Scientists are using ever more sophisticated AI algorithms trained on vast, unlabeled datasets to develop models that can ‘interpret’ biological data to help guide biomolecule design.
Randal Koene discusses Whole Brain Emulation on the H+ Magazine podcast. He touches on the subjects of connectomics, neural mapping, optogenetics, and neural prosthesis.
Muir et al. explore threat discrimination in male and female mice and find that, despite similar behavioral acquisition, there are surprising sex differences in the neural encoding that drives suppression of reward seeking under threat.
Single-cell profiling in the human cortex reveals aging-associated transcriptomic changes across all brain cell types, which overlap with effects with Alzheimer’s disease and show a convergent signature with psychopathology across multiple cell types.
The brain dynamically transforms cognitive information. Here the authors build task-performing, functioning neural network models of sensorimotor transformations constrained by human brain data without the use of typical deep learning techniques.
To expand its GPT capabilities, OpenAI released its long-anticipated o1 model, in addition to a smaller, cheaper o1-mini version. Previously known as Strawberry, the company says these releases can “reason through complex tasks and solve harder problems than previous models in science, coding, and math.”
Although it’s still a preview, OpenAI states this is the first of this series in ChatGPT and on its API, with more to come.
The company says these models have been training to “spend more time thinking through problems before they respond, much like a person would. Through training, they learn to refine their thinking process, try different strategies, and recognize their mistakes.”
I find it weird that black holes would be moving throughout the galaxy because most are stationary.
A fluffy cluster of stars spilling across the sky may have a secret hidden in its heart: a swarm of over 100 stellar-mass black holes.
The star cluster in question is called Palomar 5. It’s a stellar stream that stretches out across 30,000 light-years, and is located around 80,000 light-years away.
Such globular clusters are often considered ‘fossils’ of the early Universe. They’re very dense and spherical, typically containing roughly 100,000 to 1 million very old stars; some, like NGC 6397, are nearly as old as the Universe itself.
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