Lifeboat Foundation

“In our current study we were able to uncover important limitations for the use of metformin as longevity medicine,” says Dr. Ermolaeva. In contrast to the positive longevity effects in young organisms that received metformin, lifespan is shortened through metformin intake at an older age. “Previous studies that provided evidence of an extended longevity by metformin usually examined animals treated with metformin from young adult or middle age until the end of life. In contrast, we have looked at treatment windows covering the entire life span, or restricted to early life or to late life”. The study also utilized a human cell culture model of replicative aging to assess human responses to metformin at a cellular level and compare them to organismal responses of the worms.

**Metformin longevity benefits are reversed with age**

The research team led by Dr. Ermolaeva found that the very same metformin treatment that prolonged life when C. elegans worms were treated at young age, was highly toxic when animals of old age were treated. Up to 80% of the population treated at old age were killed by metformin within the first 24 hours of treatment. Consistently, human primary cells demonstrated a progressive decrease in metformin tolerance as they approached replicative senescence. The researchers were able to link this detrimental phenotype to the reduced ability of old cells and old nematodes to adapt to metabolic stressors like metformin. Under these circumstances, the exact same dose of the drug that increased longevity of young-treated organisms by triggering adaptive stress responses was harmful in animals treated at old age, which were unable to activate such protective signals.

Continue reading “Age is decisive for positive or negative effects of the diabetes drug metformin” »

“I mean, I suspect we could have an army of 120,000, of which 30,000 might be robots, who knows?” Carter said, although he stressed he was not setting any particular target in terms of future numbers.

Investment in robot warfare was to be at the heart of the planned integrated five-year defence review, whose future was thrown into doubt after the chancellor, Rishi Sunak, postponed the cross-government spending review to which it had been linked last month.

Carter said negotiations with Downing Street and the Treasury about salvaging the multi-year defence funding settlement were “going on in a very constructive way” – as he lobbied in public for a long-term financial deal.

It will allow for near-instantaneous virtual interactions, allowing people to send a hug to a loved one or shake hands with a colleague online. Its increased capacity and speed will revolutionise virtual reality and allow for wholesale ‘teleportation of senses’, researchers claim.

Potential applications include doctors monitoring patients remotely, embracing and holding hands with a loved one who may be thousands of miles away, and having virtual meetings with no lag…

Continue reading “UK’s first 6G innovation centre launches at University of Surrey” »

New device puts music in your head — no headphones required…

LONDON (AP) — Imagine a world where you move around in your own personal sound bubble. You listen to your favorite tunes, play loud computer games, watch a movie or get navigation directions in your car — all without disturbing those around you.

That’s the possibility presented by “sound beaming,” a new futuristic audio technology from Noveto Systems, an Israeli company. On Friday it will debut a desktop device that beams sound directly to a listener without the need for headphones.

Continue reading “New device puts music in your head — no headphones required” »

Using algorithms derived from neuroscience, AI research company Numenta has achieved a dramatic performance improvement in deep learning networks, without any loss in accuracy. Their breakthrough is also vastly more energy efficient.

Researchers discover an unexpected new class of superconducting material.

Superconducting materials are traditionally classed into two types: s-wave and d-wave. A third type, p-wave, has long been predicted. Now, however, researchers in the US, Germany and Japan say they may have discovered a fourth, unexpected type of superconductor: g-wave. The result, obtained thanks to high-precision resonant ultrasound spectroscopy measurements on strontium ruthenate, could shed fresh light on the Cooper pairing mechanisms in so-called unconventional superconductors.

Forget glue, screws, heat or other traditional bonding methods. A Cornell University-led collaboration has developed a 3D printing technique that creates cellular metallic materials by smashing together powder particles at supersonic speed.

This form of technology, known as “cold spray,” results in mechanically robust, porous structures that are 40% stronger than similar materials made with conventional manufacturing processes. The structures’ small size and porosity make them particularly well-suited for building biomedical components, like replacement joints.

The team’s paper, “Solid-State Additive Manufacturing of Porous Ti-6Al-4V by Supersonic Impact,” published Nov. 9 in Applied Materials Today.

I guess we need to thank our neanderthal forebearers. 😃

A new study shows how interbreeding of modern humans and Neanderthals boosted our genomes.

In a piece for The Atlantic, Ezekiel Emanuel wrote in 2014 that 75 is a “pretty good age to aim to stop.”