.

Scholars have a nifty way of alerting colleagues to lengthy treatises that they find simply not worth their time to read.

They tag such documents “tl;dr”—too long, didn’t read.

It’s kind of a 21st century spin on the 420-year-old notion Shakespeare’s Polonius relayed to the king and queen in “Hamlet”: “Brevity,” he suggested, “is the soul of wit.”

Adagrasib demonstrated an acceptable safety profile and promising clinical activity in pretreated patients with non-small cell lung cancer, colorectal cancer, and other solid tumors with a KRAS G12C mutation.

Styrofoam has been nicknamed “public enemy No. 6” because it’s more likely to be landfilled or washed into the ocean than recycled. But three Canadian startups are launching technology that aims to make discarded polystyrene containers, packaging and products a resource that everyone wants to recycle.

Paging Philip Pullman.

https://www.youtube.com/c/EcstadelicMedia

Group, San Francisco, CA | PR, Digital Media & Publishing Company | www.ecstadelic.net ecstadelic — adj. Ecstasy-inducing, stimulating ecsta…

Might interest some as it mentions telomeres.

The historic NASA Twins Study investigated identical twin astronauts Scott and Mark Kelly and provided new information on the health effects of spending time in space.

Colorado State University Professor Susan Bailey was one of more than 80 scientists across 12 universities who conducted research on the textbook experiment; Mark remained on Earth while Scott orbited high above for nearly one year. The massive effort was coordinated by NASA’s Human Research Program.

Continue reading “Research provides new insights on health effects of long-duration space flight” »

I actually had this album before there was an 867‑5309. Some great songs!

1:28 PM
Tommy Tutone at “The Church“
Marin County California 1979
Tommy Heath Guitar and Lead Vocals.
Jim Keller Lead Guitar and Vocals.
Terry Nails Bass.
Mickey Shine Drums.

Continue reading “Tommy Tutone — Cheap Date” »