In vitro digestion of genomic DNA with Cas9 and single guide RNAs (sgRNAs) yields genome-wide off-target sites at frequencies below 0.1%. Off-target sites can be further reduced with modified sgRNAs.
Martian soil needs a little bacteria to house plants.
The findings were detailed in a study published Wednesday in PLOS One.
The recent experiment is a crucial step in humanity’s vision of inhabiting a planet other than Earth, addressing the need to grow plants and crops to maintain a sustainable environment.
As scientists search for a place that could potentially host humans, Mars is at the top of the list.
Image-guided radiation therapy has evolved to include the ability to track tumors in real time during treatment. It’s improving cure rates and limiting side effects for a growing number of cancer patients.
Think of it like radio making way for television. For more than a century, radiation therapy has been effective in treating cancer. From the first X-rays, to today’s computed tomography (CT) scans, physicians have relied on various imaging techniques to locate tumors and guide their treatment. Enter real-time tumor tracking.
“Magnetic Resonance-guided therapy is really a new paradigm,” said Dr. Rodney Ellis, chair of the Department of Radiation Oncology at Penn State Health Milton S. Hershey Medical Center. He notes the leading-edge technology merges MRI (Magnetic Resonance Imaging) with a linear accelerator, making it possible to reshape radiation dosage based on daily changes in a tumor’s shape, size and position and its surrounding healthy anatomy.
Efforts to study the early stages of the coronavirus pandemic have received help from a surprising source. A biologist in the United States has ‘excavated’ partial SARS-CoV-2 genome sequences from the beginnings of the pandemic’s probable epicentre in Wuhan, China, that were deposited — but later removed — from a US government database.
The partial genome sequences address an evolutionary conundrum about the early genetic diversity of the coronavirus SARS-CoV-2, although scientists emphasize that they do not shed light on its origins. Nor is it fully clear why researchers at Wuhan University asked for the sequences to be removed from the Sequence Read Archive (SRA), a repository for raw sequencing data maintained by the National Center for Biotechnology Information (NCBI), part of the US National Institutes of Health (NIH).
Partial SARS-CoV-2 sequences from early outbreaks in Wuhan were removed from a US government database by the scientists who deposited them.
Merck and Ridgeback Biotherapeutics announced on Friday early result that indicate their experimental oral antiviral drug molnupiravir might halve the risk of death or hospitalization from Covid-19.
In a news release, the company said 7.3% of 385 patients who received the antiviral were either hospitalized or died from Covid-19, compared with 14.1% of the 377 patients who received a placebo, which does nothing.
Full data from the molnupiravir trial has not yet been released, and this data has not yet been peer-reviewed or published. But Merck says it will seek authorization from the US Food and Drug Administration, and if it’s granted, the drug could be the first antiviral treatment available orally to fight Covid-19.
Designing a society that can adapt to the rise of artificial intelligence and allow everyone to thrive as these changes unfold is likely to be one of our most significant challenges in the coming years and decades. It will require an emphasis on retraining and education for those workers who can realistically undertake the necessary transition, as well as an improved safety net – and perhaps an entirely new social contract – for those who will inevitably be left behind.
From fast food to farming, Covid-19 has accelerated the rise of the worker robots. This in turn will put more jobs at risk and makes the need to reframe society ever more urgent.
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Posted in biotech/medical, computing
The computer program used for capturing in vitro RGEN cleavage sites in sequenced genomes is available at.
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One Vaccine to Rule Them All
Posted in biotech/medical, futurism
In the spring, a team of University of Virginia and Virginia Tech scientists shared some exciting news: The vaccine they are developing showed promising results in early animal trials not only for COVID-19, but for other coronaviruses.
If that trend continues through further testing, this vaccine could help contain both current and future variants of the COVID-19 virus — including the Delta variant currently plaguing the United States, and other variants that might crop up in the coming months and years. It could even protect against other coronaviruses, including viruses that cause the common cold. And, it could cost as little as $1 a dose.
What if we had a vaccine that would work for any COVID-19 variants that might pop up – and even for some coronaviruses that cause the common cold? UVA and Virginia Tech scientists are working on it.
Head to https://www.wren.co/start/techspace for more informations!
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SpaceX is building the most powerful spacecraft ever with the Starship. When completed, clients are waiting to put it to different uses as it is a very versatile spacecraft and this is because SpaceX is making it to be 100 percent reusable. However, for SpaceX, the Starship is its vehicle to explore the unknown parts of the solar system.
How is SpaceX making sure the Starship is fit for the long journeys the spacecraft is destined for?
Join us as we examine SpaceX’s insane plan to travel all over the Solar system!
When the Starship is ready, SpaceX would have the most powerful spacecraft in its hands. When the upper stage, the Ship, and the lower stage, the Super Heavy, are stacked together, the Starship will stand an impressive 120 meters tall, with a diameter of nine meters and total payload to lower earth orbit of over 100 tons.
The booster is the Super Heavy, a colossal steel structure that is 70 meters tall. It will lift a gross mass of over 3 million kg by producing a thrust of 72 MN. The booster relies on 32 Raptor engines that SpaceX is designing in-house. The rocket engines will use propellants made of sub-cooled liquid methane and liquid oxygen, of which the booster can store 3,400 tons.
SpaceX designed reusability into the Super Heavy so it can be used for multiple mission launches. The booster was to return to earth and land on its six legs but to reduce costs and turn around time, SpaceX ditched the legs, instead, coming up with the radical idea of catching the Super Heavy with a pair of arms, known as the Mechazilla, on the launch tower. It will be aided on its return journey by a system of four grid fins.
The upper stage or the Ship is the part of the Starship that will go to and return from space. It is a 50 meters tall spacecraft that can carry both cargo and passengers to earth’s orbit and beyond. It will rely on six Raptor engines both for propulsion and landing since it is also completely reusable.
The Ship also uses methane and oxygen propellants, of which it can store 1,200 tons, but it has an ingenious proposed method of getting more fuel when out there in space, as we shall see later.
While the Ship will also be caught by the Mechazilla, on its return to earth, SpaceX is retaining the legs so that it can land on other planets or the moon where there is no Mechazilla.
Out of the 50-meter height of the Ship, 18 meters of it will be available to configure either for cargo or passenger transport, making it the largest usable payload volume of any current or in-development launcher.
If you ever wonder what I like to do when not making these videos, I like taking road trips. I also look forward to taking flights to see my folks and reconnect with my roots. Sometimes, I hang out with friends over a few chilled beers. I felt I was just having fun, until a pal hooked me up to Wren, which helped me to see how much my fun activities were adding carbon emissions to the air.
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The Starship is not a product that will struggle for business as many people are waiting on it.
One of its most prominent suitors is NASA, which is confident enough to put 2.9 billion dollars into its development.
Stimulating STEM Innovation & Securing U.S. High-Tech Economy — Kimberly A. Reed, Fmr President and Chairman Export-Import Bank of the United States.
Kimberly A. Reed just finished up a 2-year term as President and Chairman of the Board of Directors of the Export-Import Bank of the United States (EXIM — https://www.exim.gov). She was the first woman to lead EXIM in the agency’s 87-year history, was the first recipient of EXIM’s highest honor, the Franklin D. Roosevelt Award, and was confirmed by the U.S. Senate in 2019 on a strong bi-partisan basis.
EXIM provides loans, guarantees, and export credit insurance for the export of U.S. goods and services from enterprises ranging from Fortune 100 companies to small businesses in a multitude of sectors including infrastructure, power, agriculture, transportation/aviation, health care, commodities, industrial, and technology.
Ms. Reed was recognized for successfully navigating Congress to re-open EXIM after four years of dormancy and transforming the mission and impact of the 515-person independent federal agency.
Ms. Reed also spearheaded EXIM’s historic, longest-ever Congressional re-authorization of seven years and a significant new mandate, the Program on China and Transformational Exports, which focuses on industries including biomedical sciences, biotechnology, wireless communication (5G), renewable energy, financial technologies, artificial intelligence, and the space industry.