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Limited color channels in fluorescence microscopy have long constrained spatial analysis in biological specimens. Here, we introduce cycle Hybridization Chain Reaction (HCR), a method that integrates multicycle DNA barcoding with HCR to overcome this limitation. cycleHCR enables highly multiplexed imaging of RNA and proteins using a unified barcode system. Whole-embryo transcriptomics imaging achieved precise three-dimensional gene expression and cell fate mapping across a specimen depth of ~310 μm. When combined with expansion microscopy, cycleHCR revealed an intricate network of 10 subcellular structures in mouse embryonic fibroblasts. In mouse hippocampal slices, multiplex RNA and protein imaging uncovered complex gene expression gradients and cell-type-specific nuclear structural variations.

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New research on the inner ear morphology of Neanderthals and their ancestors challenges the widely accepted theory that Neanderthals originated after an evolutionary event that implied the loss of part of their genetic diversity. The findings, based on fossil samples from Atapuerca (Spain) and Krapina (Croatia), as well as from various European and Western Asian sites have been published in Nature Communications.

Neanderthals emerged about 250,000 years ago from European populations—referred to as “pre-Neanderthals”—that inhabited the Eurasian continent between 500,000 and 250,000 years ago. It was long believed that no significant changes occurred throughout the evolution of Neanderthals, yet recent paleogenetic research based on DNA samples extracted from fossils revealed the existence of a drastic genetic diversity loss event between early Neanderthals (or ancient Neanderthals) and later ones (also referred to as “classic” Neanderthals).

Technically known as a “bottleneck,” this genetic loss is frequently the consequence of a reduction in the number of individuals in a population. Paleogenetic data indicate that the decline in took place approximately 110,000 years ago.

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A new study by researchers at the Max Planck Institute for Evolutionary Biology (MPI-EB) sheds fresh light on one of the most debated concepts in biology: evolvability. The work provides the first experimental evidence showing how natural selection can shape genetic systems to enhance future capacity for evolution, challenging traditional perspectives on evolutionary processes.

The research is published in the journal Science. A related Perspective article also appears in Science.

The ability of organisms to generate adaptive genetic variation is crucial for evolutionary success, particularly in changing environments. The MPI-EB study investigates whether operates not merely as a “blind” process driven by but could actively favor mechanisms that channel mutations toward adaptive outcomes.

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And understanding these waves a little better could help scientists better predict when and where they’ll happen, as well as how strong they’ll be. That could be vital to the safety of satellites orbiting our planet, which are vulnerable to solar storms and other sudden bursts of radiation from deep space.

“These high-energy electrons are known as ‘killer electrons’ because they have damaged several satellites, costing hundreds of millions of dollars,” wrote Horne. “Chorus waves are now included in forecasting models that are designed to protect these satellites.”

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As the fundamental flaw of today’s quantum computers, improving qubit stability remains the focus of much research in this field. One such stability attempt involves so-called topological quantum computing with the use of anyons, which are two-dimensional quasiparticles. Such an approach has been claimed by Microsoft in a recent paper in Nature. This comes a few years after an earlier claim by Microsoft for much the same feat, which was found to be based on faulty science and hence retracted.

The claimed creation of anyons here involves Majorana fermions, which differ from the much more typical Dirac fermions. These Majorana fermions are bound with other such fermions as a Majorana zero mode (MZM), forming anyons that are intertwined (braided) to form what are in effect logic gates. In the Nature paper the Microsoft researchers demonstrate a superconducting indium-arsenide (InAs) nanowire-based device featuring a read-out circuit (quantum dot interferometer) with the capacitance of one of the quantum dots said to vary in a way that suggests that the nanowire device-under-test demonstrates the presence of MZMs at either end of the wire.

Microsoft has a dedicated website to their quantum computing efforts, though it remains essential to stress that this is not a confirmation until their research is replicated by independent researchers. If confirmed, MZMs could provide a way to create more reliable quantum computing circuitry that does not have to lean so heavily on error correction to get any usable output. Other, competing efforts here include such things as hybrid mechanical qubits and antimony-based qubits that should be more stable owing to their eight spin configurations.

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Scientists have discovered a potentially greener way to produce a crucial industrial chemical used to make many everyday products, from plastics and textiles to antifreeze and disinfectants, according to a study published in Science and co-authored by Tulane University chemical engineer Matthew Montemore.

The breakthrough could significantly reduce from the manufacture of ethylene oxide, which has an estimated $40 billion global market. The current production process requires chlorine, which is toxic and emits millions of tons of carbon dioxide into the atmosphere annually.

The research team, led by Montemore, as well as Tufts University chemistry professor Charles Sykes and University of California Santa Barbara (UCSB) chemical engineering professor Phillip Christopher, found that adding small amounts of nickel atoms to silver catalysts can maintain while eliminating the need for chlorine in the process.

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We knew this day would come. For years now, scientists have been trying to make Westworld a reality with their advances in android robots.

From lab-grown muscle tissue to robots with bones, ligaments and tendons, android robots have rapidly been getting more and more lifelike.

Now, a company named Clone Robotics has created something they are calling the Protoclone – a “faceless, anatomically accurate, synthetic human with over 200 degrees of freedom, over 1,000 Myofibers, and over 200 sensors.” Sound terrifying? Just wait until you see video of it twitching and spasming its way into action.

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In a major leap forward for energy storage technology, a team of researchers from South Korea has developed a groundbreaking method that could revolutionize the manufacturing of sodium-ion batteries. This innovation not only promises to enhance battery efficiency but could also reshape how we think about energy storage and its future applications in various industries.

At the Korea Electrotechnology Research Institute (KERI), a team led by Dr. Kim and Dr. Park has achieved a breakthrough in the production of hard carbon anodes for sodium-ion batteries. By using a method that involves microwave induction heating, they are now able to prepare these anodes in just 30 seconds —a dramatic improvement over conventional methods. This quick processing technique could significantly reduce manufacturing times and costs, potentially making sodium-ion batteries a more viable option for widespread use.

The research team’s approach has already gained considerable attention in the scientific community, as it marks a significant step toward the commercialization of sodium-ion batteries, which are seen as a safer, more sustainable alternative to lithium-ion batteries.

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A recent study published in Science by a Belgian research team investigates how genetic switches that regulate gene activity define brain cell types across different species.

A species is a group of living organisms that share a set of common characteristics and are able to breed and produce fertile offspring. The concept of a species is important in biology as it is used to classify and organize the diversity of life. There are different ways to define a species, but the most widely accepted one is the biological species concept, which defines a species as a group of organisms that can interbreed and produce viable offspring in nature. This definition is widely used in evolutionary biology and ecology to identify and classify living organisms.

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