This animated map shows the last billion years of Earth’s tectonic plate movement in just 40 seconds, showing how continents formed.
Manufactured on tsmc’s 180 nm process.
Libre-SOC developers sent the first test ASIC to TSMC’s manufacturing facilities.
What is AMD Infinity Cache?
Posted in computing, entertainment
Infinity Cache is one of the headline features found in AMD’s RDNA 2 – the GPU architecture behind the next generation of gaming graphics, including the PS5, the Xbox Series X and, of course, AMD’s own Radeon RX 6000 graphics cards. But, what is Infinity Cache?
Read on to learn more about Infinity Cache, how it works and where you can find it.
Infinity Cache is an all-new cache level AMD says will improve the efficiency and performance of its RDNA 2 architecture during 4K and 1440p gaming.
Circa 2010
In this review, we consider the evidence that a reduction in neurogenesis underlies aging-related cognitive deficits, and impairments in disorders such as Alzheimer’s disease (AD). The molecular and cellular alterations associated with impaired neurogenesis in the aging brain are discussed. Dysfunction of presenilin-1, misprocessing of amyloid precursor protein and toxic effects of hyperphosphorylated tau and β-amyloid likely contribute to impaired neurogenesis in AD. Since factors such as exercise, enrichment and dietary energy restriction enhance neurogenesis, and protect against age-related cognitive decline and AD, knowledge of the underlying neurogenic signaling pathways could lead to novel therapeutic strategies for preserving brain function. In addition, manipulation of endogenous neural stem cells and stem cell transplantation, as stand-alone or adjunct treatments, seem promising.
There is a progressive decline in the regenerative capacity of most organs with increasing age, resulting in functional decline and poor repair from injury and disease. Once thought to exist only in high turnover tissues, such as the intestinal lining or bone marrow, it now appears that most tissues harbor stem cells that contribute to tissue integrity throughout life. In many cases, stem cell numbers decrease with age, suggesting stem cell aging may be of fundamental importance to the biology of aging (for review, see Ref. [1]). Therefore, understanding the regulation of stem cell maintenance and/or activation is of considerable relevance to understanding the age-related decline in maintaining tissue integrity, function, and regenerative response.
The adult brain contains neural stem cells (NSCs) that self-renew, proliferate and give rise to neural progenitor cells (NPC) that exhibit partial lineage-commitment. Following several cycles of proliferation, NPC differentiate into new neurons and glia. NSCs are increasingly acknowledged to be of functional significance and harbor potential for repair of the diseased or injured brain. The dramatic decline in neurogenesis with age is thought to underlie impairments in learning and memory, at least in part. Aging is also the greatest risk factor for Alzheimer’s disease (AD), a neurodegenerative disease characterized by progressive loss of memory and cognitive decline. Alterations in neurogenesis have been described extensively in animal models of AD, and key proteins involved in AD pathogenesis are shown to regulate neurogenesis.
Breast cancer is the leading cause of cancer death in women around the world, responsible for 1700 deaths every day. Although the vast majority of breast cancers are treatable, the most aggressive subtype—triple negative breast cancer (TNBC) – has a high recurrence rate, a high potential for metastasis and shows resistance to conventional treatments, leading to very poor prognosis and survival outcomes. A team of researchers at the Research Institute of the McGill University Health Center (RI-MUHC) conducted a preclinical study and discovered a novel targeted combination therapy that efficiently reduced tumor growth in metastatic breast cancer. Published in Nature Communications, their findings could lead to the development of a novel first line targeted therapy for the treatment of TNBC, with the prospect of rapidly transitioning to clinical trials in humans.
“There is no targeted therapy for TNBC. Chemotherapy treatment can even enrich these tumors in cancer stem cells and be detrimental to the patient, as we have shown in a previous study,” says Dr. Jean-Jacques Lebrun, senior scientist in the Cancer Research Program at the RI-MUHC and principal investigator of the study. “Filling that huge medical gap was our motivation in conducting this study.”
While most breast cancers have one of three main receptors that are like entrance gates for treatments—estrogen, progesterone and a protein called human epidermal growth factor (HER2) – TNBC has none, thus the name triple negative breast cancer. Using state-of-the-art technologies such as gene editing and genome-wide molecular approaches, the team identified two pathways which could be targeted in a therapeutic strategy.
These flaws in AI training give the technology a bad name, and so do regular media reports suggesting that intelligent machines are poised to decimate the human workforce. These themes, for many people, have obscured AI’s genuine usefulness in data analysis and conversational platforms. And while computer vision does indeed have its flaws, it is more than just a reflection of societal biases: it is potentially an essential tool for both society and business.
Computer vision, or CV, gives machines the power of visual recognition in a way that emulates human sight. Whether a machine is detecting dangers on the road or, more controversially, recognising faces in a crowd, the ultimate aim is to make decisions based on image interpretation.
The tech is an advanced form of pattern recognition, made through statistical comparison of data sets. This means that while machines can “see”, they have no real understanding of what they are looking at. They can distinguish one object from another, true, but can’t explain what this difference means.
These themes, for many people, have obscured AI’s genuine usefulness in data analysis and conversational platforms. And while computer vision does indeed have its flaws, it is more than just a reflection of societal biases: it is potentially an essential tool for both society and business.
Computer vision, or CV, gives machines the power of visual recognition in a way that emulates human sight. Whether a machine is detecting dangers on the road or, more controversially, recognising faces in a crowd, the ultimate aim is to make decisions based on image interpretation.
The tech is an advanced form of pattern recognition, made through statistical comparison of data sets. This means that while machines can “see”, they have no real understanding of what they are looking at. They can distinguish one object from another, true, but can’t explain what this difference means.
A stunning new image from the South African MeerKAT telescope captures powerful radio emissions woven through space.
The radio emissions emanate from an enormous rotating black hole that lies at the center of an elliptical galaxy known as IC 4296. Energy released by matter falling into the black hole generates two radio jets of high energy gas on opposite sides of the galaxy — creating what is also known as a double-lobed radio galaxy.
“Once the virus is recognised, the CRISPR enzyme is activated and chops up the virus,” she said.
Paris (AFP)
Scientists have used CRISPR gene-editing technology to successfully block the transmission of the SARS-CoV-2 virus in infected human cells, according to research released Tuesday that could pave the way for Covid-19 treatments.
Writing in the journal Nature Communications, researchers in Australia said the tool was effective against viral transmissions in lab tests, adding that they hoped to begin animal trials soon.