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What’s exciting about our findings is that we have identified a molecular pathway that is activated in normal acute wounds in humans, and altered in diabetic wounds in mice,” said Ghaidaa Kashgari, Ph.D., a postdoctoral researcher in the UCI School of Medicine Department of Medicine. “This finding strongly indicates clinical relevance and may improve our understanding of wound healing biology and could lead to new therapies.

A University of California, Irvine-led study identifies a new molecular pathway that promotes the healing of wounds in the skin. Titled “GRHL3 activates FSCN1 to relax cell-cell adhesions between migrating keratinocytes during wound reepithelialization,” the study was published today in JCI Insight.

The molecular pathway identified is controlled by an evolutionary conserved gene called a Grainyhead like 3 (GRHL3), which is a gene required for mammalian development. Without this gene, several abnormalities may occur, including spina bifida, defective epidermal barrier, defective eyelid closure and soft-tissue syndactyly, a condition in which children are born with fused or webbed fingers.

The study reveals how during wound healing, GRHL3 works to activate a protein coding gene called Fascin Actin-Bundling Protein 1 (Fscn1) to loosen the adhesion between wounded skin cells so they can migrate efficiently to close the wound. Researchers also found that alterations in this process may result in chronic, non-healing wounds, such as diabetic ulcers that affect millions of patients every year.

Continue reading “Research uncovers new mechanism that promotes wound healing in skin” | >

Many human diseases can differ between males and females in their prevalence, manifestation, severity or age of onset. Examples include Lupus, where more than 80% of patients are females; Alzheimer’s disease, where females have higher incidence and tend to suffer quicker cognitive decline; and COVID-19 infections that are frequently more severe in males.

These sex differences may have a that is attributable to the sex . The X chromosome—one of the two sex chromosomes—is known to play an important role in human development and disease. New research led by Penn State College of Medicine reveals for the first time that sex-biased diseases can be attributable to that escape X chromosome inactivation (XCI), a process that ensures that females do not overexpress genes on their X-chromosomes.

The team developed a that can identify these XCI escape genes, and it may also help in determining whether a female will develop a sex-biased disease and if the disease will become progressively worse over time. The tool may even be useful in understanding the in immune responses to COVID-19, as the disease is thought to produce more severe symptoms and higher mortality in men than in women.

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In this video Dr. Katcher reveals his thought on the future of aging if E5 is fulfils on its promise.

Dr Katcher’s book is on Amazon.
The Illusion of Knowledge: The paradigm shift in aging research that shows the way to human rejuvenation.
https://amzn.to/3jJ5deD

Dr Harold Katcher is one of the discovers of the human breast cancer gene BRCA1, and has thousands of citations in the scientific literature with publications ranging from protein structure to bacteriology, bioinformatics and biochemistry. He was the Academic Director for Natural Sciences of the University of Maryland Global Campus and is now the Chief Scientific Officer at Yuvan Research Inc, a company working on the development of rejuvenation treatments.

Dr Katcher’s new book, the Illusion of Knowledge, the paradigm shift in aging research that shows the way to human rejuvenation will be launched on 4th September 2021 and is already available in electronic form. The book launch will take place at The Book Passage in the Ferry Building in San Francisco at 3:00 pm Pacific Time.

Continue reading “The Future of Aging | Dr. Harold Katcher Interview Series 2 — Ep5” | >

Japan says it has scrambled fighter aircraft to intercept Chinese military drones and accompanying surveillance aircraft on three consecutive days this week as its defense forces took part in a series of readiness exercises with regional allies.

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Summary: A new study on aging reveals a surprising discovery about the connection between protein shape and mitochondrial health.

Source: Buck Institute.

Every cell in the body goes through thousands of chemical reactions each day, and each reaction involves tiny protein molecules folded into precise shapes to perform their functions. Misfolded proteins underlie some of the most common and devastating diseases of aging, like Alzheimer’s and Parkinson’s. A major focus of aging research is discovering ways to maintain protein shape and prevent misfolded proteins from wreaking havoc on cellular function.

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Circa 2019

LONDON — A laboratory in Switzerland has found a way of using a laser to change and regulate the polarization, wavelength and intensity of light in “excitons” in 2D materials, creating the potential for a new generation of transistors with less energy loss and heat dissipation, opening up the potential for low-power quantum computing.

Excitons are created when an electron absorbs light and moves into a higher energy level, or “energy band” as it is called in solid quantum physics. This excited electron leaves behind an “electron hole” in its previous energy band. And because the electron has a negative charge and the hole a positive charge, the two are bound together by an electrostatic force called a Coulomb force. It’s this electron-electron hole pair that is referred to as an exciton.

Scientists from EPFL’s Laboratory of Nanoscale Electronics and Structures (LANES) had already developed a method to control exciton flows at room temperature last year. In the latest development, they have discovered new properties of these quasiparticles that can lead to more energy-efficient electronic devices and have found a way to control some of the properties and change the polarization of the light they generate. The scientists’ discovery forms part of a relatively new field of research called valleytronics and has just been published in Nature Photonics.

Continue reading “‘Excitons’ Show Potential for Low-Power Quantum Computing” | >

Circa 2012

Quantum ground-state problems are computationally hard problems for general many-body Hamiltonians; there is no classical or quantum algorithm known to be able to solve them efficiently. Nevertheless, if a trial wavefunction approximating the ground state is available, as often happens for many problems in physics and chemistry, a quantum computer could employ this trial wavefunction to project the ground state by means of the phase estimation algorithm (PEA). We performed an experimental realization of this idea by implementing a variational-wavefunction approach to solve the ground-state problem of the Heisenberg spin model with an NMR quantum simulator. Our iterative phase estimation procedure yields a high accuracy for the eigenenergies (to the 10–5 decimal digit).

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New photo-oxygenation catalyst targets amyloid structure, recruits brain immune system cells.

A small, light-activated molecule recently tested in mice represents a new approach to eliminating clumps of amyloid protein found in the brains of Alzheimer’s disease patients. If perfected in humans, the technique could be used as an alternative approach to immunotherapy and used to treat other diseases caused by similar amyloids.

Researchers injected the molecule directly into the brains of live mice with Alzheimer’s disease and then used a specialized probe to shine light into their brains for 30 minutes each day for one week. Chemical analysis of the mouse brain tissue showed that the treatment significantly reduced amyloid protein. Results from additional experiments using human brain samples donated by Alzheimer’s disease patients supported the possibility of future use in humans.

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I wish I had some sort of different response to give than this, but this summary is totally clear-eyed about the coming Semantic Apocalypse.

Artistic corpocracy

It’s actually even worse (in a way aptly not noticed by the Google employee). Because as we discussed, in the future advanced versions of this sort of AI will be solely owned and developed by Big Tech due the scaling laws around how they’re trained and run. The immediate licensing of GPT-3 by Microsoft was an augury of this. Indeed, the rights to interact with these AIs will be some of the most valuable licenses on the planet in the next decade. Consumers, even academic AI researchers, will communicate with company-owned trillion-parameter AIs solely via oracles, getting nowhere near the source code. The future of this technology belongs to huge corporations with major resources. So it’s not really that “AI is automating art”—no, corporations are automating art. And writing. And translation. And illustration. And music. And the thousand other human forms of creativity that give life meaning. They are now the province of Big Tech.

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