Alopecia is an autoimmune disorder that causes non-scarring hair loss on the scalp and body that is experienced by almost 2% of the global population at some point in their lifetime.
A team of researchers from Australia, Singapore, and China discovered that activated hair follicle stem cells (HFSCs), crucial for hair regrowth and repair, require a powerful protector protein called MCL-1 to function successfully. Without MCL-1, these cells undergo stress and eventually die, leading to hair loss, as reported in a Nature Communications study.
Hair follicles are small tunnel-like structures in the skin where hair grows. These follicles repeatedly cycle through three distinct phases: anagen, the active growth phase; catagen, a transitional phase marked by slowed growth and follicle shrinkage; and telogen, a resting phase where growth ceases and shedding occurs, after which the cycle begins afresh, driven by HFSCs.